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GO:0008278 cohesin complex

Term Information

ID GO:0008278
Name cohesin complex
Ontology Cellular Component
Definition A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
PMID:9887095
Secondary IDs GO:0008279 GO:0043222
GONUTS GO:0008278 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related SMC complex
narrow 14S cohesin
exact SMC/kleisin ring complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_pir462

Cross-references

Database ID
InterPro IPR028468

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008278:
Relationship To GO:0008278 Child Term Child Term Name
Is a GO:0000798 nuclear cohesin complex
Part of GO:0008280 cohesin core heterodimer
Is a GO:0030892 mitotic cohesin complex
Is a GO:0030893 meiotic cohesin complex

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008278. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008278 based on the entire annotation set Co-occurrence statistics for GO:0008278 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_pir
2011-02-15 Added SECONDARY GO:0043222 (SMC/kleisin ring complex)
2011-02-15 Added RELATION part of GO:0000793 (condensed chromosome)
2011-02-15 Added SYNONYM SMC/kleisin ring complex
2011-02-15 Added DEFINITION A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
2011-02-15 Deleted DEFINITION A protein complex required for sister chromatid cohesion in eukaryotes.
2008-06-09 Added SLIM goslim_pir
2008-05-13 Added DEFINITION A protein complex required for sister chromatid cohesion in eukaryotes.
2008-05-12 Deleted DEFINITION A protein complex required for sister chromatid cohesion in eukaryotes.
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044427 (chromosomal part)
2007-08-09 Added SYNONYM 14S cohesin
2007-08-09 Added SYNONYM SMC complex
2007-08-09 Deleted SYNONYM 14S cohesin
2007-08-09 Deleted SYNONYM SMC complex
2005-03-27 Added SYNONYM SMC complex
2004-04-19 Added SYNONYM 14S cohesin
2004-04-16 Deleted SYNONYM 14S cohesin
2002-12-14 Updated TERM cohesin complex
2002-11-27 Updated DEFINITION A protein complex required for sister chromatid cohesion in eukaryotes.
2002-03-25 Added SYNONYM 14S cohesin
2002-03-25 Added SECONDARY GO:0008279 (14S cohesin)
2002-02-06 Updated TERM cohesin
2001-08-06 Added DEFINITION Cohesins are the most abundant structural components of mitotic chromosomes and play a role in driving chromosome condensation.
2001-04-03 Updated TERM cohesin
2001-03-30 Added TERM cohesin

Term

Timestamp Action Category Detail
2002-12-14 Updated TERM cohesin complex
2002-02-06 Updated TERM cohesin
2001-04-03 Updated TERM cohesin
2001-03-30 Added TERM cohesin

Definition/synonyms

Timestamp Action Category Detail
2011-02-15 Added SYNONYM SMC/kleisin ring complex
2011-02-15 Added DEFINITION A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
2011-02-15 Deleted DEFINITION A protein complex required for sister chromatid cohesion in eukaryotes.
2008-05-13 Added DEFINITION A protein complex required for sister chromatid cohesion in eukaryotes.
2008-05-12 Deleted DEFINITION A protein complex required for sister chromatid cohesion in eukaryotes.
2007-08-09 Added SYNONYM 14S cohesin
2007-08-09 Added SYNONYM SMC complex
2007-08-09 Deleted SYNONYM 14S cohesin
2007-08-09 Deleted SYNONYM SMC complex
2005-03-27 Added SYNONYM SMC complex
2004-04-19 Added SYNONYM 14S cohesin
2004-04-16 Deleted SYNONYM 14S cohesin
2002-11-27 Updated DEFINITION A protein complex required for sister chromatid cohesion in eukaryotes.
2002-03-25 Added SYNONYM 14S cohesin
2001-08-06 Added DEFINITION Cohesins are the most abundant structural components of mitotic chromosomes and play a role in driving chromosome condensation.

Relationships

Timestamp Action Category Detail
2011-02-15 Added RELATION part of GO:0000793 (condensed chromosome)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044427 (chromosomal part)

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_pir
2011-02-15 Added SECONDARY GO:0043222 (SMC/kleisin ring complex)
2008-06-09 Added SLIM goslim_pir
2002-03-25 Added SECONDARY GO:0008279 (14S cohesin)
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