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GO:0007175 negative regulation of epidermal growth factor-activated receptor activity

Term Information

ID GO:0007175
Name negative regulation of epidermal growth factor-activated receptor activity
Ontology Biological Process
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.
Secondary IDs GO:0007177
GONUTS GO:0007175 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact negative regulation of EGFR activity
exact negative regulation of EGF receptor activity
exact downregulation of epidermal growth factor receptor activity
exact down-regulation of epidermal growth factor receptor activity
exact down regulation of epidermal growth factor receptor activity
exact EGF receptor downregulation
exact negative regulation of epidermal growth factor receptor activity
narrow inhibition of epidermal growth factor receptor activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR028416

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0005156 epidermal growth factor receptor inhibiting ligand activity CONSIDER GO:0007175

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007175:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007175. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007175 based on the entire annotation set Co-occurrence statistics for GO:0007175 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-08-18 Updated TERM negative regulation of epidermal growth factor-activated receptor activity
2011-08-18 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of EGF receptor activity.
2011-08-18 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.
2011-08-18 Added SYNONYM negative regulation of epidermal growth factor receptor activity
2010-12-05 Added RELATION is a GO:2000272 (negative regulation of receptor activity)
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of EGF receptor activity.
2010-06-15 Added RELATION negatively regulates GO:0005006 (epidermal growth factor-activated receptor activity)
2010-06-14 Deleted RELATION negatively regulates GO:0005006 (epidermal growth factor-activated receptor activity)
2010-06-09 Updated TERM negative regulation of epidermal growth factor receptor activity
2010-06-08 Added RELATION negatively regulates GO:0005006 (epidermal growth factor-activated receptor activity)
2010-06-08 Updated TERM negative regulation of epidermal growth factor receptor activity
2010-06-04 Deleted RELATION is a GO:0006469 (negative regulation of protein kinase activity)
2010-04-30 Added RELATION is a GO:0061099 (negative regulation of protein tyrosine kinase activity)
2009-02-25 Updated TERM negative regulation of epidermal growth factor receptor activity
2009-02-25 Deleted RELATION negatively regulates GO:0005006 (epidermal growth factor-activated receptor activity)
2009-02-22 Added RELATION negatively regulates GO:0005006 (epidermal growth factor-activated receptor activity)
2009-02-22 Updated TERM negative regulation of epidermal growth factor receptor activity
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity.
2008-04-01 Updated RELATION is a GO:0006469 (negative regulation of protein kinase activity)
2008-04-01 Updated RELATION is a GO:0007176 (regulation of epidermal growth factor-activated receptor activity)
2008-04-01 Updated RELATION is a GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway)
2007-08-09 Added SYNONYM EGF receptor downregulation
2007-08-09 Added SYNONYM down regulation of epidermal growth factor receptor activity
2007-08-09 Added SYNONYM down-regulation of epidermal growth factor receptor activity
2007-08-09 Added SYNONYM downregulation of epidermal growth factor receptor activity
2007-08-09 Added SYNONYM inhibition of epidermal growth factor receptor activity
2007-08-09 Added SYNONYM negative regulation of EGF receptor activity
2007-08-09 Added SYNONYM negative regulation of EGFR activity
2007-08-09 Deleted SYNONYM down regulation of epidermal growth factor receptor activity
2007-08-09 Deleted SYNONYM down-regulation of epidermal growth factor receptor activity
2007-08-09 Deleted SYNONYM downregulation of epidermal growth factor receptor activity
2007-08-09 Deleted SYNONYM inhibition of epidermal growth factor receptor activity
2007-08-09 Deleted SYNONYM EGF receptor downregulation
2007-08-09 Deleted SYNONYM negative regulation of EGF receptor activity
2007-08-09 Deleted SYNONYM negative regulation of EGFR activity
2007-02-23 Added SYNONYM down regulation of epidermal growth factor receptor activity
2007-02-23 Added SYNONYM down-regulation of epidermal growth factor receptor activity
2007-02-23 Added SYNONYM downregulation of epidermal growth factor receptor activity
2007-02-23 Added SYNONYM inhibition of epidermal growth factor receptor activity
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of EGF receptor activity.
2004-11-09 Added SYNONYM negative regulation of EGFR activity
2004-04-19 Added SYNONYM EGF receptor downregulation
2004-04-19 Added SYNONYM negative regulation of EGF receptor activity
2004-04-16 Deleted SYNONYM EGF receptor downregulation
2004-04-16 Deleted SYNONYM negative regulation of EGF receptor activity
2004-02-12 Added SYNONYM negative regulation of EGF receptor activity
2004-02-12 Updated TERM negative regulation of epidermal growth factor receptor activity
2002-11-27 Added DEFINITION Any process that stops, prevents or reduces the rate of EGF receptor activity.
2002-08-20 Updated TERM negative regulation of EGF receptor activity
2002-07-17 Added SECONDARY GO:0007177 (EGF receptor down regulation)
2002-07-17 Added SYNONYM EGF receptor downregulation
2002-07-15 Updated TERM negative regulation of EGF receptor
2002-02-06 Updated TERM EGF receptor inhibition
2001-04-03 Updated TERM EGF receptor inhibition
2001-03-30 Added TERM EGF receptor inhibition

Term

Timestamp Action Category Detail
2011-08-18 Updated TERM negative regulation of epidermal growth factor-activated receptor activity
2010-06-09 Updated TERM negative regulation of epidermal growth factor receptor activity
2010-06-08 Updated TERM negative regulation of epidermal growth factor receptor activity
2009-02-25 Updated TERM negative regulation of epidermal growth factor receptor activity
2009-02-22 Updated TERM negative regulation of epidermal growth factor receptor activity
2004-02-12 Updated TERM negative regulation of epidermal growth factor receptor activity
2002-08-20 Updated TERM negative regulation of EGF receptor activity
2002-07-15 Updated TERM negative regulation of EGF receptor
2002-02-06 Updated TERM EGF receptor inhibition
2001-04-03 Updated TERM EGF receptor inhibition
2001-03-30 Added TERM EGF receptor inhibition

Definition/synonyms

Timestamp Action Category Detail
2011-08-18 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of EGF receptor activity.
2011-08-18 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.
2011-08-18 Added SYNONYM negative regulation of epidermal growth factor receptor activity
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of EGF receptor activity.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity.
2007-08-09 Added SYNONYM EGF receptor downregulation
2007-08-09 Added SYNONYM down regulation of epidermal growth factor receptor activity
2007-08-09 Added SYNONYM down-regulation of epidermal growth factor receptor activity
2007-08-09 Added SYNONYM downregulation of epidermal growth factor receptor activity
2007-08-09 Added SYNONYM inhibition of epidermal growth factor receptor activity
2007-08-09 Added SYNONYM negative regulation of EGF receptor activity
2007-08-09 Added SYNONYM negative regulation of EGFR activity
2007-08-09 Deleted SYNONYM down regulation of epidermal growth factor receptor activity
2007-08-09 Deleted SYNONYM down-regulation of epidermal growth factor receptor activity
2007-08-09 Deleted SYNONYM downregulation of epidermal growth factor receptor activity
2007-08-09 Deleted SYNONYM inhibition of epidermal growth factor receptor activity
2007-08-09 Deleted SYNONYM EGF receptor downregulation
2007-08-09 Deleted SYNONYM negative regulation of EGF receptor activity
2007-08-09 Deleted SYNONYM negative regulation of EGFR activity
2007-02-23 Added SYNONYM down regulation of epidermal growth factor receptor activity
2007-02-23 Added SYNONYM down-regulation of epidermal growth factor receptor activity
2007-02-23 Added SYNONYM downregulation of epidermal growth factor receptor activity
2007-02-23 Added SYNONYM inhibition of epidermal growth factor receptor activity
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of EGF receptor activity.
2004-11-09 Added SYNONYM negative regulation of EGFR activity
2004-04-19 Added SYNONYM EGF receptor downregulation
2004-04-19 Added SYNONYM negative regulation of EGF receptor activity
2004-04-16 Deleted SYNONYM EGF receptor downregulation
2004-04-16 Deleted SYNONYM negative regulation of EGF receptor activity
2004-02-12 Added SYNONYM negative regulation of EGF receptor activity
2002-11-27 Added DEFINITION Any process that stops, prevents or reduces the rate of EGF receptor activity.
2002-07-17 Added SYNONYM EGF receptor downregulation

Relationships

Timestamp Action Category Detail
2010-12-05 Added RELATION is a GO:2000272 (negative regulation of receptor activity)
2010-06-15 Added RELATION negatively regulates GO:0005006 (epidermal growth factor-activated receptor activity)
2010-06-14 Deleted RELATION negatively regulates GO:0005006 (epidermal growth factor-activated receptor activity)
2010-06-08 Added RELATION negatively regulates GO:0005006 (epidermal growth factor-activated receptor activity)
2010-06-04 Deleted RELATION is a GO:0006469 (negative regulation of protein kinase activity)
2010-04-30 Added RELATION is a GO:0061099 (negative regulation of protein tyrosine kinase activity)
2009-02-25 Deleted RELATION negatively regulates GO:0005006 (epidermal growth factor-activated receptor activity)
2009-02-22 Added RELATION negatively regulates GO:0005006 (epidermal growth factor-activated receptor activity)
2008-04-01 Updated RELATION is a GO:0006469 (negative regulation of protein kinase activity)
2008-04-01 Updated RELATION is a GO:0007176 (regulation of epidermal growth factor-activated receptor activity)
2008-04-01 Updated RELATION is a GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway)

Other

Timestamp Action Category Detail
2002-07-17 Added SECONDARY GO:0007177 (EGF receptor down regulation)
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