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GO:0008233 peptidase activity

Term Information

ID GO:0008233
Name peptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
GONUTS GO:0008233 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow protease activity
exact hydrolase, acting on peptide bonds
narrow proteinase activity
exact peptide hydrolase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_metagenomics116
goslim_generic149
goslim_pir462
goslim_yeast169
goslim_candida89
goslim_chembl309
goslim_aspergillus85

Cross-references

Database ID
EC 3.4
InterPro IPR000081
InterPro IPR000671
InterPro IPR001096
InterPro IPR001539
InterPro IPR001733
InterPro IPR001767
InterPro IPR002142
InterPro IPR002410
InterPro IPR002527
InterPro IPR003709
InterPro IPR004411
InterPro IPR004420
InterPro IPR004634
InterPro IPR004635
InterPro IPR005074
InterPro IPR005080
InterPro IPR005314
InterPro IPR005536
InterPro IPR005945
InterPro IPR006741
InterPro IPR006928
InterPro IPR007544
InterPro IPR007653
InterPro IPR008757
InterPro IPR009542
InterPro IPR009582
InterPro IPR010909
InterPro IPR011813
InterPro IPR011816
InterPro IPR015117
InterPro IPR022366
InterPro IPR023338
InterPro IPR023596
InterPro IPR026730
InterPro IPR026898
InterPro IPR027057
InterPro IPR028130
InterPro IPR028533
InterPro IPR029761
InterPro IPR030397
InterPro IPR031245
InterPro IPR033083
InterPro IPR033161
InterPro IPR033477
UniProtKB-KW Protease

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004299 obsolete proteasome endopeptidase activity CONSIDER GO:0008233
GO:0031368 obsolete Pro-X metallocarboxypeptidase activity CONSIDER GO:0008233
GO:0009003 obsolete signal peptidase activity REPLACEDBY GO:0008233

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008233:
Relationship To GO:0008233 Child Term Child Term Name
Is a GO:0070122 isopeptidase activity
Negatively regulates GO:0010466 negative regulation of peptidase activity
Positively regulates GO:0010952 positive regulation of peptidase activity
Positively regulates GO:0016504 peptidase activator activity
Negatively regulates GO:0030414 peptidase inhibitor activity
Regulates GO:0052547 regulation of peptidase activity
Regulates GO:0061134 peptidase regulator activity
Is a GO:0070010 peptidase activity, acting on D-amino acid peptides
Is a GO:0070011 peptidase activity, acting on L-amino acid peptides
Is a GO:0070012 oligopeptidase activity
Capable of GO:1905368 peptidase complex
Negatively regulates GO:0052404 negative regulation by host of symbiont peptidase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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ID Mapping

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008233. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008233 based on the entire annotation set Co-occurrence statistics for GO:0008233 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-02-14 Added SYNONYM protease activity
2016-02-14 Added SYNONYM proteinase activity
2016-02-14 Deleted SYNONYM proteinase activity
2016-02-14 Deleted SYNONYM protease activity
2015-05-19 Added SLIM goslim_chembl
2015-05-19 Deleted SLIM goslim_ChEMBL
2015-05-11 Added SLIM goslim_ChEMBL
2014-03-07 Added RELATION part of GO:0006508 (proteolysis)
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-11-05 Added SLIM goslim_aspergillus
2010-12-05 Deleted SLIM goslim_generic
2008-08-18 Added SYNONYM proteinase activity
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds.
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_generic
2008-06-09 Added SLIM goslim_candida
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of peptide bonds.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds.
2008-04-01 Updated RELATION is a GO:0016787 (hydrolase activity)
2007-11-08 Deleted SYNONYM peptide hydrolase
2007-11-08 Deleted SYNONYM protease
2007-11-08 Added SYNONYM peptide hydrolase activity
2007-11-08 Added SYNONYM protease activity
2007-11-08 Added XREF EC:3.4
2007-11-08 Deleted XREF EC:3.4.-.-
2007-10-11 Deleted SYNONYM proteasome endopeptidase activity
2007-08-09 Added SYNONYM hydrolase, acting on peptide bonds
2007-08-09 Added SYNONYM peptide hydrolase
2007-08-09 Added SYNONYM protease
2007-08-09 Added SYNONYM proteasome endopeptidase activity
2007-08-09 Deleted SYNONYM hydrolase, acting on peptide bonds
2007-08-09 Deleted SYNONYM peptide hydrolase
2007-08-09 Deleted SYNONYM protease
2007-08-09 Deleted SYNONYM proteasome endopeptidase activity
2005-08-10 Added SYNONYM proteasome endopeptidase activity
2004-04-19 Added SYNONYM hydrolase, acting on peptide bonds
2004-04-19 Added SYNONYM peptide hydrolase
2004-04-19 Added SYNONYM protease
2004-04-16 Deleted SYNONYM hydrolase, acting on peptide bonds
2004-04-16 Deleted SYNONYM peptide hydrolase
2004-04-16 Deleted SYNONYM protease
2003-03-19 Updated TERM peptidase activity
2002-11-27 Added DEFINITION Catalysis of the hydrolysis of peptide bonds.
2002-02-14 Added SYNONYM peptide hydrolase
2002-02-06 Updated TERM peptidase
2001-04-03 Updated TERM peptidase
2001-03-30 Added XREF EC:3.4.-.-
2001-03-30 Added SYNONYM hydrolase, acting on peptide bonds
2001-03-30 Added SYNONYM protease
2001-03-30 Added TERM peptidase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM peptidase activity
2002-02-06 Updated TERM peptidase
2001-04-03 Updated TERM peptidase
2001-03-30 Added TERM peptidase

Definition/synonyms

Timestamp Action Category Detail
2016-02-14 Added SYNONYM protease activity
2016-02-14 Added SYNONYM proteinase activity
2016-02-14 Deleted SYNONYM proteinase activity
2016-02-14 Deleted SYNONYM protease activity
2008-08-18 Added SYNONYM proteinase activity
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of peptide bonds.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of peptide bonds.
2007-11-08 Deleted SYNONYM peptide hydrolase
2007-11-08 Deleted SYNONYM protease
2007-11-08 Added SYNONYM peptide hydrolase activity
2007-11-08 Added SYNONYM protease activity
2007-10-11 Deleted SYNONYM proteasome endopeptidase activity
2007-08-09 Added SYNONYM hydrolase, acting on peptide bonds
2007-08-09 Added SYNONYM peptide hydrolase
2007-08-09 Added SYNONYM protease
2007-08-09 Added SYNONYM proteasome endopeptidase activity
2007-08-09 Deleted SYNONYM hydrolase, acting on peptide bonds
2007-08-09 Deleted SYNONYM peptide hydrolase
2007-08-09 Deleted SYNONYM protease
2007-08-09 Deleted SYNONYM proteasome endopeptidase activity
2005-08-10 Added SYNONYM proteasome endopeptidase activity
2004-04-19 Added SYNONYM hydrolase, acting on peptide bonds
2004-04-19 Added SYNONYM peptide hydrolase
2004-04-19 Added SYNONYM protease
2004-04-16 Deleted SYNONYM hydrolase, acting on peptide bonds
2004-04-16 Deleted SYNONYM peptide hydrolase
2004-04-16 Deleted SYNONYM protease
2002-11-27 Added DEFINITION Catalysis of the hydrolysis of peptide bonds.
2002-02-14 Added SYNONYM peptide hydrolase
2001-03-30 Added SYNONYM hydrolase, acting on peptide bonds
2001-03-30 Added SYNONYM protease

Relationships

Timestamp Action Category Detail
2014-03-07 Added RELATION part of GO:0006508 (proteolysis)
2008-04-01 Updated RELATION is a GO:0016787 (hydrolase activity)

Cross-references

Timestamp Action Category Detail
2007-11-08 Added XREF EC:3.4
2007-11-08 Deleted XREF EC:3.4.-.-
2001-03-30 Added XREF EC:3.4.-.-

Other

Timestamp Action Category Detail
2015-05-19 Added SLIM goslim_chembl
2015-05-19 Deleted SLIM goslim_ChEMBL
2015-05-11 Added SLIM goslim_ChEMBL
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-11-05 Added SLIM goslim_aspergillus
2010-12-05 Deleted SLIM goslim_generic
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_generic
2008-06-09 Added SLIM goslim_candida
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