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GO:0035556 intracellular signal transduction

Term Information

ID GO:0035556
Name intracellular signal transduction
Ontology Biological Process
Definition The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
Secondary IDs GO:0007242 GO:0007243 GO:0023013 GO:0023034
GONUTS GO:0035556 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related signal transduction via intracellular signaling cascade
related intracellular signaling pathway
exact intracellular signaling chain
narrow intracellular protein kinase cascade
related intracellular signaling cascade
narrow protein kinase cascade
narrow signal transmission via intracellular cascade
narrow intracellular signal transduction pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR000591
InterPro IPR001054
InterPro IPR001192
InterPro IPR001331
InterPro IPR001493
InterPro IPR001496
InterPro IPR001562
InterPro IPR001711
InterPro IPR002031
InterPro IPR002219
InterPro IPR003377
InterPro IPR003533
InterPro IPR006019
InterPro IPR012234
InterPro IPR015012
InterPro IPR016239
InterPro IPR016251
InterPro IPR017090
InterPro IPR018297
InterPro IPR020693
InterPro IPR020775
InterPro IPR020776
InterPro IPR028273
InterPro IPR028382
InterPro IPR028413
InterPro IPR028557
InterPro IPR028558
InterPro IPR028749
InterPro IPR028777

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0005066 transmembrane receptor protein tyrosine kinase signaling protein activity CONSIDER GO:0035556
GO:0005071 transmembrane receptor protein serine/threonine kinase signaling protein activity CONSIDER GO:0035556
GO:0005076 receptor signaling protein serine/threonine kinase signaling protein activity CONSIDER GO:0035556
GO:0005081 receptor signaling protein serine/threonine phosphatase signaling protein activity CONSIDER GO:0035556
GO:0005082 receptor signaling protein tyrosine phosphatase signaling protein activity CONSIDER GO:0035556
GO:0008268 receptor signaling protein tyrosine kinase signaling protein activity CONSIDER GO:0035556

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0035556:
Relationship To GO:0035556 Child Term Child Term Name
Is a GO:0002753 cytoplasmic pattern recognition receptor signaling pathway
Is a GO:0007264 small GTPase mediated signal transduction
Is a GO:0019932 second-messenger-mediated signaling
Is a GO:0031929 TOR signaling
Is a GO:0035329 hippo signaling
Is a GO:0042770 signal transduction in response to DNA damage
Is a GO:0072331 signal transduction by p53 class mediator
Is a GO:0072395 signal transduction involved in cell cycle checkpoint
Is a GO:0039585 PKR signal transduction
Is a GO:0000160 phosphorelay signal transduction system
Is a GO:0097193 intrinsic apoptotic signaling pathway
Is a GO:0048017 inositol lipid-mediated signaling
Part of GO:0005057 receptor signaling protein activity
Is a GO:0038008 TRAF-mediated signal transduction
Is a GO:0038061 NIK/NF-kappaB signaling
Is a GO:0035424 MAPK import into nucleus involved in innate immune response
Is a GO:2000803 endosomal signal transduction
Part of GO:0000156 phosphorelay response regulator activity
Is a GO:0007227 signal transduction downstream of smoothened
Is a GO:0000165 MAPK cascade
Is a GO:0007249 I-kappaB kinase/NF-kappaB signaling
Is a GO:0007259 JAK-STAT cascade
Is a GO:0010737 protein kinase A signaling
Is a GO:0031098 stress-activated protein kinase signaling cascade
Is a GO:0043491 protein kinase B signaling
Is a GO:0070528 protein kinase C signaling
Regulates GO:1902531 regulation of intracellular signal transduction
Negatively regulates GO:1902532 negative regulation of intracellular signal transduction
Positively regulates GO:1902533 positive regulation of intracellular signal transduction

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0035556. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0035556 based on the entire annotation set Co-occurrence statistics for GO:0035556 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-04 Deleted SYNONYM intracellular signaling cascade
2013-12-04 Added SYNONYM protein kinase cascade
2013-12-04 Added SYNONYM intracellular signaling cascade
2013-12-04 Added SYNONYM intracellular protein kinase cascade
2013-12-04 Added SECONDARY GO:0007243 (intracellular protein kinase cascade)
2013-02-02 Deleted RELATION occurs in GO:0005622 (intracellular)
2011-05-27 Added RELATION occurs in GO:0005622 (intracellular)
2011-01-16 Added SECONDARY GO:0023013 (signal transmission via intracellular cascade)
2011-01-16 Added SECONDARY GO:0007242 (intracellular signaling cascade)
2011-01-16 Added SECONDARY GO:0023034 (intracellular signaling pathway)
2011-01-16 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2011-01-16 Added SYNONYM intracellular signaling pathway
2011-01-16 Added SYNONYM intracellular signal transduction pathway
2011-01-16 Added SYNONYM signal transmission via intracellular cascade
2011-01-16 Deleted SYNONYM signal transduction via intracellular signaling cascade
2011-01-16 Added SYNONYM signal transduction via intracellular signaling cascade
2010-12-17 Deleted DEFINITION The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2010-12-17 Added DEFINITION The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2010-05-16 Added TERM intracellular signal transduction
2010-05-16 Added DEFINITION The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2010-05-16 Added SYNONYM intracellular signaling chain
2010-05-16 Added SYNONYM signal transduction via intracellular signaling cascade
2010-05-16 Added SYNONYM intracellular signaling cascade
2010-05-16 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2010-05-16 Added RELATION is a GO:0007165 (signal transduction)

Term

Timestamp Action Category Detail
2010-05-16 Added TERM intracellular signal transduction

Definition/synonyms

Timestamp Action Category Detail
2013-12-04 Deleted SYNONYM intracellular signaling cascade
2013-12-04 Added SYNONYM protein kinase cascade
2013-12-04 Added SYNONYM intracellular signaling cascade
2013-12-04 Added SYNONYM intracellular protein kinase cascade
2011-01-16 Added SYNONYM intracellular signaling pathway
2011-01-16 Added SYNONYM intracellular signal transduction pathway
2011-01-16 Added SYNONYM signal transmission via intracellular cascade
2011-01-16 Deleted SYNONYM signal transduction via intracellular signaling cascade
2011-01-16 Added SYNONYM signal transduction via intracellular signaling cascade
2010-12-17 Deleted DEFINITION The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2010-12-17 Added DEFINITION The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2010-05-16 Added DEFINITION The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2010-05-16 Added SYNONYM intracellular signaling chain
2010-05-16 Added SYNONYM signal transduction via intracellular signaling cascade
2010-05-16 Added SYNONYM intracellular signaling cascade

Relationships

Timestamp Action Category Detail
2013-02-02 Deleted RELATION occurs in GO:0005622 (intracellular)
2011-05-27 Added RELATION occurs in GO:0005622 (intracellular)
2011-01-16 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-05-16 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2010-05-16 Added RELATION is a GO:0007165 (signal transduction)

Other

Timestamp Action Category Detail
2013-12-04 Added SECONDARY GO:0007243 (intracellular protein kinase cascade)
2011-01-16 Added SECONDARY GO:0023013 (signal transmission via intracellular cascade)
2011-01-16 Added SECONDARY GO:0007242 (intracellular signaling cascade)
2011-01-16 Added SECONDARY GO:0023034 (intracellular signaling pathway)
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