spacer

GO:0007268 chemical synaptic transmission

Term Information

ID GO:0007268
Name chemical synaptic transmission
Ontology Biological Process
Definition The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
GONUTS GO:0007268 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related neurotransmission
broad signal transmission across a synapse
broad synaptic transmission

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0099536 synaptic signaling never_in_taxon 4895 Schizosaccharomyces
More information on taxon constraints in GO is available here

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_synapse315

Cross-references

Database ID
InterPro IPR000505
InterPro IPR001069
InterPro IPR001520
InterPro IPR002147
InterPro IPR002367
InterPro IPR005456
InterPro IPR019568
InterPro IPR027080
InterPro IPR027087
InterPro IPR027158
InterPro IPR027160
InterPro IPR027425
InterPro IPR028390
InterPro IPR030358
InterPro IPR030524
InterPro IPR030528
InterPro IPR030529
InterPro IPR030530
InterPro IPR030535
InterPro IPR033545
UniProtKB-KW Neurotransmitter
Wikipedia Neurotransmission

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0007273 obsolete regulation of synapse CONSIDER GO:0007268

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007268:
Relationship To GO:0007268 Child Term Child Term Name
Is a GO:0007270 neuron-neuron synaptic transmission
Is a GO:0007274 neuromuscular synaptic transmission
Part of GO:0090507 phenylethylamine metabolic process involved in synaptic transmission
Is a GO:0007271 synaptic transmission, cholinergic
Is a GO:0090127 positive regulation of synapse maturation by synaptic transmission
Regulates GO:0050804 modulation of synaptic transmission
Negatively regulates GO:0050805 negative regulation of synaptic transmission
Positively regulates GO:0050806 positive regulation of synaptic transmission
Part of GO:0090508 phenylethylamine biosynthetic process involved in synaptic transmission
Part of GO:0007269 neurotransmitter secretion
Regulates GO:0099083 retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
Is a GO:0098814 spontaneous synaptic transmission
Is a GO:0098976 excitatory chemical synaptic transmission
Is a GO:0098977 inhibitory chemical synaptic transmission
Regulates GO:0098987 regulation of modification of synapse structure, modulating synaptic transmission
Regulates GO:0098925 retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Part of GO:0099531 presynaptic process involved in chemical synaptic transmission
Regulates GO:0099546 protein catabolic process, modulating synaptic transmission
Regulates GO:0099547 regulation of translation at synapse, modulating synaptic transmission
Regulates GO:0099550 trans-synaptic signaling, modulating synaptic transmission
Regulates GO:0099551 trans-synaptic signaling by neuropeptide, modulating synaptic transmission
Regulates GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission
Regulates GO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Regulates GO:0099555 trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Regulates GO:0099556 trans-synaptic signaling by carbon monoxide, modulating synaptic transmission
Regulates GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
Part of GO:0099565 chemical synaptic transmission, postsynaptic
Regulates GO:0099574 regulation of protein catabolic process at synapse, modulating synaptic transmission
Regulates GO:0099575 regulation of protein catabolic process at presynapse, modulating synaptic transmission
Regulates GO:0099576 regulation of protein catabolic process at postsynapse, modulating synaptic transmission
Regulates GO:0099577 regulation of translation at presynapse, modulating synaptic transmission
Regulates GO:0099578 regulation of translation at postsynapse, modulating synaptic transmission
Part of GO:0098960 postsynaptic neurotransmitter receptor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007268. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007268 based on the entire annotation set Co-occurrence statistics for GO:0007268 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-06-03 Updated TERM chemical synaptic transmission
2016-04-28 Deleted RELATION is a GO:0099537 (trans-synaptic signaling)
2016-04-28 Added RELATION is a GO:0098916 (anterograde trans-synaptic signaling)
2016-02-04 Added RELATION has part GO:0019226 (transmission of nerve impulse)
2016-01-20 Added RELATION is a GO:0099537 (trans-synaptic signaling)
2016-01-20 Deleted RELATION is a GO:0007267 (cell-cell signaling)
2016-01-20 Deleted SYNONYM regulation of synapse
2016-01-20 Deleted SYNONYM signal transmission across a synapse
2016-01-20 Added SYNONYM signal transmission across a synapse
2016-01-20 Added SYNONYM synaptic transmission
2016-01-20 Deleted DEFINITION The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
2016-01-20 Added DEFINITION The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2015-06-25 Deleted RELATION is a GO:0023052 (signaling)
2014-12-13 Added SLIM goslim_synapse
2014-06-05 Added RELATION is a GO:0023052 (signaling)
2014-01-29 Deleted RELATION part of GO:0019226 (transmission of nerve impulse)
2010-02-20 Added SYNONYM signal transmission across a synapse
2009-03-02 Added XREF Wikipedia:Neurotransmission
2008-05-13 Added DEFINITION The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
2008-05-12 Deleted DEFINITION The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
2008-04-01 Updated RELATION is a GO:0007267 (cell-cell signaling)
2008-04-01 Updated RELATION part of GO:0019226 (transmission of nerve impulse)
2007-08-09 Added SYNONYM neurotransmission
2007-08-09 Added SYNONYM regulation of synapse
2007-08-09 Deleted SYNONYM neurotransmission
2007-08-09 Deleted SYNONYM regulation of synapse
2007-04-07 Added SYNONYM neurotransmission
2005-08-10 Added SYNONYM regulation of synapse
2002-11-27 Added DEFINITION The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
2002-02-06 Updated TERM synaptic transmission
2001-04-03 Updated TERM synaptic transmission
2001-03-30 Added TERM synaptic transmission

Term

Timestamp Action Category Detail
2016-06-03 Updated TERM chemical synaptic transmission
2002-02-06 Updated TERM synaptic transmission
2001-04-03 Updated TERM synaptic transmission
2001-03-30 Added TERM synaptic transmission

Definition/synonyms

Timestamp Action Category Detail
2016-01-20 Deleted SYNONYM regulation of synapse
2016-01-20 Deleted SYNONYM signal transmission across a synapse
2016-01-20 Added SYNONYM signal transmission across a synapse
2016-01-20 Added SYNONYM synaptic transmission
2016-01-20 Deleted DEFINITION The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
2016-01-20 Added DEFINITION The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2010-02-20 Added SYNONYM signal transmission across a synapse
2008-05-13 Added DEFINITION The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
2008-05-12 Deleted DEFINITION The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
2007-08-09 Added SYNONYM neurotransmission
2007-08-09 Added SYNONYM regulation of synapse
2007-08-09 Deleted SYNONYM neurotransmission
2007-08-09 Deleted SYNONYM regulation of synapse
2007-04-07 Added SYNONYM neurotransmission
2005-08-10 Added SYNONYM regulation of synapse
2002-11-27 Added DEFINITION The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

Relationships

Timestamp Action Category Detail
2016-04-28 Deleted RELATION is a GO:0099537 (trans-synaptic signaling)
2016-04-28 Added RELATION is a GO:0098916 (anterograde trans-synaptic signaling)
2016-02-04 Added RELATION has part GO:0019226 (transmission of nerve impulse)
2016-01-20 Added RELATION is a GO:0099537 (trans-synaptic signaling)
2016-01-20 Deleted RELATION is a GO:0007267 (cell-cell signaling)
2015-06-25 Deleted RELATION is a GO:0023052 (signaling)
2014-06-05 Added RELATION is a GO:0023052 (signaling)
2014-01-29 Deleted RELATION part of GO:0019226 (transmission of nerve impulse)
2008-04-01 Updated RELATION is a GO:0007267 (cell-cell signaling)
2008-04-01 Updated RELATION part of GO:0019226 (transmission of nerve impulse)

Cross-references

Timestamp Action Category Detail
2009-03-02 Added XREF Wikipedia:Neurotransmission

Other

Timestamp Action Category Detail
2014-12-13 Added SLIM goslim_synapse
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
17ms