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GO:0007186 G-protein coupled receptor signaling pathway

Term Information

ID GO:0007186
Name G-protein coupled receptor signaling pathway
Ontology Biological Process
Definition A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
GONUTS GO:0007186 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact GPCR signaling pathway
exact G-protein coupled receptor signalling pathway
exact G-protein coupled receptor protein signaling pathway
exact G protein coupled receptor protein signalling pathway
exact G protein coupled receptor protein signaling pathway
exact G-protein coupled receptor protein signal transduction
exact G-protein-coupled receptor protein signalling pathway
exact G-protein-coupled receptor protein signaling pathway
exact GPCR signalling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR000018
InterPro IPR000025
InterPro IPR000046
InterPro IPR000057
InterPro IPR000068
InterPro IPR000105
InterPro IPR000112
InterPro IPR000141
InterPro IPR000144
InterPro IPR000147
InterPro IPR000154
InterPro IPR000155
InterPro IPR000161
InterPro IPR000162
InterPro IPR000174
InterPro IPR000190
InterPro IPR000202
InterPro IPR000204
InterPro IPR000207
InterPro IPR000248
InterPro IPR000265
InterPro IPR000276
InterPro IPR000314
InterPro IPR000321
InterPro IPR000337
InterPro IPR000351
InterPro IPR000355
InterPro IPR000363
InterPro IPR000366
InterPro IPR000367
InterPro IPR000370
InterPro IPR000376
InterPro IPR000377
InterPro IPR000378
InterPro IPR000393
InterPro IPR000405
InterPro IPR000431
InterPro IPR000450
InterPro IPR000452
InterPro IPR000455
InterPro IPR000466
InterPro IPR000469
InterPro IPR000481
InterPro IPR000482
InterPro IPR000496
InterPro IPR000499
InterPro IPR000502
InterPro IPR000503
InterPro IPR000505
InterPro IPR000586
InterPro IPR000596
InterPro IPR000610
InterPro IPR000611
InterPro IPR000621
InterPro IPR000628
InterPro IPR000654
InterPro IPR000670
InterPro IPR000681
InterPro IPR000708
InterPro IPR000725
InterPro IPR000732
InterPro IPR000735
InterPro IPR000761
InterPro IPR000810
InterPro IPR000820
InterPro IPR000826
InterPro IPR000832
InterPro IPR000848
InterPro IPR000856
InterPro IPR000913
InterPro IPR000921
InterPro IPR000929
InterPro IPR000935
InterPro IPR000986
InterPro IPR000987
InterPro IPR000995
InterPro IPR001004
InterPro IPR001013
InterPro IPR001019
InterPro IPR001053
InterPro IPR001065
InterPro IPR001068
InterPro IPR001069
InterPro IPR001105
InterPro IPR001112
InterPro IPR001115
InterPro IPR001116
InterPro IPR001168
InterPro IPR001183
InterPro IPR001184
InterPro IPR001186
InterPro IPR001224
InterPro IPR001234
InterPro IPR001244
InterPro IPR001256
InterPro IPR001274
InterPro IPR001277
InterPro IPR001350
InterPro IPR001355
InterPro IPR001358
InterPro IPR001391
InterPro IPR001397
InterPro IPR001402
InterPro IPR001408
InterPro IPR001418
InterPro IPR001420
InterPro IPR001432
InterPro IPR001435
InterPro IPR001458
InterPro IPR001481
InterPro IPR001499
InterPro IPR001504
InterPro IPR001512
InterPro IPR001513
InterPro IPR001520
InterPro IPR001521
InterPro IPR001546
InterPro IPR001551
InterPro IPR001571
InterPro IPR001644
InterPro IPR001658
InterPro IPR001671
InterPro IPR001681
InterPro IPR001718
InterPro IPR001735
InterPro IPR001740
InterPro IPR001749
InterPro IPR001758
InterPro IPR001760
InterPro IPR001770
InterPro IPR001771
InterPro IPR001786
InterPro IPR001793
InterPro IPR001817
InterPro IPR001856
InterPro IPR001883
InterPro IPR001908
InterPro IPR001923
InterPro IPR001933
InterPro IPR001946
InterPro IPR001973
InterPro IPR002002
InterPro IPR002062
InterPro IPR002074
InterPro IPR002120
InterPro IPR002122
InterPro IPR002131
InterPro IPR002147
InterPro IPR002175
InterPro IPR002206
InterPro IPR002228
InterPro IPR002230
InterPro IPR002231
InterPro IPR002232
InterPro IPR002233
InterPro IPR002235
InterPro IPR002236
InterPro IPR002237
InterPro IPR002238
InterPro IPR002239
InterPro IPR002240
InterPro IPR002258
InterPro IPR002272
InterPro IPR002273
InterPro IPR002274
InterPro IPR002275
InterPro IPR002276
InterPro IPR002277
InterPro IPR002278
InterPro IPR002279
InterPro IPR002280
InterPro IPR002282
InterPro IPR002284
InterPro IPR002285
InterPro IPR002286
InterPro IPR002455
InterPro IPR002456
InterPro IPR002457
InterPro IPR002962
InterPro IPR002975
InterPro IPR002976
InterPro IPR003287
InterPro IPR003288
InterPro IPR003289
InterPro IPR003290
InterPro IPR003291
InterPro IPR003292
InterPro IPR003334
InterPro IPR003904
InterPro IPR003905
InterPro IPR003906
InterPro IPR003907
InterPro IPR003908
InterPro IPR003909
InterPro IPR003910
InterPro IPR003980
InterPro IPR003981
InterPro IPR003982
InterPro IPR003983
InterPro IPR003984
InterPro IPR003985
InterPro IPR003986
InterPro IPR004059
InterPro IPR004060
InterPro IPR004061
InterPro IPR004062
InterPro IPR004063
InterPro IPR004064
InterPro IPR004065
InterPro IPR004066
InterPro IPR004067
InterPro IPR004068
InterPro IPR004069
InterPro IPR004070
InterPro IPR004071
InterPro IPR004072
InterPro IPR004073
InterPro IPR005382
InterPro IPR005385
InterPro IPR005386
InterPro IPR005387
InterPro IPR005388
InterPro IPR005389
InterPro IPR005390
InterPro IPR005391
InterPro IPR005392
InterPro IPR005393
InterPro IPR005394
InterPro IPR005395
InterPro IPR005396
InterPro IPR005397
InterPro IPR005466
InterPro IPR006030
InterPro IPR007960
InterPro IPR008078
InterPro IPR008102
InterPro IPR008109
InterPro IPR008361
InterPro IPR008362
InterPro IPR008365
InterPro IPR009106
InterPro IPR009126
InterPro IPR009132
InterPro IPR009133
InterPro IPR009150
InterPro IPR011500
InterPro IPR013312
InterPro IPR013313
InterPro IPR015898
InterPro IPR017978
InterPro IPR017979
InterPro IPR017983
InterPro IPR019336
InterPro IPR022335
InterPro IPR022347
InterPro IPR022348
InterPro IPR026221
InterPro IPR026228
InterPro IPR026230
InterPro IPR026232
InterPro IPR026233
InterPro IPR026234
InterPro IPR027294
InterPro IPR027336
InterPro IPR027338
InterPro IPR027341
InterPro IPR027344
InterPro IPR027345
InterPro IPR027347
InterPro IPR027348
InterPro IPR027349
InterPro IPR027425
InterPro IPR027459
InterPro IPR027669
InterPro IPR027676
InterPro IPR027677
InterPro IPR027809
InterPro IPR027982
InterPro IPR027983
InterPro IPR028016
InterPro IPR028017
UniProtKB-KW G-protein coupled receptor

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007186:
Relationship To GO:0007186 Child Term Child Term Name
Is a GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion
Is a GO:0000757 signal transduction involved in conjugation with mutual genetic exchange
Is a GO:0042699 follicle-stimulating hormone signaling pathway
Is a GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Is a GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
Is a GO:0007210 serotonin receptor signaling pathway
Is a GO:0007211 octopamine or tyramine signaling pathway
Is a GO:0007212 dopamine receptor signaling pathway
Is a GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
Is a GO:0007214 gamma-aminobutyric acid signaling pathway
Is a GO:0007217 tachykinin receptor signaling pathway
Is a GO:0007218 neuropeptide signaling pathway
Part of GO:0031684 heterotrimeric G-protein complex cycle
Part of GO:0004930 G-protein coupled receptor activity
Is a GO:0071875 adrenergic receptor signaling pathway
Is a GO:0001789 G-protein coupled receptor signaling pathway, coupled to S1P second messenger
Is a GO:0031583 phospholipase D-activating G-protein coupled receptor signaling pathway
Is a GO:0031989 bombesin receptor signaling pathway
Is a GO:0016056 rhodopsin mediated signaling pathway
Regulates GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
Is a GO:0007216 G-protein coupled glutamate receptor signaling pathway
Negatively regulates GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
Positively regulates GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
Is a GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
Is a GO:0035588 G-protein coupled purinergic receptor signaling pathway
Is a GO:0035625 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
Is a GO:0060183 apelin receptor signaling pathway
Is a GO:0042700 luteinizing hormone signaling pathway
Is a GO:0070493 thrombin receptor signaling pathway
Is a GO:0038178 complement component C5a signaling pathway
Is a GO:0038035 G-protein coupled receptor signaling in absence of ligand
Is a GO:0038166 angiotensin-activated signaling pathway
Is a GO:0038194 thyroid-stimulating hormone signaling pathway
Is a GO:0097646 calcitonin family receptor signaling pathway
Is a GO:0030845 phospholipase C-inhibiting G-protein coupled receptor signaling pathway
Is a GO:0038188 cholecystokinin signaling pathway
Is a GO:0038192 gastric inhibitory peptide signaling pathway
Is a GO:0038193 thromboxane A2 signaling pathway
Is a GO:0038003 opioid receptor signaling pathway
Is a GO:0038042 dimeric G-protein coupled receptor signaling pathway
Is a GO:0003376 sphingosine-1-phosphate signaling pathway
Is a GO:0038169 somatostatin receptor signaling pathway
Is a GO:0038171 cannabinoid signaling pathway
Is a GO:0086100 endothelin receptor signaling pathway
Is a GO:0086103 G-protein coupled receptor signaling pathway involved in heart process

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007186. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007186 based on the entire annotation set Co-occurrence statistics for GO:0007186 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-06-14 Deleted SYNONYM G-protein coupled receptor protein signalling pathway
2012-06-14 Added SYNONYM GPCR signaling pathway
2012-06-14 Added SYNONYM GPCR signalling pathway
2012-06-14 Deleted SYNONYM GPCR protein signaling pathway
2012-06-14 Deleted SYNONYM GPCR protein signalling pathway
2012-06-14 Added SYNONYM G-protein coupled receptor signalling pathway
2012-01-18 Added DEFINITION A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 Deleted DEFINITION Any series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
2011-11-26 Added DEFINITION Any series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
2011-11-26 Deleted DEFINITION Any series of molecular signals initiated by an extracellular signal combining with a receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
2011-10-24 Updated TERM G-protein coupled receptor signaling pathway
2011-10-24 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2011-10-24 Added DEFINITION Any series of molecular signals initiated by an extracellular signal combining with a receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
2011-10-24 Added SYNONYM G-protein coupled receptor protein signaling pathway
2008-10-21 Added SYNONYM G-protein coupled receptor protein signal transduction
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2008-04-01 Updated RELATION is a GO:0007166 (cell surface receptor signaling pathway)
2007-08-09 Added SYNONYM G protein coupled receptor protein signaling pathway
2007-08-09 Added SYNONYM G protein coupled receptor protein signalling pathway
2007-08-09 Added SYNONYM G-protein coupled receptor protein signalling pathway
2007-08-09 Added SYNONYM G-protein-coupled receptor protein signaling pathway
2007-08-09 Added SYNONYM G-protein-coupled receptor protein signalling pathway
2007-08-09 Added SYNONYM GPCR protein signaling pathway
2007-08-09 Added SYNONYM GPCR protein signalling pathway
2007-08-09 Deleted SYNONYM G protein coupled receptor protein signaling pathway
2007-08-09 Deleted SYNONYM G protein coupled receptor protein signalling pathway
2007-08-09 Deleted SYNONYM G-protein coupled receptor protein signalling pathway
2007-08-09 Deleted SYNONYM G-protein-coupled receptor protein signaling pathway
2007-08-09 Deleted SYNONYM G-protein-coupled receptor protein signalling pathway
2007-08-09 Deleted SYNONYM GPCR protein signaling pathway
2007-08-09 Deleted SYNONYM GPCR protein signalling pathway
2005-06-27 Added SYNONYM G protein coupled receptor protein signaling pathway
2005-06-27 Added SYNONYM G protein coupled receptor protein signalling pathway
2005-06-27 Added SYNONYM G-protein-coupled receptor protein signaling pathway
2005-06-27 Added SYNONYM G-protein-coupled receptor protein signalling pathway
2005-06-27 Added SYNONYM GPCR protein signaling pathway
2005-06-27 Added SYNONYM GPCR protein signalling pathway
2004-06-24 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2004-04-19 Added SYNONYM G-protein coupled receptor protein signalling pathway
2004-04-16 Deleted SYNONYM G-protein coupled receptor protein signalling pathway
2003-11-13 Added SYNONYM G-protein coupled receptor protein signalling pathway
2002-02-06 Updated TERM G-protein coupled receptor protein signaling pathway
2001-04-03 Updated TERM G-protein coupled receptor protein signaling pathway
2001-03-30 Added TERM G-protein coupled receptor protein signaling pathway

Term

Timestamp Action Category Detail
2011-10-24 Updated TERM G-protein coupled receptor signaling pathway
2002-02-06 Updated TERM G-protein coupled receptor protein signaling pathway
2001-04-03 Updated TERM G-protein coupled receptor protein signaling pathway
2001-03-30 Added TERM G-protein coupled receptor protein signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-06-14 Deleted SYNONYM G-protein coupled receptor protein signalling pathway
2012-06-14 Added SYNONYM GPCR signaling pathway
2012-06-14 Added SYNONYM GPCR signalling pathway
2012-06-14 Deleted SYNONYM GPCR protein signaling pathway
2012-06-14 Deleted SYNONYM GPCR protein signalling pathway
2012-06-14 Added SYNONYM G-protein coupled receptor signalling pathway
2012-01-18 Added DEFINITION A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 Deleted DEFINITION Any series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
2011-11-26 Added DEFINITION Any series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
2011-11-26 Deleted DEFINITION Any series of molecular signals initiated by an extracellular signal combining with a receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
2011-10-24 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2011-10-24 Added DEFINITION Any series of molecular signals initiated by an extracellular signal combining with a receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
2011-10-24 Added SYNONYM G-protein coupled receptor protein signaling pathway
2008-10-21 Added SYNONYM G-protein coupled receptor protein signal transduction
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2007-08-09 Added SYNONYM G protein coupled receptor protein signaling pathway
2007-08-09 Added SYNONYM G protein coupled receptor protein signalling pathway
2007-08-09 Added SYNONYM G-protein coupled receptor protein signalling pathway
2007-08-09 Added SYNONYM G-protein-coupled receptor protein signaling pathway
2007-08-09 Added SYNONYM G-protein-coupled receptor protein signalling pathway
2007-08-09 Added SYNONYM GPCR protein signaling pathway
2007-08-09 Added SYNONYM GPCR protein signalling pathway
2007-08-09 Deleted SYNONYM G protein coupled receptor protein signaling pathway
2007-08-09 Deleted SYNONYM G protein coupled receptor protein signalling pathway
2007-08-09 Deleted SYNONYM G-protein coupled receptor protein signalling pathway
2007-08-09 Deleted SYNONYM G-protein-coupled receptor protein signaling pathway
2007-08-09 Deleted SYNONYM G-protein-coupled receptor protein signalling pathway
2007-08-09 Deleted SYNONYM GPCR protein signaling pathway
2007-08-09 Deleted SYNONYM GPCR protein signalling pathway
2005-06-27 Added SYNONYM G protein coupled receptor protein signaling pathway
2005-06-27 Added SYNONYM G protein coupled receptor protein signalling pathway
2005-06-27 Added SYNONYM G-protein-coupled receptor protein signaling pathway
2005-06-27 Added SYNONYM G-protein-coupled receptor protein signalling pathway
2005-06-27 Added SYNONYM GPCR protein signaling pathway
2005-06-27 Added SYNONYM GPCR protein signalling pathway
2004-06-24 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
2004-04-19 Added SYNONYM G-protein coupled receptor protein signalling pathway
2004-04-16 Deleted SYNONYM G-protein coupled receptor protein signalling pathway
2003-11-13 Added SYNONYM G-protein coupled receptor protein signalling pathway

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0007166 (cell surface receptor signaling pathway)
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