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GO:0008385 IkappaB kinase complex

Term Information

ID GO:0008385
Name IkappaB kinase complex
Ontology Cellular Component
Definition A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
PMID:12055104 PMID:20300203
GONUTS GO:0008385 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact trimeric IKK complex
exact heterotrimeric IKK complex
exact IKK complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008385:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008385. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008385 based on the entire annotation set Co-occurrence statistics for GO:0008385 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-11 Added RELATION is a GO:1902554 (serine/threonine protein kinase complex)
2013-12-11 Deleted RELATION is a GO:1990234 (transferase complex)
2013-11-28 Added RELATION is a GO:1990234 (transferase complex)
2013-11-28 Deleted RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Added RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Deleted RELATION is a GO:0043234 (protein complex)
2012-01-12 Added SYNONYM trimeric IKK complex
2012-01-12 Added SYNONYM heterotrimeric IKK complex
2012-01-11 Deleted DEFINITION A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2012-01-11 Added DEFINITION A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2008-05-13 Added DEFINITION A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2008-05-12 Deleted DEFINITION A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044445 (cytosolic part)
2007-08-09 Added SYNONYM IKK complex
2007-08-09 Deleted SYNONYM IKK complex
2005-05-20 Added SYNONYM IKK complex
2002-11-27 Updated DEFINITION A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2002-07-09 Updated TERM IkappaB kinase complex
2002-05-24 Updated TERM IkB kinase complex
2002-02-06 Updated TERM IkB kinase
2001-08-06 Added DEFINITION A protein serine/threonine kinase that phosphoryates IkB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2001-04-03 Updated TERM IkB kinase
2001-03-30 Added TERM IkB kinase

Term

Timestamp Action Category Detail
2002-07-09 Updated TERM IkappaB kinase complex
2002-05-24 Updated TERM IkB kinase complex
2002-02-06 Updated TERM IkB kinase
2001-04-03 Updated TERM IkB kinase
2001-03-30 Added TERM IkB kinase

Definition/synonyms

Timestamp Action Category Detail
2012-01-12 Added SYNONYM trimeric IKK complex
2012-01-12 Added SYNONYM heterotrimeric IKK complex
2012-01-11 Deleted DEFINITION A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2012-01-11 Added DEFINITION A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2008-05-13 Added DEFINITION A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2008-05-12 Deleted DEFINITION A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2007-08-09 Added SYNONYM IKK complex
2007-08-09 Deleted SYNONYM IKK complex
2005-05-20 Added SYNONYM IKK complex
2002-11-27 Updated DEFINITION A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2001-08-06 Added DEFINITION A protein serine/threonine kinase that phosphoryates IkB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.

Relationships

Timestamp Action Category Detail
2013-12-11 Added RELATION is a GO:1902554 (serine/threonine protein kinase complex)
2013-12-11 Deleted RELATION is a GO:1990234 (transferase complex)
2013-11-28 Added RELATION is a GO:1990234 (transferase complex)
2013-11-28 Deleted RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Added RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Deleted RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044445 (cytosolic part)
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