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GO:0007227 signal transduction downstream of smoothened

Term Information

ID GO:0007227
Name signal transduction downstream of smoothened
Ontology Biological Process
Definition The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.
PMID:15057936
GONUTS GO:0007227 Wiki Page

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Ontology Development Project
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007227:
Relationship To GO:0007227 Child Term Child Term Name
Part of GO:0007228 positive regulation of hh target transcription factor activity

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007227. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007227 based on the entire annotation set Co-occurrence statistics for GO:0007227 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-11 Added RELATION is a GO:0035556 (intracellular signal transduction)
2011-09-11 Deleted RELATION is a GO:0035557 (intracellular signal transduction involved in cell surface receptor linked signaling)
2010-05-23 Added RELATION is a GO:0035557 (intracellular signal transduction involved in cell surface receptor linked signaling)
2010-05-23 Deleted RELATION is a GO:0007165 (signal transduction)
2008-05-13 Added DEFINITION The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.
2008-05-12 Deleted DEFINITION The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.
2008-04-01 Updated RELATION is a GO:0007165 (signal transduction)
2008-04-01 Updated RELATION part of GO:0007224 (smoothened signaling pathway)
2004-12-17 Added DEFINITION The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.
2003-08-12 Updated TERM signal transduction downstream of smoothened
2002-02-06 Updated TERM signal transduction downstream of smoothened receptor
2001-11-27 Updated TERM signal transduction downstream of smoothened receptor
2001-04-03 Updated TERM signal transduction downstream of smooth receptor
2001-03-30 Added TERM signal transduction downstream of smooth receptor

Term

Timestamp Action Category Detail
2003-08-12 Updated TERM signal transduction downstream of smoothened
2002-02-06 Updated TERM signal transduction downstream of smoothened receptor
2001-11-27 Updated TERM signal transduction downstream of smoothened receptor
2001-04-03 Updated TERM signal transduction downstream of smooth receptor
2001-03-30 Added TERM signal transduction downstream of smooth receptor

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.
2008-05-12 Deleted DEFINITION The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.
2004-12-17 Added DEFINITION The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.

Relationships

Timestamp Action Category Detail
2011-09-11 Added RELATION is a GO:0035556 (intracellular signal transduction)
2011-09-11 Deleted RELATION is a GO:0035557 (intracellular signal transduction involved in cell surface receptor linked signaling)
2010-05-23 Added RELATION is a GO:0035557 (intracellular signal transduction involved in cell surface receptor linked signaling)
2010-05-23 Deleted RELATION is a GO:0007165 (signal transduction)
2008-04-01 Updated RELATION is a GO:0007165 (signal transduction)
2008-04-01 Updated RELATION part of GO:0007224 (smoothened signaling pathway)
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