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GO:0008236 serine-type peptidase activity

Term Information

ID GO:0008236
Name serine-type peptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
GONUTS GO:0008236 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact serine protease activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR000126
InterPro IPR000223
InterPro IPR001375
InterPro IPR004109
InterPro IPR004236
InterPro IPR004447
InterPro IPR005151
InterPro IPR005320
InterPro IPR008256
InterPro IPR008758
InterPro IPR012393
InterPro IPR015366
InterPro IPR019756
InterPro IPR019757
InterPro IPR019758
UniProtKB-KW Serine protease

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004274 dipeptidyl-peptidase IV activity REPLACEDBY GO:0008236
GO:0017094 sterol regulatory element-binding protein site 1 protease activity REPLACEDBY GO:0008236
GO:0043859 cyanophycinase activity REPLACEDBY GO:0008236

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008236:
Relationship To GO:0008236 Child Term Child Term Name
Is a GO:0008240 tripeptidyl-peptidase activity
Is a GO:0004252 serine-type endopeptidase activity
Is a GO:0070008 serine-type exopeptidase activity
Regulates GO:1902571 regulation of serine-type peptidase activity
Negatively regulates GO:1902572 negative regulation of serine-type peptidase activity
Positively regulates GO:1902573 positive regulation of serine-type peptidase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008236. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008236 based on the entire annotation set Co-occurrence statistics for GO:0008236 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-08-18 Deleted RELATION is a GO:0008233 (peptidase activity)
2008-08-18 Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-04-01 Updated RELATION is a GO:0008233 (peptidase activity)
2008-04-01 Updated RELATION is a GO:0017171 (serine hydrolase activity)
2007-11-08 Deleted SYNONYM serine protease
2007-11-08 Added SYNONYM serine protease activity
2007-08-09 Added SYNONYM serine protease
2007-08-09 Deleted SYNONYM serine protease
2007-06-27 Updated DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2004-04-19 Added SYNONYM serine protease
2004-04-16 Deleted SYNONYM serine protease
2003-11-26 Updated DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active centre.
2003-03-19 Updated TERM serine-type peptidase activity
2002-02-06 Updated TERM serine-type peptidase
2001-04-03 Updated TERM serine-type peptidase
2001-03-30 Added SYNONYM serine protease
2001-03-30 Added TERM serine-type peptidase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM serine-type peptidase activity
2002-02-06 Updated TERM serine-type peptidase
2001-04-03 Updated TERM serine-type peptidase
2001-03-30 Added TERM serine-type peptidase

Definition/synonyms

Timestamp Action Category Detail
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2007-11-08 Deleted SYNONYM serine protease
2007-11-08 Added SYNONYM serine protease activity
2007-08-09 Added SYNONYM serine protease
2007-08-09 Deleted SYNONYM serine protease
2007-06-27 Updated DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2004-04-19 Added SYNONYM serine protease
2004-04-16 Deleted SYNONYM serine protease
2003-11-26 Updated DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active centre.
2001-03-30 Added SYNONYM serine protease

Relationships

Timestamp Action Category Detail
2008-08-18 Deleted RELATION is a GO:0008233 (peptidase activity)
2008-08-18 Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-04-01 Updated RELATION is a GO:0008233 (peptidase activity)
2008-04-01 Updated RELATION is a GO:0017171 (serine hydrolase activity)
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