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GO:0007193 inhibition of adenylate cyclase activity by G-protein signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP.

Term Information

ID	GO:0007193
Name	inhibition of adenylate cyclase activity by G-protein signaling pathway
Ontology	Biological Process
Definition	The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP.
Comment

Synonyms

Type	Synonym
exact	G protein signaling, adenylate cyclase inhibiting pathway
exact	G-protein signaling, adenylate cyclase inhibiting pathway
exact	G protein signaling, adenylyl cyclase inhibiting pathway
exact	G-protein signalling, adenylyl cyclase inhibiting pathway
exact	G-protein signalling, adenylate cyclase inhibiting pathway
exact	G-protein signaling, adenylyl cyclase inhibiting pathway
exact	G protein signalling, adenylyl cyclase inhibiting pathway
exact	G protein signalling, adenylate cyclase inhibiting pathway

Web service: term information

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GTerm?id=termID&format=format

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Ancestor Chart

Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term. Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms by one or more 'relationships'

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.

GO:0008150 biological_process

GO:0065007 biological regulation

GO:0008152 metabolic process

GO:0009987 cellular process

GO:0006807 nitrogen compound metabolic process

GO:0009058 biosynthetic process

GO:0050789 regulation of biological process

GO:0044238 primary metabolic process

GO:0065009 regulation of molecular function

GO:0007154 cell communication

GO:0050790 regulation of catalytic activity

GO:0044092 negative regulation of molecular function

GO:0044237 cellular metabolic process

GO:0051339 regulation of lyase activity

GO:0050794 regulation of cellular process

GO:0019222 regulation of metabolic process

GO:0046483 heterocycle metabolic process

GO:0043086 negative regulation of catalytic activity

GO:0044249 cellular biosynthetic process

GO:0009889 regulation of biosynthetic process

GO:0080090 regulation of primary metabolic process

GO:0051171 regulation of nitrogen compound metabolic process

GO:0007165 signal transduction

GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

GO:0051350 negative regulation of lyase activity

GO:0055086 nucleobase, nucleoside and nucleotide metabolic process

GO:0007242 intracellular signaling cascade

GO:0007166 cell surface receptor linked signal transduction

GO:0006753 nucleoside phosphate metabolic process

GO:0007186 G-protein coupled receptor protein signaling pathway

GO:0019932 second-messenger-mediated signaling

GO:0031323 regulation of cellular metabolic process

GO:0019935 cyclic-nucleotide-mediated signaling

GO:0009117 nucleotide metabolic process

GO:0019933 cAMP-mediated signaling

GO:0009123 nucleoside monophosphate metabolic process

GO:0006163 purine nucleotide metabolic process

GO:0009187 cyclic nucleotide metabolic process

GO:0009165 nucleotide biosynthetic process

GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger

GO:0031326 regulation of cellular biosynthetic process

GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger

GO:0009124 nucleoside monophosphate biosynthetic process

GO:0046058 cAMP metabolic process

GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

GO:0006164 purine nucleotide biosynthetic process

GO:0009190 cyclic nucleotide biosynthetic process

GO:0006140 regulation of nucleotide metabolic process

GO:0006171 cAMP biosynthetic process

GO:0030799 regulation of cyclic nucleotide metabolic process

GO:0030808 regulation of nucleotide biosynthetic process

GO:0030814 regulation of cAMP metabolic process

GO:0030802 regulation of cyclic nucleotide biosynthetic process

GO:0031279 regulation of cyclase activity

GO:0031280 negative regulation of cyclase activity

GO:0030817 regulation of cAMP biosynthetic process

GO:0045761 regulation of adenylate cyclase activity

GO:0007194 negative regulation of adenylate cyclase activity

GO:0007193 inhibition of adenylate cyclase activity by G-protein signaling pathway

Relationship key

Code	Relationship
	part of
	is a
	regulates
	+ve regulates
	-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:

I	GO:0031635 inhibition of adenylate cyclase activity by opioid receptor signaling pathway
I	GO:0007195 inhibition of adenylate cyclase activity by dopamine receptor signaling pathway
I	GO:0007196 inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway
I	GO:0007197 inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway
I	GO:0007198 inhibition of adenylate cyclase activity by serotonin receptor signaling pathway

Relationship key

Code	Relationship
P	part of
I	is a

Protein Annotation

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Web service: annotation

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GAnnotation?format=tsv&limit=max-number-of-rows{&gz}{&q=advanced query}{&field=value{,value}}

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Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.

Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.

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