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GO:0008237 metallopeptidase activity

Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Term Information

ID GO:0008237
Name metallopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Comment

Synonyms

Type Synonym
exact metalloprotease activity
exact metalloproteinase activity

Cross-references associated with this term:

Database ID
INTERPRO IPR013277
INTERPRO IPR001548
INTERPRO IPR001261
INTERPRO IPR008753
INTERPRO IPR014782
INTERPRO IPR013273
INTERPRO IPR013274
INTERPRO IPR013275
INTERPRO IPR013276
INTERPRO IPR012962
INTERPRO IPR013647
INTERPRO IPR012091
INTERPRO IPR015211
INTERPRO IPR013578
INTERPRO IPR006025
INTERPRO IPR006026
INTERPRO IPR002933
INTERPRO IPR000755
INTERPRO IPR005075

This term can be used instead of these obsolete terms:

GO:0004246 peptidyl-dipeptidase A activity (replaced_by GO:0008237)
GO:0016921 pyroglutamyl-peptidase II activity (replaced_by GO:0008237)
GO:0017092 sterol regulatory element-binding protein site 2 protease activity (replaced_by GO:0008237)

Web service: term information

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Ancestor Chart

Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term. Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms by one or more 'relationships'

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0008233 peptidase activity
GO:0070011 peptidase activity, acting on L-amino acid peptides
GO:0008237 metallopeptidase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0004222 metalloendopeptidase activity
I GO:0008235 metalloexopeptidase activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.
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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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