spacer

GO:0008113 peptide-methionine (S)-S-oxide reductase activity

Term Information

ID GO:0008113
Name peptide-methionine (S)-S-oxide reductase activity
Ontology Molecular Function
Definition Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
PMID:11169920
Secondary IDs GO:0033742 GO:0072561
GONUTS GO:0008113 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact protein-methionine-S-oxide reductase activity
exact peptide-methionine-(S)-S-oxide reductase activity
exact peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity
exact peptide methionine sulfoxide reductase activity
exact peptide Met(O) reductase activity
exact methionine sulphoxide reductase A activity
broad methionine sulfoxide reductase activity
exact methionine sulfoxide reductase A activity
exact methionine sulfoxide (protein) reductase activity
broad methionine S-oxide reductase activity
exact methionine S-oxide reductase (S-form oxidizing) activity
related MsrA

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.8.4.-
EC 1.8.4.11
InterPro IPR002569
MetaCyc RXN-8668
MetaCyc RXN-8669

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008113:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008113. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008113 based on the entire annotation set Co-occurrence statistics for GO:0008113 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-10-17 Added SECONDARY GO:0072561 (protein-methionine-S-oxide reductase activity)
2012-10-17 Added XREF EC:1.8.4.-
2012-10-17 Updated TERM peptide-methionine (S)-S-oxide reductase activity
2012-10-17 Deleted DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2012-10-17 Added DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
2012-10-17 Added SYNONYM protein-methionine-S-oxide reductase activity
2012-10-17 Added SYNONYM peptide-methionine-(S)-S-oxide reductase activity
2011-01-30 Deleted SYNONYM protein-methionine-S-oxide reductase activity
2010-09-03 Deleted DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2010-09-03 Added DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2009-05-21 Deleted XREF MetaCyc:PROTEIN-METHIONINE-S-OXIDE-REDUCTASE-RXN
2009-05-21 Added XREF MetaCyc:RXN-8669
2009-05-21 Added XREF MetaCyc:RXN-8668
2008-05-13 Added DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2008-05-12 Deleted DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2008-04-01 Updated RELATION is a GO:0016671 (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor)
2007-11-27 Updated DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2007-11-08 Updated TERM peptide-methionine-(S)-S-oxide reductase activity
2007-11-08 Deleted SYNONYM methionine sulfoxide (protein) reductase
2007-11-08 Deleted SYNONYM peptide methionine sulfoxide reductase
2007-11-08 Added SYNONYM MsrA
2007-11-08 Added SYNONYM methionine S-oxide reductase (S-form oxidizing) activity
2007-11-08 Added SYNONYM methionine S-oxide reductase activity
2007-11-08 Added SYNONYM methionine sulfoxide (protein) reductase activity
2007-11-08 Added SYNONYM methionine sulfoxide reductase A activity
2007-11-08 Added SYNONYM methionine sulfoxide reductase activity
2007-11-08 Added SYNONYM methionine sulphoxide reductase A activity
2007-11-08 Added SYNONYM peptide Met(O) reductase activity
2007-11-08 Added SYNONYM peptide methionine sulfoxide reductase activity
2007-11-08 Added SYNONYM peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity
2007-11-08 Added SYNONYM protein-methionine-S-oxide reductase activity
2007-11-08 Added XREF EC:1.8.4.11
2007-11-08 Deleted XREF EC:1.8.4.6
2007-08-09 Added SYNONYM methionine sulfoxide (protein) reductase
2007-08-09 Added SYNONYM peptide methionine sulfoxide reductase
2007-08-09 Deleted SYNONYM methionine sulfoxide (protein) reductase
2007-08-09 Deleted SYNONYM peptide methionine sulfoxide reductase
2006-02-04 Updated DEFINITION Catalysis of the reaction: protein L-methionine + thioredoxin disulfide = protein L-methionine S-oxide + thioredoxin.
2004-04-19 Added SYNONYM methionine sulfoxide (protein) reductase
2004-04-19 Added SYNONYM peptide methionine sulfoxide reductase
2004-04-16 Deleted SYNONYM methionine sulfoxide (protein) reductase
2004-04-16 Deleted SYNONYM peptide methionine sulfoxide reductase
2003-10-27 Added SYNONYM methionine sulfoxide (protein) reductase
2003-10-27 Added SYNONYM peptide methionine sulfoxide reductase
2003-10-27 Added XREF MetaCyc:PROTEIN-METHIONINE-S-OXIDE-REDUCTASE-RXN
2003-08-21 Deleted SYNONYM methionine sulfoxide (protein) reductase
2003-08-21 Deleted SYNONYM peptide methionine sulfoxide reductase
2003-03-19 Updated TERM protein-methionine-S-oxide reductase activity
2003-03-19 Deleted SYNONYM (protein) methionine-S-sulfoxide reductase
2003-03-19 Deleted SYNONYM methionine-S-sulfoxide reductase
2002-11-27 Added DEFINITION Catalysis of the reaction: protein L-methionine + oxidized thioredoxin = protein L-methionine S-oxide + reduced thioredoxin.
2002-11-08 Added SYNONYM methionine sulfoxide (protein) reductase
2002-04-08 Added SYNONYM peptide methionine sulfoxide reductase
2002-04-08 Added SYNONYM methionine-S-sulfoxide reductase
2002-04-08 Added SYNONYM (protein) methionine-S-sulfoxide reductase
2002-02-06 Updated TERM protein-methionine-S-oxide reductase
2001-04-03 Updated TERM protein-methionine-S-oxide reductase
2001-03-30 Added XREF EC:1.8.4.6
2001-03-30 Added TERM protein-methionine-S-oxide reductase

Term

Timestamp Action Category Detail
2012-10-17 Updated TERM peptide-methionine (S)-S-oxide reductase activity
2007-11-08 Updated TERM peptide-methionine-(S)-S-oxide reductase activity
2003-03-19 Updated TERM protein-methionine-S-oxide reductase activity
2002-02-06 Updated TERM protein-methionine-S-oxide reductase
2001-04-03 Updated TERM protein-methionine-S-oxide reductase
2001-03-30 Added TERM protein-methionine-S-oxide reductase

Definition/synonyms

Timestamp Action Category Detail
2012-10-17 Deleted DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2012-10-17 Added DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
2012-10-17 Added SYNONYM protein-methionine-S-oxide reductase activity
2012-10-17 Added SYNONYM peptide-methionine-(S)-S-oxide reductase activity
2011-01-30 Deleted SYNONYM protein-methionine-S-oxide reductase activity
2010-09-03 Deleted DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2010-09-03 Added DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2008-05-13 Added DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2008-05-12 Deleted DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2007-11-27 Updated DEFINITION Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
2007-11-08 Deleted SYNONYM methionine sulfoxide (protein) reductase
2007-11-08 Deleted SYNONYM peptide methionine sulfoxide reductase
2007-11-08 Added SYNONYM MsrA
2007-11-08 Added SYNONYM methionine S-oxide reductase (S-form oxidizing) activity
2007-11-08 Added SYNONYM methionine S-oxide reductase activity
2007-11-08 Added SYNONYM methionine sulfoxide (protein) reductase activity
2007-11-08 Added SYNONYM methionine sulfoxide reductase A activity
2007-11-08 Added SYNONYM methionine sulfoxide reductase activity
2007-11-08 Added SYNONYM methionine sulphoxide reductase A activity
2007-11-08 Added SYNONYM peptide Met(O) reductase activity
2007-11-08 Added SYNONYM peptide methionine sulfoxide reductase activity
2007-11-08 Added SYNONYM peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity
2007-11-08 Added SYNONYM protein-methionine-S-oxide reductase activity
2007-08-09 Added SYNONYM methionine sulfoxide (protein) reductase
2007-08-09 Added SYNONYM peptide methionine sulfoxide reductase
2007-08-09 Deleted SYNONYM methionine sulfoxide (protein) reductase
2007-08-09 Deleted SYNONYM peptide methionine sulfoxide reductase
2006-02-04 Updated DEFINITION Catalysis of the reaction: protein L-methionine + thioredoxin disulfide = protein L-methionine S-oxide + thioredoxin.
2004-04-19 Added SYNONYM methionine sulfoxide (protein) reductase
2004-04-19 Added SYNONYM peptide methionine sulfoxide reductase
2004-04-16 Deleted SYNONYM methionine sulfoxide (protein) reductase
2004-04-16 Deleted SYNONYM peptide methionine sulfoxide reductase
2003-10-27 Added SYNONYM methionine sulfoxide (protein) reductase
2003-10-27 Added SYNONYM peptide methionine sulfoxide reductase
2003-08-21 Deleted SYNONYM methionine sulfoxide (protein) reductase
2003-08-21 Deleted SYNONYM peptide methionine sulfoxide reductase
2003-03-19 Deleted SYNONYM (protein) methionine-S-sulfoxide reductase
2003-03-19 Deleted SYNONYM methionine-S-sulfoxide reductase
2002-11-27 Added DEFINITION Catalysis of the reaction: protein L-methionine + oxidized thioredoxin = protein L-methionine S-oxide + reduced thioredoxin.
2002-11-08 Added SYNONYM methionine sulfoxide (protein) reductase
2002-04-08 Added SYNONYM peptide methionine sulfoxide reductase
2002-04-08 Added SYNONYM methionine-S-sulfoxide reductase
2002-04-08 Added SYNONYM (protein) methionine-S-sulfoxide reductase

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016671 (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor)

Cross-references

Timestamp Action Category Detail
2012-10-17 Added XREF EC:1.8.4.-
2009-05-21 Deleted XREF MetaCyc:PROTEIN-METHIONINE-S-OXIDE-REDUCTASE-RXN
2009-05-21 Added XREF MetaCyc:RXN-8669
2009-05-21 Added XREF MetaCyc:RXN-8668
2007-11-08 Added XREF EC:1.8.4.11
2007-11-08 Deleted XREF EC:1.8.4.6
2003-10-27 Added XREF MetaCyc:PROTEIN-METHIONINE-S-OXIDE-REDUCTASE-RXN
2001-03-30 Added XREF EC:1.8.4.6

Other

Timestamp Action Category Detail
2012-10-17 Added SECONDARY GO:0072561 (protein-methionine-S-oxide reductase activity)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
15ms