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GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway

Term Information

ID GO:0007189
Name adenylate cyclase-activating G-protein coupled receptor signaling pathway
Ontology Biological Process
Definition The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
Comment This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway ; GO:0010579.
Secondary IDs GO:0010580
GONUTS GO:0007189 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact G-protein signalling, adenylate cyclase activating pathway
exact G-protein signaling, adenylyl cyclase activating pathway
exact G protein signalling, adenylyl cyclase activating pathway
exact G protein signalling, adenylate cyclase activating pathway
exact G protein signaling, adenylyl cyclase activating pathway
exact G protein signaling, adenylate cyclase activating pathway
exact G-protein signalling, adenylyl cyclase activating pathway
exact G-protein signaling, adenylate cyclase activating pathway
exact GPCR signaling pathway via activation of adenylate cyclase
related activation of adenylate cyclase activity involved in G-protein signaling
exact adenylate cyclase-activating GPCR signaling pathway
exact GPCR signaling pathway via activation of adenylate cyclase activity
related activation of adenylate cyclase activity by G-protein signaling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR000332
InterPro IPR000507
InterPro IPR000681
InterPro IPR002975

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007189:
Relationship To GO:0007189 Child Term Child Term Name
Is a GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
Is a GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
Is a GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway
Is a GO:0010619 adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway
Has part GO:0007190 activation of adenylate cyclase activity
Part of GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
Has part GO:0043950 positive regulation of cAMP-mediated signaling

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007189. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007189 based on the entire annotation set Co-occurrence statistics for GO:0007189 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-05-27 Deleted RELATION is a GO:0007190 (activation of adenylate cyclase activity)
2012-05-27 Deleted RELATION is a GO:0010579 (positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway)
2012-05-27 Added SYNONYM GPCR signaling pathway via activation of adenylate cyclase activity
2012-05-27 Deleted SYNONYM activation of adenylate cyclase activity involved in G-protein signaling
2012-05-27 Added SYNONYM activation of adenylate cyclase activity involved in G-protein signaling
2012-05-27 Added SYNONYM adenylate cyclase-activating GPCR signaling pathway
2012-05-27 Added SYNONYM GPCR signaling pathway via activation of adenylate cyclase
2012-05-27 Added SYNONYM activation of adenylate cyclase activity by G-protein signaling pathway
2012-05-27 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
2012-05-27 Updated TERM adenylate cyclase-activating G-protein coupled receptor signaling pathway
2012-05-27 Deleted DEFINITION Any process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP.
2010-06-09 Updated TERM activation of adenylate cyclase activity by G-protein signaling pathway
2010-06-08 Updated TERM activation of adenylate cyclase activity by G-protein signaling pathway
2009-02-25 Updated TERM activation of adenylate cyclase activity by G-protein signaling pathway
2009-02-22 Updated TERM activation of adenylate cyclase activity by G-protein signaling pathway
2009-01-31 Updated TERM activation of adenylate cyclase activity by G-protein signaling pathway
2009-01-31 Added DEFINITION Any process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP.
2009-01-31 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP.
2009-01-31 Added SYNONYM activation of adenylate cyclase activity involved in G-protein signaling
2009-01-31 Added SYNONYM G-protein signaling, adenylate cyclase activating pathway
2009-01-31 Added RELATION is a GO:0010579 (positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway)
2009-01-31 Added RELATION is a GO:0007190 (activation of adenylate cyclase activity)
2009-01-31 Deleted RELATION is a GO:0045762 (positive regulation of adenylate cyclase activity)
2009-01-31 Added SECONDARY GO:0010580 (activation of adenylate cyclase activity involved in G-protein signaling)
2008-10-02 Added RELATION is a GO:0045762 (positive regulation of adenylate cyclase activity)
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP.
2008-04-01 Updated RELATION is a GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
2007-08-09 Added SYNONYM G protein signaling, adenylate cyclase activating pathway
2007-08-09 Added SYNONYM G protein signaling, adenylyl cyclase activating pathway
2007-08-09 Added SYNONYM G protein signalling, adenylate cyclase activating pathway
2007-08-09 Added SYNONYM G protein signalling, adenylyl cyclase activating pathway
2007-08-09 Added SYNONYM G-protein signaling, adenylyl cyclase activating pathway
2007-08-09 Added SYNONYM G-protein signalling, adenylate cyclase activating pathway
2007-08-09 Added SYNONYM G-protein signalling, adenylyl cyclase activating pathway
2007-08-09 Deleted SYNONYM G protein signaling, adenylate cyclase activating pathway
2007-08-09 Deleted SYNONYM G protein signaling, adenylyl cyclase activating pathway
2007-08-09 Deleted SYNONYM G protein signalling, adenylate cyclase activating pathway
2007-08-09 Deleted SYNONYM G protein signalling, adenylyl cyclase activating pathway
2007-08-09 Deleted SYNONYM G-protein signaling, adenylyl cyclase activating pathway
2007-08-09 Deleted SYNONYM G-protein signalling, adenylate cyclase activating pathway
2007-08-09 Deleted SYNONYM G-protein signalling, adenylyl cyclase activating pathway
2005-06-27 Added SYNONYM G protein signaling, adenylate cyclase activating pathway
2005-06-27 Added SYNONYM G protein signaling, adenylyl cyclase activating pathway
2005-06-27 Added SYNONYM G protein signalling, adenylate cyclase activating pathway
2005-06-27 Added SYNONYM G protein signalling, adenylyl cyclase activating pathway
2005-06-27 Added SYNONYM G-protein signalling, adenylyl cyclase activating pathway
2004-09-03 Added SYNONYM G-protein signaling, adenylyl cyclase activating pathway
2004-07-28 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP.
2004-04-19 Added SYNONYM G-protein signalling, adenylate cyclase activating pathway
2004-04-16 Deleted SYNONYM G-protein signalling, adenylate cyclase activating pathway
2003-11-13 Added SYNONYM G-protein signalling, adenylate cyclase activating pathway
2002-02-06 Updated TERM G-protein signaling, adenylate cyclase activating pathway
2001-04-03 Updated TERM G-protein signaling, adenylate cyclase activating pathway
2001-03-30 Added TERM G-protein signaling, adenylate cyclase activating pathway

Term

Timestamp Action Category Detail
2012-05-27 Updated TERM adenylate cyclase-activating G-protein coupled receptor signaling pathway
2010-06-09 Updated TERM activation of adenylate cyclase activity by G-protein signaling pathway
2010-06-08 Updated TERM activation of adenylate cyclase activity by G-protein signaling pathway
2009-02-25 Updated TERM activation of adenylate cyclase activity by G-protein signaling pathway
2009-02-22 Updated TERM activation of adenylate cyclase activity by G-protein signaling pathway
2009-01-31 Updated TERM activation of adenylate cyclase activity by G-protein signaling pathway
2002-02-06 Updated TERM G-protein signaling, adenylate cyclase activating pathway
2001-04-03 Updated TERM G-protein signaling, adenylate cyclase activating pathway
2001-03-30 Added TERM G-protein signaling, adenylate cyclase activating pathway

Definition/synonyms

Timestamp Action Category Detail
2012-05-27 Added SYNONYM GPCR signaling pathway via activation of adenylate cyclase activity
2012-05-27 Deleted SYNONYM activation of adenylate cyclase activity involved in G-protein signaling
2012-05-27 Added SYNONYM activation of adenylate cyclase activity involved in G-protein signaling
2012-05-27 Added SYNONYM adenylate cyclase-activating GPCR signaling pathway
2012-05-27 Added SYNONYM GPCR signaling pathway via activation of adenylate cyclase
2012-05-27 Added SYNONYM activation of adenylate cyclase activity by G-protein signaling pathway
2012-05-27 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
2012-05-27 Deleted DEFINITION Any process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP.
2009-01-31 Added DEFINITION Any process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP.
2009-01-31 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP.
2009-01-31 Added SYNONYM activation of adenylate cyclase activity involved in G-protein signaling
2009-01-31 Added SYNONYM G-protein signaling, adenylate cyclase activating pathway
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP.
2007-08-09 Added SYNONYM G protein signaling, adenylate cyclase activating pathway
2007-08-09 Added SYNONYM G protein signaling, adenylyl cyclase activating pathway
2007-08-09 Added SYNONYM G protein signalling, adenylate cyclase activating pathway
2007-08-09 Added SYNONYM G protein signalling, adenylyl cyclase activating pathway
2007-08-09 Added SYNONYM G-protein signaling, adenylyl cyclase activating pathway
2007-08-09 Added SYNONYM G-protein signalling, adenylate cyclase activating pathway
2007-08-09 Added SYNONYM G-protein signalling, adenylyl cyclase activating pathway
2007-08-09 Deleted SYNONYM G protein signaling, adenylate cyclase activating pathway
2007-08-09 Deleted SYNONYM G protein signaling, adenylyl cyclase activating pathway
2007-08-09 Deleted SYNONYM G protein signalling, adenylate cyclase activating pathway
2007-08-09 Deleted SYNONYM G protein signalling, adenylyl cyclase activating pathway
2007-08-09 Deleted SYNONYM G-protein signaling, adenylyl cyclase activating pathway
2007-08-09 Deleted SYNONYM G-protein signalling, adenylate cyclase activating pathway
2007-08-09 Deleted SYNONYM G-protein signalling, adenylyl cyclase activating pathway
2005-06-27 Added SYNONYM G protein signaling, adenylate cyclase activating pathway
2005-06-27 Added SYNONYM G protein signaling, adenylyl cyclase activating pathway
2005-06-27 Added SYNONYM G protein signalling, adenylate cyclase activating pathway
2005-06-27 Added SYNONYM G protein signalling, adenylyl cyclase activating pathway
2005-06-27 Added SYNONYM G-protein signalling, adenylyl cyclase activating pathway
2004-09-03 Added SYNONYM G-protein signaling, adenylyl cyclase activating pathway
2004-07-28 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP.
2004-04-19 Added SYNONYM G-protein signalling, adenylate cyclase activating pathway
2004-04-16 Deleted SYNONYM G-protein signalling, adenylate cyclase activating pathway
2003-11-13 Added SYNONYM G-protein signalling, adenylate cyclase activating pathway

Relationships

Timestamp Action Category Detail
2012-05-27 Deleted RELATION is a GO:0007190 (activation of adenylate cyclase activity)
2012-05-27 Deleted RELATION is a GO:0010579 (positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway)
2009-01-31 Added RELATION is a GO:0010579 (positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway)
2009-01-31 Added RELATION is a GO:0007190 (activation of adenylate cyclase activity)
2009-01-31 Deleted RELATION is a GO:0045762 (positive regulation of adenylate cyclase activity)
2008-10-02 Added RELATION is a GO:0045762 (positive regulation of adenylate cyclase activity)
2008-04-01 Updated RELATION is a GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)

Other

Timestamp Action Category Detail
2009-01-31 Added SECONDARY GO:0010580 (activation of adenylate cyclase activity involved in G-protein signaling)
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