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GO:0007173 epidermal growth factor receptor signaling pathway

Term Information

ID GO:0007173
Name epidermal growth factor receptor signaling pathway
Ontology Biological Process
Definition A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
GONUTS GO:0007173 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact EGF receptor signalling pathway
exact EGF receptor signaling pathway
exact ERBB1 signaling pathway
exact receptor tyrosine-protein kinase erbB-1 signaling pathway
exact EGFR signaling pathway
exact epidermal growth factor receptor signalling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR028420

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007173:
Relationship To GO:0007173 Child Term Child Term Name
Part of GO:0005006 epidermal growth factor-activated receptor activity
Is a GO:0008314 gurken signaling pathway
Part of GO:0060724 coreceptor activity involved in epidermal growth factor receptor signaling pathway
Positively regulates GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
Is a GO:0060507 epidermal growth factor receptor signaling pathway involved in lung development
Is a GO:0022026 epidermal growth factor signaling pathway involved in forebrain neuron fate commitment
Regulates GO:0042058 regulation of epidermal growth factor receptor signaling pathway
Negatively regulates GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Is a GO:0038167 epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity
Is a GO:0038134 ERBB2-EGFR signaling pathway
Is a GO:0038137 ERBB4-EGFR signaling pathway
Is a GO:0038029 epidermal growth factor receptor signaling pathway via MAPK cascade

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007173. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007173 based on the entire annotation set Co-occurrence statistics for GO:0007173 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-04-01 Added SYNONYM receptor tyrosine-protein kinase erbB-1 signaling pathway
2012-04-01 Added RELATION is a GO:0038127 (ERBB signaling pathway)
2012-04-01 Deleted RELATION is a GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
2012-04-01 Added SYNONYM ERBB1 signaling pathway
2012-04-01 Deleted DEFINITION The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
2012-04-01 Added DEFINITION A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
2008-04-01 Updated RELATION is a GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
2007-08-09 Added SYNONYM EGF receptor signaling pathway
2007-08-09 Added SYNONYM EGF receptor signalling pathway
2007-08-09 Added SYNONYM EGFR signaling pathway
2007-08-09 Added SYNONYM epidermal growth factor receptor signalling pathway
2007-08-09 Deleted SYNONYM EGF receptor signaling pathway
2007-08-09 Deleted SYNONYM EGF receptor signalling pathway
2007-08-09 Deleted SYNONYM EGFR signaling pathway
2007-08-09 Deleted SYNONYM epidermal growth factor receptor signalling pathway
2004-11-09 Added SYNONYM EGFR signaling pathway
2004-10-08 Added SYNONYM epidermal growth factor receptor signalling pathway
2004-04-19 Added SYNONYM EGF receptor signaling pathway
2004-04-19 Added SYNONYM EGF receptor signalling pathway
2004-04-16 Deleted SYNONYM EGF receptor signaling pathway
2004-04-16 Deleted SYNONYM EGF receptor signalling pathway
2004-02-12 Added SYNONYM EGF receptor signaling pathway
2004-02-12 Updated TERM epidermal growth factor receptor signaling pathway
2003-11-13 Added SYNONYM EGF receptor signalling pathway
2002-11-27 Added DEFINITION The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
2002-02-06 Updated TERM EGF receptor signaling pathway
2001-04-03 Updated TERM EGF receptor signaling pathway
2001-03-30 Added TERM EGF receptor signaling pathway

Term

Timestamp Action Category Detail
2004-02-12 Updated TERM epidermal growth factor receptor signaling pathway
2002-02-06 Updated TERM EGF receptor signaling pathway
2001-04-03 Updated TERM EGF receptor signaling pathway
2001-03-30 Added TERM EGF receptor signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-04-01 Added SYNONYM receptor tyrosine-protein kinase erbB-1 signaling pathway
2012-04-01 Added SYNONYM ERBB1 signaling pathway
2012-04-01 Deleted DEFINITION The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
2012-04-01 Added DEFINITION A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
2007-08-09 Added SYNONYM EGF receptor signaling pathway
2007-08-09 Added SYNONYM EGF receptor signalling pathway
2007-08-09 Added SYNONYM EGFR signaling pathway
2007-08-09 Added SYNONYM epidermal growth factor receptor signalling pathway
2007-08-09 Deleted SYNONYM EGF receptor signaling pathway
2007-08-09 Deleted SYNONYM EGF receptor signalling pathway
2007-08-09 Deleted SYNONYM EGFR signaling pathway
2007-08-09 Deleted SYNONYM epidermal growth factor receptor signalling pathway
2004-11-09 Added SYNONYM EGFR signaling pathway
2004-10-08 Added SYNONYM epidermal growth factor receptor signalling pathway
2004-04-19 Added SYNONYM EGF receptor signaling pathway
2004-04-19 Added SYNONYM EGF receptor signalling pathway
2004-04-16 Deleted SYNONYM EGF receptor signaling pathway
2004-04-16 Deleted SYNONYM EGF receptor signalling pathway
2004-02-12 Added SYNONYM EGF receptor signaling pathway
2003-11-13 Added SYNONYM EGF receptor signalling pathway
2002-11-27 Added DEFINITION The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.

Relationships

Timestamp Action Category Detail
2012-04-01 Added RELATION is a GO:0038127 (ERBB signaling pathway)
2012-04-01 Deleted RELATION is a GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
2008-04-01 Updated RELATION is a GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
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