spacer

GO:0008234 cysteine-type peptidase activity

Term Information

ID GO:0008234
Name cysteine-type peptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
Secondary IDs GO:0004220
GONUTS GO:0008234 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow cysteine protease activity
narrow thiol protease activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.4.-.-
InterPro IPR000200
InterPro IPR000668
InterPro IPR001730
InterPro IPR001769
InterPro IPR002527
InterPro IPR002705
InterPro IPR003653
InterPro IPR005897
InterPro IPR008750
InterPro IPR013016
InterPro IPR013128
InterPro IPR015643
InterPro IPR015644
InterPro IPR015645
InterPro IPR015917
InterPro IPR025773
InterPro IPR029762
InterPro IPR033157
InterPro IPR033158
InterPro IPR033296
InterPro IPR033387
InterPro IPR033502
InterPro IPR033838
InterPro IPR033839
UniProtKB-KW Thiol protease

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004214 obsolete dipeptidyl-peptidase I activity CONSIDER GO:0008234
GO:0004219 obsolete pyroglutamyl-peptidase I activity CONSIDER GO:0008234

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008234:
Relationship To GO:0008234 Child Term Child Term Name
Is a GO:0019783 ubiquitin-like protein-specific protease activity
Negatively regulates GO:0004869 cysteine-type endopeptidase inhibitor activity
Is a GO:0004197 cysteine-type endopeptidase activity
Is a GO:0070004 cysteine-type exopeptidase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008234. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008234 based on the entire annotation set Co-occurrence statistics for GO:0008234 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-02-14 Added SYNONYM cysteine protease activity
2016-02-14 Added SYNONYM thiol protease activity
2016-02-14 Deleted SYNONYM thiol protease activity
2016-02-14 Deleted SYNONYM cysteine protease activity
2008-08-18 Deleted RELATION is a GO:0008233 (peptidase activity)
2008-08-18 Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-04-01 Updated RELATION is a GO:0008233 (peptidase activity)
2007-11-08 Deleted SYNONYM cysteine protease
2007-11-08 Deleted SYNONYM thiol protease
2007-11-08 Added SYNONYM cysteine protease activity
2007-11-08 Added SYNONYM thiol protease activity
2007-08-09 Added SYNONYM cysteine protease
2007-08-09 Added SYNONYM thiol protease
2007-08-09 Deleted SYNONYM cysteine protease
2007-08-09 Deleted SYNONYM thiol protease
2004-04-19 Added SYNONYM cysteine protease
2004-04-19 Added SYNONYM thiol protease
2004-04-16 Deleted SYNONYM cysteine protease
2004-04-16 Deleted SYNONYM thiol protease
2003-11-26 Updated DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active centre.
2003-03-19 Updated TERM cysteine-type peptidase activity
2002-11-05 Added XREF EC:3.4.-.-
2002-02-06 Updated TERM cysteine-type peptidase
2001-12-17 Added SYNONYM cysteine protease
2001-12-17 Added SYNONYM thiol protease
2001-12-17 Added SECONDARY GO:0004220 (thiol protease)
2001-04-03 Updated TERM cysteine-type peptidase
2001-03-30 Added TERM cysteine-type peptidase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM cysteine-type peptidase activity
2002-02-06 Updated TERM cysteine-type peptidase
2001-04-03 Updated TERM cysteine-type peptidase
2001-03-30 Added TERM cysteine-type peptidase

Definition/synonyms

Timestamp Action Category Detail
2016-02-14 Added SYNONYM cysteine protease activity
2016-02-14 Added SYNONYM thiol protease activity
2016-02-14 Deleted SYNONYM thiol protease activity
2016-02-14 Deleted SYNONYM cysteine protease activity
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2007-11-08 Deleted SYNONYM cysteine protease
2007-11-08 Deleted SYNONYM thiol protease
2007-11-08 Added SYNONYM cysteine protease activity
2007-11-08 Added SYNONYM thiol protease activity
2007-08-09 Added SYNONYM cysteine protease
2007-08-09 Added SYNONYM thiol protease
2007-08-09 Deleted SYNONYM cysteine protease
2007-08-09 Deleted SYNONYM thiol protease
2004-04-19 Added SYNONYM cysteine protease
2004-04-19 Added SYNONYM thiol protease
2004-04-16 Deleted SYNONYM cysteine protease
2004-04-16 Deleted SYNONYM thiol protease
2003-11-26 Updated DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active centre.
2001-12-17 Added SYNONYM cysteine protease
2001-12-17 Added SYNONYM thiol protease

Relationships

Timestamp Action Category Detail
2008-08-18 Deleted RELATION is a GO:0008233 (peptidase activity)
2008-08-18 Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-04-01 Updated RELATION is a GO:0008233 (peptidase activity)

Cross-references

Timestamp Action Category Detail
2002-11-05 Added XREF EC:3.4.-.-

Other

Timestamp Action Category Detail
2001-12-17 Added SECONDARY GO:0004220 (thiol protease)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
15ms