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GO:0004707 MAP kinase activity

Term Information

ID GO:0004707
Name MAP kinase activity
Ontology Molecular Function
Definition Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
Secondary IDs GO:0008338 GO:0008339 GO:0016908
GONUTS GO:0004707 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related STK26
narrow extracellular signal-regulated kinase activity
exact mitogen activated kinase activity
exact mitogen-activated protein kinase activity
narrow myelin basic protein kinase activity
related p38-2
related p38delta
narrow p42 mitogen-activated protein kinase activity
related p42mapk
related p44mpk
related pp42
related pp44mapk
narrow Mpk2
narrow MAP kinase 1 activity
exact ERK1
related ERK2
narrow MAP kinase 2 activity
narrow SAPK2
narrow p38
narrow MP kinase activity
exact ATP:protein phosphotransferase (MAPKK-activated) activity
related Dp38
related ERK
related LeMPK3
narrow MAP-2 kinase activity
related MAPK
narrow MBP kinase I activity
narrow MBP kinase II activity
related PMK-1
related PMK-2
related PMK-3

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000015 GO:0000165 MAPK cascade only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Cross-references

Database ID
EC 2.7.11.24
InterPro IPR003527
InterPro IPR008349
InterPro IPR008350
InterPro IPR008351
InterPro IPR008352
KEGG R00162
MetaCyc 2.7.11.24-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004707:
Relationship To GO:0004707 Child Term Child Term Name
Is a GO:0016909 SAP kinase activity
Regulates GO:0043405 regulation of MAP kinase activity
Positively regulates GO:0043406 positive regulation of MAP kinase activity
Negatively regulates GO:0043407 negative regulation of MAP kinase activity
Is a GO:0038067 MAP kinase activity involved in cell wall organization or biogenesis
Is a GO:0038071 MAP kinase activity involved in conjugation with cellular fusion
Is a GO:0038075 MAP kinase activity involved in innate immune response
Is a GO:0038079 MAP kinase activity involved in osmosensory signaling pathway

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004707. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004707 based on the entire annotation set Co-occurrence statistics for GO:0004707 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-29 Added RELATION part of GO:0000165 (MAPK cascade)
2011-05-03 Deleted XREF EC:2.7.11.-
2010-10-13 Added SYNONYM ERK2
2010-10-13 Added SYNONYM MAP kinase 2 activity
2010-10-13 Added SYNONYM SAPK2
2010-10-13 Added SYNONYM p38
2010-10-13 Added SYNONYM MP kinase activity
2010-10-13 Added SYNONYM Mpk2
2010-10-13 Added SYNONYM MAP kinase 1 activity
2010-10-13 Added SYNONYM ERK1
2010-10-13 Added SECONDARY GO:0016908 (MAP kinase 2 activity)
2010-10-13 Added SECONDARY GO:0008339 (MP kinase activity)
2010-10-13 Added SECONDARY GO:0008338 (MAP kinase 1 activity)
2010-10-13 Added XREF EC:2.7.11.-
2010-09-15 Added DEFINITION Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2010-09-15 Deleted DEFINITION Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2010-09-15 Added XREF KEGG:R00162
2009-05-21 Added XREF MetaCyc:2.7.11.24-RXN
2008-06-03 Deleted SYNONYM microtubule-associated protein 2 kinase activity
2008-06-03 Deleted SYNONYM microtubule-associated protein kinase activity
2008-05-13 Added DEFINITION Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2008-05-12 Deleted DEFINITION Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2008-04-01 Updated RELATION is a GO:0004702 (receptor signaling protein serine/threonine kinase activity)
2007-11-08 Added SYNONYM ATP:protein phosphotransferase (MAPKK-activated) activity
2007-11-08 Added SYNONYM Dp38
2007-11-08 Added SYNONYM ERK
2007-11-08 Added SYNONYM LeMPK3
2007-11-08 Added SYNONYM MAP-2 kinase activity
2007-11-08 Added SYNONYM MAPK
2007-11-08 Added SYNONYM MBP kinase I activity
2007-11-08 Added SYNONYM MBP kinase II activity
2007-11-08 Added SYNONYM PMK-1
2007-11-08 Added SYNONYM PMK-2
2007-11-08 Added SYNONYM PMK-3
2007-11-08 Added SYNONYM STK26
2007-11-08 Added SYNONYM extracellular signal-regulated kinase activity
2007-11-08 Added SYNONYM microtubule-associated protein 2 kinase activity
2007-11-08 Added SYNONYM microtubule-associated protein kinase activity
2007-11-08 Added SYNONYM mitogen activated kinase activity
2007-11-08 Added SYNONYM mitogen-activated protein kinase activity
2007-11-08 Added SYNONYM myelin basic protein kinase activity
2007-11-08 Added SYNONYM p38-2
2007-11-08 Added SYNONYM p38delta
2007-11-08 Added SYNONYM p42 mitogen-activated protein kinase activity
2007-11-08 Added SYNONYM p42mapk
2007-11-08 Added SYNONYM p44mpk
2007-11-08 Added SYNONYM pp42
2007-11-08 Added SYNONYM pp44mapk
2007-11-08 Deleted SYNONYM MAPK
2007-11-08 Deleted SYNONYM mitogen activated kinase
2007-09-26 Added XREF EC:2.7.11.24
2007-09-26 Deleted XREF EC:2.7.1.-
2007-08-09 Added SYNONYM MAPK
2007-08-09 Added SYNONYM mitogen activated kinase
2007-08-09 Deleted SYNONYM MAPK
2007-08-09 Deleted SYNONYM mitogen activated kinase
2004-04-19 Added SYNONYM MAPK
2004-04-19 Added SYNONYM mitogen activated kinase
2004-04-16 Deleted SYNONYM MAPK
2004-04-16 Deleted SYNONYM mitogen activated kinase
2003-08-06 Updated DEFINITION Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2003-04-12 Deleted SYNONYM MEK
2003-03-19 Updated TERM MAP kinase activity
2002-11-27 Updated DEFINITION Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2002-02-06 Updated TERM MAP kinase
2001-08-06 Added DEFINITION Abbr. for mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumour- promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2001-04-03 Updated TERM MAP kinase
2001-03-30 Added XREF EC:2.7.1.-
2001-03-30 Added SYNONYM MAPK
2001-03-30 Added SYNONYM MEK
2001-03-30 Added SYNONYM mitogen activated kinase
2001-03-30 Added TERM MAP kinase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM MAP kinase activity
2002-02-06 Updated TERM MAP kinase
2001-04-03 Updated TERM MAP kinase
2001-03-30 Added TERM MAP kinase

Definition/synonyms

Timestamp Action Category Detail
2010-10-13 Added SYNONYM ERK2
2010-10-13 Added SYNONYM MAP kinase 2 activity
2010-10-13 Added SYNONYM SAPK2
2010-10-13 Added SYNONYM p38
2010-10-13 Added SYNONYM MP kinase activity
2010-10-13 Added SYNONYM Mpk2
2010-10-13 Added SYNONYM MAP kinase 1 activity
2010-10-13 Added SYNONYM ERK1
2010-09-15 Added DEFINITION Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2010-09-15 Deleted DEFINITION Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2008-06-03 Deleted SYNONYM microtubule-associated protein 2 kinase activity
2008-06-03 Deleted SYNONYM microtubule-associated protein kinase activity
2008-05-13 Added DEFINITION Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2008-05-12 Deleted DEFINITION Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2007-11-08 Added SYNONYM ATP:protein phosphotransferase (MAPKK-activated) activity
2007-11-08 Added SYNONYM Dp38
2007-11-08 Added SYNONYM ERK
2007-11-08 Added SYNONYM LeMPK3
2007-11-08 Added SYNONYM MAP-2 kinase activity
2007-11-08 Added SYNONYM MAPK
2007-11-08 Added SYNONYM MBP kinase I activity
2007-11-08 Added SYNONYM MBP kinase II activity
2007-11-08 Added SYNONYM PMK-1
2007-11-08 Added SYNONYM PMK-2
2007-11-08 Added SYNONYM PMK-3
2007-11-08 Added SYNONYM STK26
2007-11-08 Added SYNONYM extracellular signal-regulated kinase activity
2007-11-08 Added SYNONYM microtubule-associated protein 2 kinase activity
2007-11-08 Added SYNONYM microtubule-associated protein kinase activity
2007-11-08 Added SYNONYM mitogen activated kinase activity
2007-11-08 Added SYNONYM mitogen-activated protein kinase activity
2007-11-08 Added SYNONYM myelin basic protein kinase activity
2007-11-08 Added SYNONYM p38-2
2007-11-08 Added SYNONYM p38delta
2007-11-08 Added SYNONYM p42 mitogen-activated protein kinase activity
2007-11-08 Added SYNONYM p42mapk
2007-11-08 Added SYNONYM p44mpk
2007-11-08 Added SYNONYM pp42
2007-11-08 Added SYNONYM pp44mapk
2007-11-08 Deleted SYNONYM MAPK
2007-11-08 Deleted SYNONYM mitogen activated kinase
2007-08-09 Added SYNONYM MAPK
2007-08-09 Added SYNONYM mitogen activated kinase
2007-08-09 Deleted SYNONYM MAPK
2007-08-09 Deleted SYNONYM mitogen activated kinase
2004-04-19 Added SYNONYM MAPK
2004-04-19 Added SYNONYM mitogen activated kinase
2004-04-16 Deleted SYNONYM MAPK
2004-04-16 Deleted SYNONYM mitogen activated kinase
2003-08-06 Updated DEFINITION Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2003-04-12 Deleted SYNONYM MEK
2002-11-27 Updated DEFINITION Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2001-08-06 Added DEFINITION Abbr. for mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumour- promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2001-03-30 Added SYNONYM MAPK
2001-03-30 Added SYNONYM MEK
2001-03-30 Added SYNONYM mitogen activated kinase

Relationships

Timestamp Action Category Detail
2012-01-29 Added RELATION part of GO:0000165 (MAPK cascade)
2008-04-01 Updated RELATION is a GO:0004702 (receptor signaling protein serine/threonine kinase activity)

Cross-references

Timestamp Action Category Detail
2011-05-03 Deleted XREF EC:2.7.11.-
2010-10-13 Added XREF EC:2.7.11.-
2010-09-15 Added XREF KEGG:R00162
2009-05-21 Added XREF MetaCyc:2.7.11.24-RXN
2007-09-26 Added XREF EC:2.7.11.24
2007-09-26 Deleted XREF EC:2.7.1.-
2001-03-30 Added XREF EC:2.7.1.-

Other

Timestamp Action Category Detail
2010-10-13 Added SECONDARY GO:0016908 (MAP kinase 2 activity)
2010-10-13 Added SECONDARY GO:0008339 (MP kinase activity)
2010-10-13 Added SECONDARY GO:0008338 (MAP kinase 1 activity)
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