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GO:0007224 smoothened signaling pathway

Term Information

ID GO:0007224
Name smoothened signaling pathway
Ontology Biological Process
Definition A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
PMID:15205520
GONUTS GO:0007224 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow Sonic hedgehog signaling pathway
related Shh signaling pathway
narrow hh signalling pathway
narrow hh signaling pathway
exact smoothened signalling pathway
exact hedgehog signaling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR022076
InterPro IPR026501
InterPro IPR026544
InterPro IPR026582
InterPro IPR029246
Wikipedia Hedgehog_signaling_pathway

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007224:
Relationship To GO:0007224 Child Term Child Term Name
Regulates GO:0008589 regulation of smoothened signaling pathway
Part of GO:0007227 signal transduction downstream of smoothened
Part of GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway
Is a GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
Negatively regulates GO:0045879 negative regulation of smoothened signaling pathway
Positively regulates GO:0045880 positive regulation of smoothened signaling pathway
Is a GO:0003435 smoothened signaling pathway involved in growth plate cartilage chondrocyte development
Is a GO:0060506 smoothened signaling pathway involved in lung development
Is a GO:0003271 smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation
Is a GO:0060783 mesenchymal smoothened signaling pathway involved in prostate gland development
Is a GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning
Is a GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Date
Assigned By
Product Form ID
Name
Synonym
Type
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007224. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007224 based on the entire annotation set Co-occurrence statistics for GO:0007224 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-18 Added DEFINITION A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2012-01-18 Deleted DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2011-04-21 Added SYNONYM hh signalling pathway
2011-04-21 Added SYNONYM Shh signaling pathway
2011-04-21 Added SYNONYM hh signaling pathway
2011-04-21 Added SYNONYM Sonic hedgehog signaling pathway
2011-04-21 Deleted SYNONYM hh signaling pathway
2011-04-21 Deleted SYNONYM hh signalling pathway
2010-04-14 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2009-03-02 Added XREF Wikipedia:Hedgehog_signaling_pathway
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2008-04-01 Updated RELATION is a GO:0007166 (cell surface receptor signaling pathway)
2007-08-09 Added SYNONYM hh signalling pathway
2007-08-09 Added SYNONYM smoothened signalling pathway
2007-08-09 Added SYNONYM hedgehog signaling pathway
2007-08-09 Added SYNONYM hh signaling pathway
2007-08-09 Deleted SYNONYM hedgehog signaling pathway
2007-08-09 Deleted SYNONYM hh signaling pathway
2007-08-09 Deleted SYNONYM hh signalling pathway
2007-08-09 Deleted SYNONYM smoothened signalling pathway
2004-12-17 Updated TERM smoothened signaling pathway
2004-12-17 Deleted SYNONYM smoothened signaling pathway
2004-12-17 Added SYNONYM hedgehog signaling pathway
2004-10-08 Added SYNONYM hh signalling pathway
2004-07-15 Updated DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2004-07-14 Added DEFINITION The series of molecular signals generated as a consequence of a smoothened receptor binding to one of its physiological ligands.
2004-04-19 Added SYNONYM hh signaling pathway
2004-04-19 Added SYNONYM smoothened signaling pathway
2004-04-19 Added SYNONYM smoothened signalling pathway
2004-04-16 Deleted SYNONYM hh signaling pathway
2004-04-16 Deleted SYNONYM smoothened signaling pathway
2004-04-16 Deleted SYNONYM smoothened signalling pathway
2003-12-20 Updated TERM smoothened receptor signaling pathway
2003-12-20 Added SYNONYM smoothened signaling pathway
2003-11-13 Added SYNONYM smoothened signalling pathway
2003-08-12 Updated TERM smoothened signaling pathway
2002-08-05 Updated TERM smoothened receptor signaling pathway
2002-02-06 Updated TERM smo receptor signaling pathway
2001-04-03 Updated TERM smo receptor signaling pathway
2001-03-30 Added SYNONYM hh signaling pathway
2001-03-30 Added TERM smo receptor signaling pathway

Term

Timestamp Action Category Detail
2004-12-17 Updated TERM smoothened signaling pathway
2003-12-20 Updated TERM smoothened receptor signaling pathway
2003-08-12 Updated TERM smoothened signaling pathway
2002-08-05 Updated TERM smoothened receptor signaling pathway
2002-02-06 Updated TERM smo receptor signaling pathway
2001-04-03 Updated TERM smo receptor signaling pathway
2001-03-30 Added TERM smo receptor signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-01-18 Added DEFINITION A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2012-01-18 Deleted DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2011-04-21 Added SYNONYM hh signalling pathway
2011-04-21 Added SYNONYM Shh signaling pathway
2011-04-21 Added SYNONYM hh signaling pathway
2011-04-21 Added SYNONYM Sonic hedgehog signaling pathway
2011-04-21 Deleted SYNONYM hh signaling pathway
2011-04-21 Deleted SYNONYM hh signalling pathway
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2007-08-09 Added SYNONYM hh signalling pathway
2007-08-09 Added SYNONYM smoothened signalling pathway
2007-08-09 Added SYNONYM hedgehog signaling pathway
2007-08-09 Added SYNONYM hh signaling pathway
2007-08-09 Deleted SYNONYM hedgehog signaling pathway
2007-08-09 Deleted SYNONYM hh signaling pathway
2007-08-09 Deleted SYNONYM hh signalling pathway
2007-08-09 Deleted SYNONYM smoothened signalling pathway
2004-12-17 Deleted SYNONYM smoothened signaling pathway
2004-12-17 Added SYNONYM hedgehog signaling pathway
2004-10-08 Added SYNONYM hh signalling pathway
2004-07-15 Updated DEFINITION The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2004-07-14 Added DEFINITION The series of molecular signals generated as a consequence of a smoothened receptor binding to one of its physiological ligands.
2004-04-19 Added SYNONYM hh signaling pathway
2004-04-19 Added SYNONYM smoothened signaling pathway
2004-04-19 Added SYNONYM smoothened signalling pathway
2004-04-16 Deleted SYNONYM hh signaling pathway
2004-04-16 Deleted SYNONYM smoothened signaling pathway
2004-04-16 Deleted SYNONYM smoothened signalling pathway
2003-12-20 Added SYNONYM smoothened signaling pathway
2003-11-13 Added SYNONYM smoothened signalling pathway
2001-03-30 Added SYNONYM hh signaling pathway

Relationships

Timestamp Action Category Detail
2010-04-14 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2008-04-01 Updated RELATION is a GO:0007166 (cell surface receptor signaling pathway)

Cross-references

Timestamp Action Category Detail
2009-03-02 Added XREF Wikipedia:Hedgehog_signaling_pathway
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