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GO:0008191 metalloendopeptidase inhibitor activity

Term Information

ID GO:0008191
Name metalloendopeptidase inhibitor activity
Ontology Molecular Function
Definition Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
GONUTS GO:0008191 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad metalloprotease inhibitor
broad metalloproteinase inhibitor

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR001820
UniProtKB-KW Metalloprotease inhibitor

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008191:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008191. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008191 based on the entire annotation set Co-occurrence statistics for GO:0008191 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-06-15 Added RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2010-06-08 Added RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2009-03-16 Added RELATION is a GO:0048551 (metalloenzyme inhibitor activity)
2009-02-25 Deleted RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2009-02-22 Added RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2008-08-18 Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-08-18 Deleted DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-04-01 Updated RELATION is a GO:0004866 (endopeptidase inhibitor activity)
2007-08-09 Added SYNONYM metalloprotease inhibitor
2007-08-09 Added SYNONYM metalloproteinase inhibitor
2007-08-09 Deleted SYNONYM metalloprotease inhibitor
2007-08-09 Deleted SYNONYM metalloproteinase inhibitor
2004-04-19 Added SYNONYM metalloprotease inhibitor
2004-04-19 Added SYNONYM metalloproteinase inhibitor
2004-04-16 Deleted SYNONYM metalloprotease inhibitor
2004-04-16 Deleted SYNONYM metalloproteinase inhibitor
2004-01-08 Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2003-03-19 Updated TERM metalloendopeptidase inhibitor activity
2003-03-19 Deleted SYNONYM metalloendopeptidase inhibitor
2002-07-09 Updated TERM metalloendopeptidase inhibitor
2002-07-09 Added SYNONYM metalloprotease inhibitor
2002-07-09 Added SYNONYM metalloproteinase inhibitor
2002-02-06 Updated TERM metalloprotease inhibitor
2001-08-22 Added SYNONYM metalloendopeptidase inhibitor
2001-04-03 Updated TERM metalloprotease inhibitor
2001-03-30 Added TERM metalloprotease inhibitor

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM metalloendopeptidase inhibitor activity
2002-07-09 Updated TERM metalloendopeptidase inhibitor
2002-02-06 Updated TERM metalloprotease inhibitor
2001-04-03 Updated TERM metalloprotease inhibitor
2001-03-30 Added TERM metalloprotease inhibitor

Definition/synonyms

Timestamp Action Category Detail
2008-08-18 Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-08-18 Deleted DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2007-08-09 Added SYNONYM metalloprotease inhibitor
2007-08-09 Added SYNONYM metalloproteinase inhibitor
2007-08-09 Deleted SYNONYM metalloprotease inhibitor
2007-08-09 Deleted SYNONYM metalloproteinase inhibitor
2004-04-19 Added SYNONYM metalloprotease inhibitor
2004-04-19 Added SYNONYM metalloproteinase inhibitor
2004-04-16 Deleted SYNONYM metalloprotease inhibitor
2004-04-16 Deleted SYNONYM metalloproteinase inhibitor
2004-01-08 Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2003-03-19 Deleted SYNONYM metalloendopeptidase inhibitor
2002-07-09 Added SYNONYM metalloprotease inhibitor
2002-07-09 Added SYNONYM metalloproteinase inhibitor
2001-08-22 Added SYNONYM metalloendopeptidase inhibitor

Relationships

Timestamp Action Category Detail
2010-06-15 Added RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2010-06-08 Added RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2009-03-16 Added RELATION is a GO:0048551 (metalloenzyme inhibitor activity)
2009-02-25 Deleted RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2009-02-22 Added RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2008-04-01 Updated RELATION is a GO:0004866 (endopeptidase inhibitor activity)
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