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GO:0007597 blood coagulation, intrinsic pathway

Term Information

ID GO:0007597
Name blood coagulation, intrinsic pathway
Ontology Biological Process
Definition A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.
Comment See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'.
GONUTS GO:0007597 Wiki Page

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000299 GO:0032501 multicellular organismal process only_in_taxon 2759 Eukaryota
GOTAX:0000537 GO:0032501 multicellular organismal process never_in_taxon 4932 Saccharomyces cerevisiae
GOTAX:0000538 GO:0032501 multicellular organismal process never_in_taxon 4896 Schizosaccharomyces pombe
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007597:
Relationship To GO:0007597 Child Term Child Term Name
Negatively regulates GO:2000267 negative regulation of blood coagulation, intrinsic pathway
Regulates GO:2000266 regulation of blood coagulation, intrinsic pathway
Positively regulates GO:2000268 positive regulation of blood coagulation, intrinsic pathway

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007597. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007597 based on the entire annotation set Co-occurrence statistics for GO:0007597 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-11-24 Added RELATION part of GO:0072378 (blood coagulation, fibrin clot formation)
2010-11-24 Added RELATION is a GO:0072376 (protein activation cascade)
2010-11-24 Deleted RELATION is a GO:0007596 (blood coagulation)
2010-11-24 Added DEFINITION A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.
2010-11-24 Deleted DEFINITION A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid.
2008-05-13 Added DEFINITION A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid.
2008-05-12 Deleted DEFINITION A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid.
2008-04-01 Updated RELATION is a GO:0007596 (blood coagulation)
2002-11-27 Added DEFINITION A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid.
2002-02-06 Updated TERM blood coagulation, intrinsic pathway
2001-04-03 Updated TERM blood coagulation, intrinsic pathway
2001-03-30 Added TERM blood coagulation, intrinsic pathway

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM blood coagulation, intrinsic pathway
2001-04-03 Updated TERM blood coagulation, intrinsic pathway
2001-03-30 Added TERM blood coagulation, intrinsic pathway

Definition/synonyms

Timestamp Action Category Detail
2010-11-24 Added DEFINITION A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.
2010-11-24 Deleted DEFINITION A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid.
2008-05-13 Added DEFINITION A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid.
2008-05-12 Deleted DEFINITION A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid.
2002-11-27 Added DEFINITION A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid.

Relationships

Timestamp Action Category Detail
2010-11-24 Added RELATION part of GO:0072378 (blood coagulation, fibrin clot formation)
2010-11-24 Added RELATION is a GO:0072376 (protein activation cascade)
2010-11-24 Deleted RELATION is a GO:0007596 (blood coagulation)
2008-04-01 Updated RELATION is a GO:0007596 (blood coagulation)
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