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GO:0008373 sialyltransferase activity

Term Information

ID GO:0008373
Name sialyltransferase activity
Ontology Molecular Function
Definition Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
GONUTS GO:0008373 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.4.99.-
InterPro IPR001675
InterPro IPR012163

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008373:
Relationship To GO:0008373 Child Term Child Term Name
Is a GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
Is a GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity
Is a GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
Is a GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
Is a GO:0047287 lactosylceramide alpha-2,6-N-sialyltransferase activity
Is a GO:0047288 monosialoganglioside sialyltransferase activity
Is a GO:0047289 galactosyldiacylglycerol alpha-2,3-sialyltransferase activity
Is a GO:0047290 (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
Is a GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity
Is a GO:0004513 neolactotetraosylceramide alpha-2,3-sialyltransferase activity
Is a GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity
Is a GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity

Protein Annotation

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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008373. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008373 based on the entire annotation set Co-occurrence statistics for GO:0008373 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-09-22 Deleted DEFINITION Catalysis of the transfer of sialic acid to the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
2013-09-22 Added DEFINITION Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
2013-09-22 Added RELATION part of GO:0097503 (sialylation)
2011-10-10 Deleted DEFINITION Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors.
2011-10-10 Added DEFINITION Catalysis of the transfer of sialic acid to the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
2011-10-10 Deleted XREF MetaCyc:2.4.99.10-RXN
2009-05-21 Added XREF MetaCyc:2.4.99.10-RXN
2008-05-13 Added DEFINITION Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors.
2008-05-12 Deleted DEFINITION Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors.
2008-04-01 Updated RELATION is a GO:0016757 (transferase activity, transferring glycosyl groups)
2003-03-19 Updated TERM sialyltransferase activity
2002-11-27 Added DEFINITION Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors.
2002-02-06 Updated TERM sialyltransferase
2001-04-03 Updated TERM sialyltransferase
2001-03-30 Added XREF EC:2.4.99.-
2001-03-30 Added TERM sialyltransferase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM sialyltransferase activity
2002-02-06 Updated TERM sialyltransferase
2001-04-03 Updated TERM sialyltransferase
2001-03-30 Added TERM sialyltransferase

Definition/synonyms

Timestamp Action Category Detail
2013-09-22 Deleted DEFINITION Catalysis of the transfer of sialic acid to the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
2013-09-22 Added DEFINITION Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
2011-10-10 Deleted DEFINITION Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors.
2011-10-10 Added DEFINITION Catalysis of the transfer of sialic acid to the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
2008-05-13 Added DEFINITION Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors.
2008-05-12 Deleted DEFINITION Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors.
2002-11-27 Added DEFINITION Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors.

Relationships

Timestamp Action Category Detail
2013-09-22 Added RELATION part of GO:0097503 (sialylation)
2008-04-01 Updated RELATION is a GO:0016757 (transferase activity, transferring glycosyl groups)

Cross-references

Timestamp Action Category Detail
2011-10-10 Deleted XREF MetaCyc:2.4.99.10-RXN
2009-05-21 Added XREF MetaCyc:2.4.99.10-RXN
2001-03-30 Added XREF EC:2.4.99.-
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