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GO:0007254 JNK cascade

Term Information

ID GO:0007254
Name JNK cascade
Ontology Biological Process
Definition An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
PMID:11790549 PMID:20811974
GONUTS GO:0007254 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact c-Jun N-terminal kinase cascade
narrow MAPK8 cascade
narrow MAPK10 cascade
narrow JNK3 cascade
narrow JNK2 cascade
broad stress-activated protein kinase cascade
broad SAPK cascade
narrow MAPK9 cascade
narrow JNK1 cascade

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0000165 MAPK cascade only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR027257
InterPro IPR027258

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0016910 obsolete SAP kinase 3 activity CONSIDER GO:0007254
GO:0016911 obsolete SAP kinase 4 activity CONSIDER GO:0007254
GO:0016912 obsolete SAP kinase 5 activity CONSIDER GO:0007254

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007254:
Relationship To GO:0007254 Child Term Child Term Name
Part of GO:0007256 activation of JNKK activity
Part of GO:0007257 activation of JUN kinase activity
Part of GO:0007258 JUN phosphorylation
Part of GO:0042655 activation of JNKKK activity
Regulates GO:0046328 regulation of JNK cascade
Negatively regulates GO:0046329 negative regulation of JNK cascade
Positively regulates GO:0046330 positive regulation of JNK cascade

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007254. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007254 based on the entire annotation set Co-occurrence statistics for GO:0007254 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-27 Added SYNONYM c-Jun N-terminal kinase cascade
2012-01-27 Deleted DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2012-01-27 Added DEFINITION An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
2012-01-18 Added RELATION is a GO:0051403 (stress-activated MAPK cascade)
2012-01-18 Deleted RELATION is a GO:0000165 (MAPK cascade)
2012-01-18 Deleted RELATION is a GO:0031098 (stress-activated protein kinase signaling cascade)
2011-09-11 Added RELATION has part GO:0038031 (non-canonical Wnt signaling pathway via JNK cascade)
2009-02-21 Added SYNONYM JNK1 cascade
2009-02-21 Added SYNONYM JNK2 cascade
2009-02-21 Added SYNONYM JNK3 cascade
2009-02-21 Added SYNONYM MAPK10 cascade
2009-02-21 Added SYNONYM MAPK8 cascade
2009-02-21 Added SYNONYM MAPK9 cascade
2008-05-13 Added DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2008-05-12 Deleted DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2008-04-01 Updated RELATION is a GO:0031098 (stress-activated protein kinase signaling cascade)
2008-04-01 Updated RELATION is a GO:0000165 (MAPK cascade)
2007-10-05 Deleted SYNONYM SAP kinase 3 activity
2007-10-05 Deleted SYNONYM SAP kinase 4 activity
2007-10-05 Deleted SYNONYM SAP kinase 5 activity
2007-08-09 Added SYNONYM SAP kinase 3 activity
2007-08-09 Added SYNONYM SAP kinase 4 activity
2007-08-09 Added SYNONYM SAP kinase 5 activity
2007-08-09 Added SYNONYM SAPK cascade
2007-08-09 Added SYNONYM stress-activated protein kinase cascade
2007-08-09 Deleted SYNONYM SAP kinase 3 activity
2007-08-09 Deleted SYNONYM SAP kinase 4 activity
2007-08-09 Deleted SYNONYM SAP kinase 5 activity
2007-08-09 Deleted SYNONYM SAPK cascade
2007-08-09 Deleted SYNONYM stress-activated protein kinase cascade
2005-08-10 Added SYNONYM SAP kinase 3 activity
2005-08-10 Added SYNONYM SAP kinase 4 activity
2005-08-10 Added SYNONYM SAP kinase 5 activity
2005-01-20 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-19 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-17 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-16 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-15 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-14 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-13 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-12 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-11 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-08 Added SYNONYM stress-activated protein kinase cascade
2005-01-08 Added SYNONYM SAPK cascade
2003-04-24 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2003-04-15 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a sub-family of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2003-04-12 Added DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a sub-family of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2002-02-06 Updated TERM JNK cascade
2001-04-03 Updated TERM JNK cascade
2001-03-30 Added TERM JNK cascade

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM JNK cascade
2001-04-03 Updated TERM JNK cascade
2001-03-30 Added TERM JNK cascade

Definition/synonyms

Timestamp Action Category Detail
2012-01-27 Added SYNONYM c-Jun N-terminal kinase cascade
2012-01-27 Deleted DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2012-01-27 Added DEFINITION An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
2009-02-21 Added SYNONYM JNK1 cascade
2009-02-21 Added SYNONYM JNK2 cascade
2009-02-21 Added SYNONYM JNK3 cascade
2009-02-21 Added SYNONYM MAPK10 cascade
2009-02-21 Added SYNONYM MAPK8 cascade
2009-02-21 Added SYNONYM MAPK9 cascade
2008-05-13 Added DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2008-05-12 Deleted DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2007-10-05 Deleted SYNONYM SAP kinase 3 activity
2007-10-05 Deleted SYNONYM SAP kinase 4 activity
2007-10-05 Deleted SYNONYM SAP kinase 5 activity
2007-08-09 Added SYNONYM SAP kinase 3 activity
2007-08-09 Added SYNONYM SAP kinase 4 activity
2007-08-09 Added SYNONYM SAP kinase 5 activity
2007-08-09 Added SYNONYM SAPK cascade
2007-08-09 Added SYNONYM stress-activated protein kinase cascade
2007-08-09 Deleted SYNONYM SAP kinase 3 activity
2007-08-09 Deleted SYNONYM SAP kinase 4 activity
2007-08-09 Deleted SYNONYM SAP kinase 5 activity
2007-08-09 Deleted SYNONYM SAPK cascade
2007-08-09 Deleted SYNONYM stress-activated protein kinase cascade
2005-08-10 Added SYNONYM SAP kinase 3 activity
2005-08-10 Added SYNONYM SAP kinase 4 activity
2005-08-10 Added SYNONYM SAP kinase 5 activity
2005-01-20 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-19 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-17 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-16 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-15 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-14 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-13 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-12 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-11 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2005-01-08 Added SYNONYM stress-activated protein kinase cascade
2005-01-08 Added SYNONYM SAPK cascade
2003-04-24 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2003-04-15 Updated DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a sub-family of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
2003-04-12 Added DEFINITION A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a sub-family of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.

Relationships

Timestamp Action Category Detail
2012-01-18 Added RELATION is a GO:0051403 (stress-activated MAPK cascade)
2012-01-18 Deleted RELATION is a GO:0000165 (MAPK cascade)
2012-01-18 Deleted RELATION is a GO:0031098 (stress-activated protein kinase signaling cascade)
2011-09-11 Added RELATION has part GO:0038031 (non-canonical Wnt signaling pathway via JNK cascade)
2008-04-01 Updated RELATION is a GO:0031098 (stress-activated protein kinase signaling cascade)
2008-04-01 Updated RELATION is a GO:0000165 (MAPK cascade)
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