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GO:0007249 I-kappaB kinase/NF-kappaB signaling

Term Information

ID GO:0007249
Name I-kappaB kinase/NF-kappaB signaling
Ontology Biological Process
Definition The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
PMID:12773372
GONUTS GO:0007249 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact canonical NF-kappaB signaling cascade
related activation of the inhibitor of kappa kinase
exact I-kappaB kinase/NF-kappaB signal transduction
related p50-dependent NF-kappaB signaling
related I-kappaB kinase/NF-kappaB cascade
broad NF-kappaB cascade

GO Discussions

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Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR030312

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0007251 activation of the inhibitor of kappa kinase CONSIDER GO:0007249

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007249:
Relationship To GO:0007249 Child Term Child Term Name
Part of GO:0007252 I-kappaB phosphorylation
Part of GO:0008588 release of cytoplasmic sequestered NF-kappaB
Regulates GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
Positively regulates GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Negatively regulates GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
Part of GO:0042348 NF-kappaB import into nucleus
Has part GO:0051092 positive regulation of NF-kappaB transcription factor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007249. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007249 based on the entire annotation set Co-occurrence statistics for GO:0007249 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-14 Added SYNONYM I-kappaB kinase/NF-kappaB signal transduction
2013-12-04 Added RELATION is a GO:0035556 (intracellular signal transduction)
2013-12-04 Deleted RELATION is a GO:0007243 (intracellular protein kinase cascade)
2013-12-04 Added SYNONYM I-kappaB kinase/NF-kappaB cascade
2013-12-04 Updated TERM I-kappaB kinase/NF-kappaB signaling
2012-05-17 Added RELATION has part GO:0038168 (epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade)
2012-01-18 Added DEFINITION The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-18 Deleted DEFINITION The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of IKK and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-11 Deleted DEFINITION A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.
2012-01-11 Added DEFINITION The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of IKK and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-11 Added SYNONYM p50-dependent NF-kappaB signaling
2012-01-11 Added SYNONYM NF-kappaB cascade
2012-01-11 Added SYNONYM canonical NF-kappaB signaling cascade
2012-01-11 Deleted SYNONYM NIK-I-kappaB/NF-kappaB cascade
2012-01-11 Deleted SYNONYM NF-kappaB cascade
2010-08-03 Added SYNONYM NF-kappaB cascade
2008-05-13 Added DEFINITION A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.
2008-05-12 Deleted DEFINITION A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.
2008-04-01 Updated RELATION is a GO:0007243 (intracellular protein kinase cascade)
2007-08-09 Added SYNONYM NIK-I-kappaB/NF-kappaB cascade
2007-08-09 Added SYNONYM activation of the inhibitor of kappa kinase
2007-08-09 Deleted SYNONYM NIK-I-kappaB/NF-kappaB cascade
2007-08-09 Deleted SYNONYM activation of the inhibitor of kappa kinase
2005-12-15 Added SYNONYM NIK-I-kappaB/NF-kappaB cascade
2005-08-10 Added SYNONYM activation of the inhibitor of kappa kinase
2004-03-07 Updated TERM I-kappaB kinase/NF-kappaB cascade
2004-03-06 Added DEFINITION A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.
2002-02-06 Updated TERM NIK-I-kappaB/NF-kappaB cascade
2001-04-03 Updated TERM NIK-I-kappaB/NF-kappaB cascade
2001-03-30 Added TERM NIK-I-kappaB/NF-kappaB cascade

Term

Timestamp Action Category Detail
2013-12-04 Updated TERM I-kappaB kinase/NF-kappaB signaling
2004-03-07 Updated TERM I-kappaB kinase/NF-kappaB cascade
2002-02-06 Updated TERM NIK-I-kappaB/NF-kappaB cascade
2001-04-03 Updated TERM NIK-I-kappaB/NF-kappaB cascade
2001-03-30 Added TERM NIK-I-kappaB/NF-kappaB cascade

Definition/synonyms

Timestamp Action Category Detail
2013-12-14 Added SYNONYM I-kappaB kinase/NF-kappaB signal transduction
2013-12-04 Added SYNONYM I-kappaB kinase/NF-kappaB cascade
2012-01-18 Added DEFINITION The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-18 Deleted DEFINITION The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of IKK and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-11 Deleted DEFINITION A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.
2012-01-11 Added DEFINITION The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of IKK and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2012-01-11 Added SYNONYM p50-dependent NF-kappaB signaling
2012-01-11 Added SYNONYM NF-kappaB cascade
2012-01-11 Added SYNONYM canonical NF-kappaB signaling cascade
2012-01-11 Deleted SYNONYM NIK-I-kappaB/NF-kappaB cascade
2012-01-11 Deleted SYNONYM NF-kappaB cascade
2010-08-03 Added SYNONYM NF-kappaB cascade
2008-05-13 Added DEFINITION A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.
2008-05-12 Deleted DEFINITION A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.
2007-08-09 Added SYNONYM NIK-I-kappaB/NF-kappaB cascade
2007-08-09 Added SYNONYM activation of the inhibitor of kappa kinase
2007-08-09 Deleted SYNONYM NIK-I-kappaB/NF-kappaB cascade
2007-08-09 Deleted SYNONYM activation of the inhibitor of kappa kinase
2005-12-15 Added SYNONYM NIK-I-kappaB/NF-kappaB cascade
2005-08-10 Added SYNONYM activation of the inhibitor of kappa kinase
2004-03-06 Added DEFINITION A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.

Relationships

Timestamp Action Category Detail
2013-12-04 Added RELATION is a GO:0035556 (intracellular signal transduction)
2013-12-04 Deleted RELATION is a GO:0007243 (intracellular protein kinase cascade)
2012-05-17 Added RELATION has part GO:0038168 (epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade)
2008-04-01 Updated RELATION is a GO:0007243 (intracellular protein kinase cascade)
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