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GO:0008219 cell death

Term Information

ID GO:0008219
Name cell death
Ontology Biological Process
Definition Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
Comment This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
GONUTS GO:0008219 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related necrosis
related accidental cell death

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_generic149
goslim_plant100

Cross-references

Database ID
InterPro IPR000753
InterPro IPR015290
UniProtKB-KW Neurodegeneration

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0008220 necrosis CONSIDER GO:0008219

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008219:
Relationship To GO:0008219 Child Term Child Term Name
Is a GO:0012501 programmed cell death
Is a GO:0070265 necrotic cell death
Positively regulates GO:0010942 positive regulation of cell death
Negatively regulates GO:0060548 negative regulation of cell death
Is a GO:0070997 neuron death
Regulates GO:0010941 regulation of cell death
Is a GO:0036473 cell death in response to oxidative stress

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
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Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008219. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008219 based on the entire annotation set Co-occurrence statistics for GO:0008219 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_plant
2013-04-18 Updated SLIM goslim_generic
2013-03-10 Added SYNONYM accidental cell death
2012-12-15 Added RELATION is a GO:0044763 (single-organism cellular process)
2012-12-15 Deleted RELATION is a GO:0009987 (cellular process)
2011-11-24 Deleted DEFINITION A biological process that results in permanent cessation of all vital functions of a cell.
2011-11-24 Added DEFINITION Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
2011-03-18 Deleted SLIM goslim_goa
2010-02-04 Deleted DEFINITION The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2010-02-04 Added DEFINITION A biological process that results in permanent cessation of all vital functions of a cell.
2008-06-30 Added RELATION is a GO:0009987 (cellular process)
2008-06-30 Deleted RELATION is a GO:0048869 (cellular developmental process)
2008-06-30 Deleted RELATION part of GO:0048468 (cell development)
2008-06-09 Added SLIM goslim_plant
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_generic
2008-05-13 Added DEFINITION The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2008-05-12 Deleted DEFINITION The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2008-04-01 Updated RELATION is a GO:0016265 (death)
2008-04-01 Updated RELATION is a GO:0048869 (cellular developmental process)
2008-04-01 Updated RELATION part of GO:0048468 (cell development)
2007-08-09 Added SYNONYM necrosis
2007-08-09 Deleted SYNONYM necrosis
2005-08-10 Added SYNONYM necrosis
2004-09-29 Updated TERM cell death
2002-11-27 Added DEFINITION The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2002-02-06 Updated TERM cell death
2001-04-03 Updated TERM cell death
2001-03-30 Added TERM cell death

Term

Timestamp Action Category Detail
2004-09-29 Updated TERM cell death
2002-02-06 Updated TERM cell death
2001-04-03 Updated TERM cell death
2001-03-30 Added TERM cell death

Definition/synonyms

Timestamp Action Category Detail
2013-03-10 Added SYNONYM accidental cell death
2011-11-24 Deleted DEFINITION A biological process that results in permanent cessation of all vital functions of a cell.
2011-11-24 Added DEFINITION Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
2010-02-04 Deleted DEFINITION The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2010-02-04 Added DEFINITION A biological process that results in permanent cessation of all vital functions of a cell.
2008-05-13 Added DEFINITION The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2008-05-12 Deleted DEFINITION The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2007-08-09 Added SYNONYM necrosis
2007-08-09 Deleted SYNONYM necrosis
2005-08-10 Added SYNONYM necrosis
2002-11-27 Added DEFINITION The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

Relationships

Timestamp Action Category Detail
2012-12-15 Added RELATION is a GO:0044763 (single-organism cellular process)
2012-12-15 Deleted RELATION is a GO:0009987 (cellular process)
2008-06-30 Added RELATION is a GO:0009987 (cellular process)
2008-06-30 Deleted RELATION is a GO:0048869 (cellular developmental process)
2008-06-30 Deleted RELATION part of GO:0048468 (cell development)
2008-04-01 Updated RELATION is a GO:0016265 (death)
2008-04-01 Updated RELATION is a GO:0048869 (cellular developmental process)
2008-04-01 Updated RELATION part of GO:0048468 (cell development)

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_plant
2013-04-18 Updated SLIM goslim_generic
2011-03-18 Deleted SLIM goslim_goa
2008-06-09 Added SLIM goslim_plant
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_generic
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