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GO:0008235 metalloexopeptidase activity

Term Information

ID GO:0008235
Name metalloexopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GONUTS GO:0008235 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR000180
InterPro IPR001714
InterPro IPR002467
InterPro IPR002468
InterPro IPR008330
InterPro IPR011356

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004178 leucyl aminopeptidase activity REPLACEDBY GO:0008235
GO:0004179 membrane alanyl aminopeptidase activity REPLACEDBY GO:0008235
GO:0004230 glutamyl aminopeptidase activity REPLACEDBY GO:0008235
GO:0004237 membrane dipeptidase activity REPLACEDBY GO:0008235
GO:0004239 methionyl aminopeptidase activity REPLACEDBY GO:0008235
GO:0004250 aminopeptidase I activity REPLACEDBY GO:0008235
GO:0004251 X-Pro dipeptidase activity REPLACEDBY GO:0008235
GO:0008769 X-His dipeptidase activity REPLACEDBY GO:0008235
GO:0008956 peptidyl-dipeptidase Dcp activity REPLACEDBY GO:0008235
GO:0016284 alanine aminopeptidase activity REPLACEDBY GO:0008235
GO:0016285 cytosol alanyl aminopeptidase activity REPLACEDBY GO:0008235

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008235:
Relationship To GO:0008235 Child Term Child Term Name
Is a GO:0004181 metallocarboxypeptidase activity
Is a GO:0070573 metallodipeptidase activity
Is a GO:0070006 metalloaminopeptidase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008235. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008235 based on the entire annotation set Co-occurrence statistics for GO:0008235 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-04-01 Updated RELATION is a GO:0008238 (exopeptidase activity)
2008-04-01 Updated RELATION is a GO:0008237 (metallopeptidase activity)
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2003-03-19 Updated TERM metalloexopeptidase activity
2002-02-06 Updated TERM metalloexopeptidase
2001-04-03 Updated TERM metalloexopeptidase
2001-03-30 Added TERM metalloexopeptidase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM metalloexopeptidase activity
2002-02-06 Updated TERM metalloexopeptidase
2001-04-03 Updated TERM metalloexopeptidase
2001-03-30 Added TERM metalloexopeptidase

Definition/synonyms

Timestamp Action Category Detail
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008238 (exopeptidase activity)
2008-04-01 Updated RELATION is a GO:0008237 (metallopeptidase activity)
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