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GO:0007225 patched ligand maturation

Term Information

ID GO:0007225
Name patched ligand maturation
Ontology Biological Process
Definition The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups.
PMID:15057936
GONUTS GO:0007225 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact hh protein processing
related patched ligand processing
narrow Hedgehog protein processing

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Ontology Development Project
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007225:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007225. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007225 based on the entire annotation set Co-occurrence statistics for GO:0007225 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-11-28 Added RELATION is a GO:0044710 (single-organism metabolic process)
2011-01-16 Added RELATION part of GO:0045880 (positive regulation of smoothened signaling pathway)
2011-01-16 Added RELATION is a GO:0035638 (signal maturation)
2011-01-16 Deleted RELATION part of GO:0007224 (smoothened signaling pathway)
2010-10-11 Added DEFINITION The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups.
2010-10-11 Deleted DEFINITION The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties.
2010-05-23 Added SYNONYM hh protein processing
2010-01-31 Updated TERM patched ligand maturation
2010-01-31 Added SYNONYM patched ligand processing
2010-01-31 Added RELATION is a GO:0051604 (protein maturation)
2010-01-31 Deleted RELATION is a GO:0016485 (protein processing)
2008-05-13 Added DEFINITION The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties.
2008-05-12 Deleted DEFINITION The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties.
2008-04-01 Updated RELATION is a GO:0016485 (protein processing)
2008-04-01 Updated RELATION part of GO:0007224 (smoothened signaling pathway)
2007-08-09 Added SYNONYM Hedgehog protein processing
2007-08-09 Deleted SYNONYM Hedgehog protein processing
2007-06-27 Updated DEFINITION The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties.
2004-12-17 Updated TERM patched ligand processing
2004-12-17 Added DEFINITION The post translational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties.
2004-12-17 Added SYNONYM Hedgehog protein processing
2002-02-06 Updated TERM patched receptor ligand processing
2001-04-03 Updated TERM patched receptor ligand processing
2001-03-30 Added TERM patched receptor ligand processing

Term

Timestamp Action Category Detail
2010-01-31 Updated TERM patched ligand maturation
2004-12-17 Updated TERM patched ligand processing
2002-02-06 Updated TERM patched receptor ligand processing
2001-04-03 Updated TERM patched receptor ligand processing
2001-03-30 Added TERM patched receptor ligand processing

Definition/synonyms

Timestamp Action Category Detail
2010-10-11 Added DEFINITION The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups.
2010-10-11 Deleted DEFINITION The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties.
2010-05-23 Added SYNONYM hh protein processing
2010-01-31 Added SYNONYM patched ligand processing
2008-05-13 Added DEFINITION The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties.
2008-05-12 Deleted DEFINITION The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties.
2007-08-09 Added SYNONYM Hedgehog protein processing
2007-08-09 Deleted SYNONYM Hedgehog protein processing
2007-06-27 Updated DEFINITION The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties.
2004-12-17 Added DEFINITION The post translational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties.
2004-12-17 Added SYNONYM Hedgehog protein processing

Relationships

Timestamp Action Category Detail
2013-11-28 Added RELATION is a GO:0044710 (single-organism metabolic process)
2011-01-16 Added RELATION part of GO:0045880 (positive regulation of smoothened signaling pathway)
2011-01-16 Added RELATION is a GO:0035638 (signal maturation)
2011-01-16 Deleted RELATION part of GO:0007224 (smoothened signaling pathway)
2010-01-31 Added RELATION is a GO:0051604 (protein maturation)
2010-01-31 Deleted RELATION is a GO:0016485 (protein processing)
2008-04-01 Updated RELATION is a GO:0016485 (protein processing)
2008-04-01 Updated RELATION part of GO:0007224 (smoothened signaling pathway)
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