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GO:0007252 I-kappaB phosphorylation

Term Information

ID GO:0007252
Name I-kappaB phosphorylation
Ontology Biological Process
Definition The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
PMID:21772278 PMID:7594468
GONUTS GO:0007252 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact inhibitor of NF-kappaB phosphorylation
exact IKB phosphorylation
exact IkappaB phosphorylation
exact inhibitor of kappaB phosphorylation

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Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007252:
Relationship To GO:0007252 Child Term Child Term Name
Part of GO:0008384 IkappaB kinase activity

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007252. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007252 based on the entire annotation set Co-occurrence statistics for GO:0007252 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-11 Added DEFINITION The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-11 Deleted DEFINITION The process of introducing a phosphate group into an I-kappaB protein.
2012-01-11 Added SYNONYM IkappaB phosphorylation
2012-01-11 Added SYNONYM IKB phosphorylation
2012-01-11 Added SYNONYM inhibitor of NF-kappaB phosphorylation
2012-01-11 Added SYNONYM inhibitor of kappaB phosphorylation
2008-05-13 Added DEFINITION The process of introducing a phosphate group into an I-kappaB protein.
2008-05-12 Deleted DEFINITION The process of introducing a phosphate group into an I-kappaB protein.
2008-04-01 Updated RELATION is a GO:0006468 (protein phosphorylation)
2008-04-01 Updated RELATION part of GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
2007-10-25 Updated DEFINITION The process of introducing a phosphate group into an I-kappaB protein.
2002-11-27 Added DEFINITION The process of introducing a phosphoric group into an I-kappaB protein.
2002-08-31 Updated TERM I-kappaB phosphorylation
2002-02-06 Updated TERM phosphorylation of I-kappaB
2001-04-03 Updated TERM phosphorylation of I-kappaB
2001-03-30 Added TERM phosphorylation of I-kappaB

Term

Timestamp Action Category Detail
2002-08-31 Updated TERM I-kappaB phosphorylation
2002-02-06 Updated TERM phosphorylation of I-kappaB
2001-04-03 Updated TERM phosphorylation of I-kappaB
2001-03-30 Added TERM phosphorylation of I-kappaB

Definition/synonyms

Timestamp Action Category Detail
2012-01-11 Added DEFINITION The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-11 Deleted DEFINITION The process of introducing a phosphate group into an I-kappaB protein.
2012-01-11 Added SYNONYM IkappaB phosphorylation
2012-01-11 Added SYNONYM IKB phosphorylation
2012-01-11 Added SYNONYM inhibitor of NF-kappaB phosphorylation
2012-01-11 Added SYNONYM inhibitor of kappaB phosphorylation
2008-05-13 Added DEFINITION The process of introducing a phosphate group into an I-kappaB protein.
2008-05-12 Deleted DEFINITION The process of introducing a phosphate group into an I-kappaB protein.
2007-10-25 Updated DEFINITION The process of introducing a phosphate group into an I-kappaB protein.
2002-11-27 Added DEFINITION The process of introducing a phosphoric group into an I-kappaB protein.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0006468 (protein phosphorylation)
2008-04-01 Updated RELATION part of GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
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