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GO:0008009 chemokine activity

Term Information

ID GO:0008009
Name chemokine activity
Ontology Molecular Function
Definition The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
PMID:12183377
Comment See also the molecular function term 'cytokine activity ; GO:0005125'.
GONUTS GO:0008009 Wiki Page
Acknowledgements This term was created by the GO Consortium with support from BHF logo

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Binding term considerationsLink

Cross-references

Database ID
InterPro IPR000827
InterPro IPR001089
InterPro IPR001811
InterPro IPR008097
InterPro IPR008105
InterPro IPR018048
InterPro IPR026296
InterPro IPR027220
InterPro IPR027221
InterPro IPR027222
InterPro IPR027223
InterPro IPR027225
InterPro IPR028469

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008009:
Relationship To GO:0008009 Child Term Child Term Name
Regulates GO:1900136 regulation of chemokine activity
Negatively regulates GO:1900137 negative regulation of chemokine activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008009. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008009 based on the entire annotation set Co-occurrence statistics for GO:0008009 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-01-18 Deleted DEFINITION The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2014-01-18 Added DEFINITION The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
2014-01-15 Added RELATION part of GO:0060326 (cell chemotaxis)
2008-05-13 Added DEFINITION The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2008-05-12 Deleted DEFINITION The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2008-04-01 Updated RELATION is a GO:0005125 (cytokine activity)
2008-04-01 Updated RELATION is a GO:0042379 (chemokine receptor binding)
2004-07-22 Updated DEFINITION The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2003-03-26 Updated DEFINITION The function of a family of chemotactic pro-inflammatory activation-inducible cytokines (GO:0005125) acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2003-03-19 Updated TERM chemokine activity
2002-11-27 Updated DEFINITION The function of a family of pro-inflammatory activation-inducible cytokines (GO:0005125) that are mainly chemotactic for different cell types; have molecular masses of 8-10 kDa; share common tertiary structures; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2002-02-06 Updated TERM chemokine
2001-08-06 Added DEFINITION The function of a family of pro-inflammatory activation-inducible cytokines (GO:0005125) that are mainly chemotactic for different cell types; have molecular masses of 8-10 kDa; share common tertiary structures; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2001-04-03 Updated TERM chemokine
2001-03-30 Added TERM chemokine

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM chemokine activity
2002-02-06 Updated TERM chemokine
2001-04-03 Updated TERM chemokine
2001-03-30 Added TERM chemokine

Definition/synonyms

Timestamp Action Category Detail
2014-01-18 Deleted DEFINITION The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2014-01-18 Added DEFINITION The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
2008-05-13 Added DEFINITION The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2008-05-12 Deleted DEFINITION The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2004-07-22 Updated DEFINITION The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2003-03-26 Updated DEFINITION The function of a family of chemotactic pro-inflammatory activation-inducible cytokines (GO:0005125) acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2002-11-27 Updated DEFINITION The function of a family of pro-inflammatory activation-inducible cytokines (GO:0005125) that are mainly chemotactic for different cell types; have molecular masses of 8-10 kDa; share common tertiary structures; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
2001-08-06 Added DEFINITION The function of a family of pro-inflammatory activation-inducible cytokines (GO:0005125) that are mainly chemotactic for different cell types; have molecular masses of 8-10 kDa; share common tertiary structures; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.

Relationships

Timestamp Action Category Detail
2014-01-15 Added RELATION part of GO:0060326 (cell chemotaxis)
2008-04-01 Updated RELATION is a GO:0005125 (cytokine activity)
2008-04-01 Updated RELATION is a GO:0042379 (chemokine receptor binding)
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