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GO:0008180 COP9 signalosome

Term Information

ID GO:0008180
Name COP9 signalosome
Ontology Cellular Component
Definition A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
PMID:11019806 PMID:12186635 PMID:14570571
GONUTS GO:0008180 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad signalosome
exact COP9 complex
exact CSN

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
GOTAX:0000059 GO:0005634 nucleus only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Protein complexes

Database ID Name
IntAct cop9_human-1 COP9 signalosome variant 1
IntAct cop9_human-2 COP9 signalosome variant 2
IntAct cop9_yeast COP9 signalosome

Cross-references

Database ID
InterPro IPR016806
InterPro IPR027530
UniProtKB-KW Signalosome

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008180:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
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Qualifier
GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Name
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Taxon Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008180. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008180 based on the entire annotation set Co-occurrence statistics for GO:0008180 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-07-22 Deleted SYNONYM COP9 complex
2013-07-22 Added SYNONYM signalosome
2013-07-22 Updated TERM COP9 signalosome
2013-07-22 Added SYNONYM COP9 complex
2008-05-13 Added DEFINITION A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2008-05-12 Deleted DEFINITION A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044428 (nuclear part)
2007-08-09 Added SYNONYM COP9 complex
2007-08-09 Added SYNONYM CSN
2007-08-09 Deleted SYNONYM CSN
2007-08-09 Deleted SYNONYM COP9 complex
2007-06-27 Updated DEFINITION A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2007-06-14 Updated TERM signalosome
2005-08-04 Added SYNONYM CSN
2005-08-03 Updated DEFINITION A complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2005-08-02 Updated DEFINITION A complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2004-04-19 Added SYNONYM COP9 complex
2004-04-16 Deleted SYNONYM COP9 complex
2002-11-27 Updated DEFINITION A complex involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome; a distinguishing feature is its activity in deneddylation.
2002-05-24 Updated TERM signalosome complex
2002-02-06 Updated TERM signalosome
2001-08-06 Added DEFINITION A complex involved in regulation of development in many species; also regulates photomorphogenesis in plants; its subuits are related to those of the proteasome
2001-04-03 Updated TERM signalosome
2001-03-30 Added SYNONYM COP9 complex
2001-03-30 Added TERM signalosome

Term

Timestamp Action Category Detail
2013-07-22 Updated TERM COP9 signalosome
2007-06-14 Updated TERM signalosome
2002-05-24 Updated TERM signalosome complex
2002-02-06 Updated TERM signalosome
2001-04-03 Updated TERM signalosome
2001-03-30 Added TERM signalosome

Definition/synonyms

Timestamp Action Category Detail
2013-07-22 Deleted SYNONYM COP9 complex
2013-07-22 Added SYNONYM signalosome
2013-07-22 Added SYNONYM COP9 complex
2008-05-13 Added DEFINITION A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2008-05-12 Deleted DEFINITION A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2007-08-09 Added SYNONYM COP9 complex
2007-08-09 Added SYNONYM CSN
2007-08-09 Deleted SYNONYM CSN
2007-08-09 Deleted SYNONYM COP9 complex
2007-06-27 Updated DEFINITION A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2005-08-04 Added SYNONYM CSN
2005-08-03 Updated DEFINITION A complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2005-08-02 Updated DEFINITION A complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2004-04-19 Added SYNONYM COP9 complex
2004-04-16 Deleted SYNONYM COP9 complex
2002-11-27 Updated DEFINITION A complex involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome; a distinguishing feature is its activity in deneddylation.
2001-08-06 Added DEFINITION A complex involved in regulation of development in many species; also regulates photomorphogenesis in plants; its subuits are related to those of the proteasome
2001-03-30 Added SYNONYM COP9 complex

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044428 (nuclear part)
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