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GO:0007219 Notch signaling pathway

Term Information

ID GO:0007219
Name Notch signaling pathway
Ontology Biological Process
Definition A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Secondary IDs GO:0030179
GONUTS GO:0007219 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact Notch-receptor signalling pathway
exact Notch-receptor signaling pathway
exact Notch receptor signalling pathway
exact Notch receptor signaling pathway
exact N signalling pathway
exact N signaling pathway
exact Notch signalling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR011651
InterPro IPR011656
InterPro IPR019082
InterPro IPR022331
InterPro IPR022362
InterPro IPR026219
InterPro IPR027053
InterPro IPR029686
UniProtKB-KW Notch signaling pathway
Wikipedia Notch_signaling_pathway

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007219:
Relationship To GO:0007219 Child Term Child Term Name
Regulates GO:0008593 regulation of Notch signaling pathway
Part of GO:0007221 positive regulation of transcription of Notch receptor target
Is a GO:0061314 Notch signaling involved in heart development
Is a GO:0060227 Notch signaling pathway involved in camera-type eye photoreceptor fate commitment
Negatively regulates GO:0045746 negative regulation of Notch signaling pathway
Positively regulates GO:0045747 positive regulation of Notch signaling pathway
Is a GO:0060853 Notch signaling pathway involved in arterial endothelial cell fate commitment
Is a GO:0021876 Notch signaling pathway involved in forebrain neuroblast division
Is a GO:0021880 Notch signaling pathway involved in forebrain neuron fate commitment
Part of GO:0035333 Notch receptor processing, ligand-dependent
Is a GO:1902359 Notch signaling pathway involved in somitogenesis
Is a GO:2000796 Notch signaling pathway involved in negative regulation of venous endothelial cell fate commitment

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007219. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007219 based on the entire annotation set Co-occurrence statistics for GO:0007219 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-18 Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 Deleted DEFINITION The series of molecular signals initiated by binding of the receptor Notch to an extracellular ligand.
2011-09-09 Added DEFINITION The series of molecular signals initiated by binding of the receptor Notch to an extracellular ligand.
2011-09-09 Deleted DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
2010-04-14 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2009-03-02 Added XREF Wikipedia:Notch_signaling_pathway
2008-05-13 Added DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
2008-05-12 Deleted DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
2008-04-01 Updated RELATION is a GO:0007166 (cell surface receptor signaling pathway)
2007-08-09 Added SYNONYM N signaling pathway
2007-08-09 Added SYNONYM N signalling pathway
2007-08-09 Added SYNONYM Notch receptor signaling pathway
2007-08-09 Added SYNONYM Notch receptor signalling pathway
2007-08-09 Added SYNONYM Notch signalling pathway
2007-08-09 Added SYNONYM Notch-receptor signaling pathway
2007-08-09 Added SYNONYM Notch-receptor signalling pathway
2007-08-09 Deleted SYNONYM N signalling pathway
2007-08-09 Deleted SYNONYM Notch receptor signaling pathway
2007-08-09 Deleted SYNONYM Notch receptor signalling pathway
2007-08-09 Deleted SYNONYM Notch signalling pathway
2007-08-09 Deleted SYNONYM Notch-receptor signaling pathway
2007-08-09 Deleted SYNONYM Notch-receptor signalling pathway
2007-08-09 Deleted SYNONYM N signaling pathway
2005-12-15 Added SYNONYM Notch receptor signaling pathway
2005-12-15 Added SYNONYM Notch receptor signalling pathway
2005-12-15 Added SYNONYM Notch-receptor signaling pathway
2005-12-15 Added SYNONYM Notch-receptor signalling pathway
2004-10-08 Added SYNONYM Notch signalling pathway
2004-07-14 Updated DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
2004-04-19 Added SYNONYM N signaling pathway
2004-04-19 Added SYNONYM N signalling pathway
2004-04-16 Deleted SYNONYM N signaling pathway
2004-04-16 Deleted SYNONYM N signalling pathway
2004-02-12 Added SYNONYM N signaling pathway
2004-02-12 Deleted SYNONYM Notch signaling pathway
2004-02-12 Updated TERM Notch signaling pathway
2003-11-13 Added SYNONYM N signalling pathway
2003-08-16 Updated DEFINITION A pathway of signal transduction initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
2003-08-07 Deleted SYNONYM Notch receptor signaling pathway
2003-08-07 Added DEFINITION A pathway of signal transduction initiated by binding of a ligand to an extracellular ligand to a Notch receptor on the surface of the target cell.
2003-08-07 Added SYNONYM Notch signaling pathway
2003-08-07 Updated TERM N signaling pathway
2002-02-06 Updated TERM N receptor signaling pathway
2001-11-07 Added SECONDARY GO:0030179 (Notch receptor signaling pathway)
2001-04-03 Updated TERM N receptor signaling pathway
2001-03-30 Added SYNONYM Notch receptor signaling pathway
2001-03-30 Added TERM N receptor signaling pathway

Term

Timestamp Action Category Detail
2004-02-12 Updated TERM Notch signaling pathway
2003-08-07 Updated TERM N signaling pathway
2002-02-06 Updated TERM N receptor signaling pathway
2001-04-03 Updated TERM N receptor signaling pathway
2001-03-30 Added TERM N receptor signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-01-18 Added DEFINITION A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 Deleted DEFINITION The series of molecular signals initiated by binding of the receptor Notch to an extracellular ligand.
2011-09-09 Added DEFINITION The series of molecular signals initiated by binding of the receptor Notch to an extracellular ligand.
2011-09-09 Deleted DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
2008-05-13 Added DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
2008-05-12 Deleted DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
2007-08-09 Added SYNONYM N signaling pathway
2007-08-09 Added SYNONYM N signalling pathway
2007-08-09 Added SYNONYM Notch receptor signaling pathway
2007-08-09 Added SYNONYM Notch receptor signalling pathway
2007-08-09 Added SYNONYM Notch signalling pathway
2007-08-09 Added SYNONYM Notch-receptor signaling pathway
2007-08-09 Added SYNONYM Notch-receptor signalling pathway
2007-08-09 Deleted SYNONYM N signalling pathway
2007-08-09 Deleted SYNONYM Notch receptor signaling pathway
2007-08-09 Deleted SYNONYM Notch receptor signalling pathway
2007-08-09 Deleted SYNONYM Notch signalling pathway
2007-08-09 Deleted SYNONYM Notch-receptor signaling pathway
2007-08-09 Deleted SYNONYM Notch-receptor signalling pathway
2007-08-09 Deleted SYNONYM N signaling pathway
2005-12-15 Added SYNONYM Notch receptor signaling pathway
2005-12-15 Added SYNONYM Notch receptor signalling pathway
2005-12-15 Added SYNONYM Notch-receptor signaling pathway
2005-12-15 Added SYNONYM Notch-receptor signalling pathway
2004-10-08 Added SYNONYM Notch signalling pathway
2004-07-14 Updated DEFINITION The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
2004-04-19 Added SYNONYM N signaling pathway
2004-04-19 Added SYNONYM N signalling pathway
2004-04-16 Deleted SYNONYM N signaling pathway
2004-04-16 Deleted SYNONYM N signalling pathway
2004-02-12 Added SYNONYM N signaling pathway
2004-02-12 Deleted SYNONYM Notch signaling pathway
2003-11-13 Added SYNONYM N signalling pathway
2003-08-16 Updated DEFINITION A pathway of signal transduction initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.
2003-08-07 Deleted SYNONYM Notch receptor signaling pathway
2003-08-07 Added DEFINITION A pathway of signal transduction initiated by binding of a ligand to an extracellular ligand to a Notch receptor on the surface of the target cell.
2003-08-07 Added SYNONYM Notch signaling pathway
2001-03-30 Added SYNONYM Notch receptor signaling pathway

Relationships

Timestamp Action Category Detail
2010-04-14 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2008-04-01 Updated RELATION is a GO:0007166 (cell surface receptor signaling pathway)

Cross-references

Timestamp Action Category Detail
2009-03-02 Added XREF Wikipedia:Notch_signaling_pathway

Other

Timestamp Action Category Detail
2001-11-07 Added SECONDARY GO:0030179 (Notch receptor signaling pathway)
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