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GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway

Term Information

ID GO:0007188
Name adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Ontology Biological Process
Definition The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
Comment This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway ; GO:0010578.
GONUTS GO:0007188 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact G protein signaling, coupled to cAMP nucleotide second messenger
exact G protein signaling, coupled to cyclic AMP nucleotide second messenger
exact G protein signalling, coupled to cAMP nucleotide second messenger
exact G protein signalling, coupled to cyclic AMP nucleotide second messenger
exact G-protein signaling, coupled to cyclic AMP nucleotide second messenger
exact G-protein signalling, coupled to cAMP nucleotide second messenger
exact G-protein signalling, coupled to cyclic AMP nucleotide second messenger
exact adenylate cyclase-modulating GPCR signaling pathway
exact GPCR signaling pathway via cAMP second messenger
exact GPCR signaling pathway via modulation of adenylate cyclase activity
exact G-protein signaling, coupled to cAMP nucleotide second messenger

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR001408

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007188:
Relationship To GO:0007188 Child Term Child Term Name
Is a GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
Is a GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
Part of GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
Has part GO:0019933 cAMP-mediated signaling
Has part GO:0045761 regulation of adenylate cyclase activity
Has part GO:0043949 regulation of cAMP-mediated signaling

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007188. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007188 based on the entire annotation set Co-occurrence statistics for GO:0007188 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-05-27 Deleted RELATION is a GO:0019933 (cAMP-mediated signaling)
2012-05-27 Added SYNONYM G-protein signaling, coupled to cAMP nucleotide second messenger
2012-05-27 Added SYNONYM GPCR signaling pathway via cAMP second messenger
2012-05-27 Added SYNONYM GPCR signaling pathway via modulation of adenylate cyclase activity
2012-05-27 Added SYNONYM adenylate cyclase-modulating GPCR signaling pathway
2012-05-27 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
2012-05-27 Updated TERM adenylate cyclase-modulating G-protein coupled receptor signaling pathway
2012-05-27 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.
2008-04-01 Updated RELATION is a GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
2008-04-01 Updated RELATION is a GO:0019933 (cAMP-mediated signaling)
2007-08-09 Added SYNONYM G protein signaling, coupled to cAMP nucleotide second messenger
2007-08-09 Added SYNONYM G protein signaling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Added SYNONYM G protein signalling, coupled to cAMP nucleotide second messenger
2007-08-09 Added SYNONYM G protein signalling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Added SYNONYM G-protein signaling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Added SYNONYM G-protein signalling, coupled to cAMP nucleotide second messenger
2007-08-09 Added SYNONYM G-protein signalling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G protein signaling, coupled to cAMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G protein signaling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G protein signalling, coupled to cAMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G protein signalling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G-protein signaling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G-protein signalling, coupled to cAMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G-protein signalling, coupled to cyclic AMP nucleotide second messenger
2005-12-26 Added SYNONYM G protein signaling, coupled to cyclic AMP nucleotide second messenger
2005-12-26 Added SYNONYM G protein signalling, coupled to cyclic AMP nucleotide second messenger
2005-12-26 Added SYNONYM G-protein signaling, coupled to cyclic AMP nucleotide second messenger
2005-12-26 Added SYNONYM G-protein signalling, coupled to cyclic AMP nucleotide second messenger
2005-06-27 Added SYNONYM G protein signaling, coupled to cAMP nucleotide second messenger
2005-06-27 Added SYNONYM G protein signalling, coupled to cAMP nucleotide second messenger
2004-07-28 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.
2004-04-19 Added SYNONYM G-protein signalling, coupled to cAMP nucleotide second messenger
2004-04-16 Deleted SYNONYM G-protein signalling, coupled to cAMP nucleotide second messenger
2003-11-13 Added SYNONYM G-protein signalling, coupled to cAMP nucleotide second messenger
2002-02-06 Updated TERM G-protein signaling, coupled to cAMP nucleotide second messenger
2001-04-03 Updated TERM G-protein signaling, coupled to cAMP nucleotide second messenger
2001-03-30 Added TERM G-protein signaling, coupled to cAMP nucleotide second messenger

Term

Timestamp Action Category Detail
2012-05-27 Updated TERM adenylate cyclase-modulating G-protein coupled receptor signaling pathway
2002-02-06 Updated TERM G-protein signaling, coupled to cAMP nucleotide second messenger
2001-04-03 Updated TERM G-protein signaling, coupled to cAMP nucleotide second messenger
2001-03-30 Added TERM G-protein signaling, coupled to cAMP nucleotide second messenger

Definition/synonyms

Timestamp Action Category Detail
2012-05-27 Added SYNONYM G-protein signaling, coupled to cAMP nucleotide second messenger
2012-05-27 Added SYNONYM GPCR signaling pathway via cAMP second messenger
2012-05-27 Added SYNONYM GPCR signaling pathway via modulation of adenylate cyclase activity
2012-05-27 Added SYNONYM adenylate cyclase-modulating GPCR signaling pathway
2012-05-27 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
2012-05-27 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.
2007-08-09 Added SYNONYM G protein signaling, coupled to cAMP nucleotide second messenger
2007-08-09 Added SYNONYM G protein signaling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Added SYNONYM G protein signalling, coupled to cAMP nucleotide second messenger
2007-08-09 Added SYNONYM G protein signalling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Added SYNONYM G-protein signaling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Added SYNONYM G-protein signalling, coupled to cAMP nucleotide second messenger
2007-08-09 Added SYNONYM G-protein signalling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G protein signaling, coupled to cAMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G protein signaling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G protein signalling, coupled to cAMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G protein signalling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G-protein signaling, coupled to cyclic AMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G-protein signalling, coupled to cAMP nucleotide second messenger
2007-08-09 Deleted SYNONYM G-protein signalling, coupled to cyclic AMP nucleotide second messenger
2005-12-26 Added SYNONYM G protein signaling, coupled to cyclic AMP nucleotide second messenger
2005-12-26 Added SYNONYM G protein signalling, coupled to cyclic AMP nucleotide second messenger
2005-12-26 Added SYNONYM G-protein signaling, coupled to cyclic AMP nucleotide second messenger
2005-12-26 Added SYNONYM G-protein signalling, coupled to cyclic AMP nucleotide second messenger
2005-06-27 Added SYNONYM G protein signaling, coupled to cAMP nucleotide second messenger
2005-06-27 Added SYNONYM G protein signalling, coupled to cAMP nucleotide second messenger
2004-07-28 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.
2004-04-19 Added SYNONYM G-protein signalling, coupled to cAMP nucleotide second messenger
2004-04-16 Deleted SYNONYM G-protein signalling, coupled to cAMP nucleotide second messenger
2003-11-13 Added SYNONYM G-protein signalling, coupled to cAMP nucleotide second messenger

Relationships

Timestamp Action Category Detail
2012-05-27 Deleted RELATION is a GO:0019933 (cAMP-mediated signaling)
2008-04-01 Updated RELATION is a GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
2008-04-01 Updated RELATION is a GO:0019933 (cAMP-mediated signaling)
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