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GO:0007254 JNK cascade

A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.

Term Information

ID GO:0007254
Name JNK cascade
Ontology Biological Process
Definition A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.
Comment

Synonyms

Type Synonym
broad SAPK cascade
broad stress-activated protein kinase cascade
narrow MAPK10 cascade
narrow JNK3 cascade
narrow JNK2 cascade
narrow JNK1 cascade
narrow MAPK9 cascade
narrow MAPK8 cascade

This term can be used instead of these obsolete terms:

GO:0016911 SAP kinase 4 activity (consider GO:0007254)
GO:0016912 SAP kinase 5 activity (consider GO:0007254)
GO:0016910 SAP kinase 3 activity (consider GO:0007254)

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Ancestor Chart

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0065007 biological regulation
GO:0050896 response to stimulus
GO:0050789 regulation of biological process
GO:0007154 cell communication
GO:0006950 response to stress
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0033554 cellular response to stress
GO:0007165 signal transduction
GO:0007242 intracellular signaling cascade
GO:0007243 protein kinase cascade
GO:0000165 MAPKKK cascade
GO:0031098 stress-activated protein kinase signaling pathway
GO:0007254 JNK cascade

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
P GO:0042655 activation of JNKKK activity
P GO:0007256 activation of JNKK activity
P GO:0007257 activation of JUN kinase activity
P GO:0007258 JUN phosphorylation
R GO:0046328 regulation of JNK cascade
NR GO:0046329 negative regulation of JNK cascade
PR GO:0046330 positive regulation of JNK cascade

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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