spacer

GO:0008384 IkappaB kinase activity

Term Information

ID GO:0008384
Name IkappaB kinase activity
Ontology Molecular Function
Definition Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.
Comment Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB.
GONUTS GO:0008384 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact inhibitor of NFkappaB kinase activity
exact inhibitor of NF-kappaB kinase activity
exact ikappaB kinase activity
related TBK1
related CHUK
related STK12
related IKK-2
related IKK-1
related IKK
related IKBKB
related IKBKA
exact ATP:IkappaB protein phosphotransferase activity
narrow TANK-binding kinase 1 activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.7.11.10
InterPro IPR022007
MetaCyc 2.7.11.10-RXN

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008384:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008384. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008384 based on the entire annotation set Co-occurrence statistics for GO:0008384 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-11 Added RELATION part of GO:0007252 (I-kappaB phosphorylation)
2009-05-21 Added XREF MetaCyc:2.7.11.10-RXN
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.
2008-04-01 Updated RELATION is a GO:0004674 (protein serine/threonine kinase activity)
2007-11-08 Added SYNONYM ATP:IkappaB protein phosphotransferase activity
2007-11-08 Added SYNONYM CHUK
2007-11-08 Added SYNONYM IKBKA
2007-11-08 Added SYNONYM IKBKB
2007-11-08 Added SYNONYM IKK
2007-11-08 Added SYNONYM IKK-1
2007-11-08 Added SYNONYM IKK-2
2007-11-08 Added SYNONYM STK12
2007-11-08 Added SYNONYM TANK-binding kinase 1 activity
2007-11-08 Added SYNONYM TBK1
2007-11-08 Added SYNONYM ikappaB kinase activity
2007-11-08 Added SYNONYM inhibitor of NF-kappaB kinase activity
2007-11-08 Added SYNONYM inhibitor of NFkappaB kinase activity
2007-10-25 Updated DEFINITION Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.
2007-09-26 Added XREF EC:2.7.11.10
2007-09-26 Deleted XREF EC:2.7.1.-
2003-08-06 Updated DEFINITION Catalysis of the phosphorylation of IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2003-03-19 Updated TERM IkappaB kinase activity
2002-11-27 Updated DEFINITION A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2002-07-09 Updated TERM IkappaB kinase
2002-02-06 Updated TERM IkB kinase
2001-08-06 Added DEFINITION A protein serine/threonine kinase that phosphoryates IkB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2001-04-03 Updated TERM IkB kinase
2001-03-30 Added XREF EC:2.7.1.-
2001-03-30 Added TERM IkB kinase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM IkappaB kinase activity
2002-07-09 Updated TERM IkappaB kinase
2002-02-06 Updated TERM IkB kinase
2001-04-03 Updated TERM IkB kinase
2001-03-30 Added TERM IkB kinase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.
2007-11-08 Added SYNONYM ATP:IkappaB protein phosphotransferase activity
2007-11-08 Added SYNONYM CHUK
2007-11-08 Added SYNONYM IKBKA
2007-11-08 Added SYNONYM IKBKB
2007-11-08 Added SYNONYM IKK
2007-11-08 Added SYNONYM IKK-1
2007-11-08 Added SYNONYM IKK-2
2007-11-08 Added SYNONYM STK12
2007-11-08 Added SYNONYM TANK-binding kinase 1 activity
2007-11-08 Added SYNONYM TBK1
2007-11-08 Added SYNONYM ikappaB kinase activity
2007-11-08 Added SYNONYM inhibitor of NF-kappaB kinase activity
2007-11-08 Added SYNONYM inhibitor of NFkappaB kinase activity
2007-10-25 Updated DEFINITION Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.
2003-08-06 Updated DEFINITION Catalysis of the phosphorylation of IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2002-11-27 Updated DEFINITION A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.
2001-08-06 Added DEFINITION A protein serine/threonine kinase that phosphoryates IkB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role.

Relationships

Timestamp Action Category Detail
2012-01-11 Added RELATION part of GO:0007252 (I-kappaB phosphorylation)
2008-04-01 Updated RELATION is a GO:0004674 (protein serine/threonine kinase activity)

Cross-references

Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:2.7.11.10-RXN
2007-09-26 Added XREF EC:2.7.11.10
2007-09-26 Deleted XREF EC:2.7.1.-
2001-03-30 Added XREF EC:2.7.1.-
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
16ms