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GO:0007166 cell surface receptor signaling pathway

Term Information

ID GO:0007166
Name cell surface receptor signaling pathway
Ontology Biological Process
Definition A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
GONUTS GO:0007166 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact cell surface receptor linked signal transduction
exact cell surface receptor linked signalling pathway
exact cell surface receptor linked signaling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR000539
InterPro IPR003110
InterPro IPR003153
InterPro IPR017981

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007166:
Relationship To GO:0007166 Child Term Child Term Name
Is a GO:0007167 enzyme linked receptor protein signaling pathway
Is a GO:0007186 G-protein coupled receptor signaling pathway
Is a GO:0007219 Notch signaling pathway
Is a GO:0007224 smoothened signaling pathway
Is a GO:0007229 integrin-mediated signaling pathway
Is a GO:0031663 lipopolysaccharide-mediated signaling pathway
Is a GO:0008063 Toll signaling pathway
Is a GO:0016055 Wnt signaling pathway
Is a GO:0007215 glutamate receptor signaling pathway
Is a GO:0061311 cell surface receptor signaling pathway involved in heart development
Is a GO:0033626 positive regulation of integrin activation by cell surface receptor linked signal transduction
Is a GO:0035587 purinergic receptor signaling pathway
Is a GO:0071526 semaphorin-plexin signaling pathway
Is a GO:0035385 Roundabout signaling pathway
Is a GO:0038189 neuropilin signaling pathway
Is a GO:0019221 cytokine-mediated signaling pathway
Is a GO:0023035 CD40 signaling pathway
Is a GO:0061057 peptidoglycan recognition protein signaling pathway
Is a GO:0002768 immune response-regulating cell surface receptor signaling pathway
Is a GO:0097191 extrinsic apoptotic signaling pathway
Is a GO:0038065 collagen-activated signaling pathway
Is a GO:0038007 netrin-activated signaling pathway
Is a GO:0038184 cell surface bile acid receptor signaling pathway
Is a GO:0038026 reelin-mediated signaling pathway
Is a GO:0038027 apolipoprotein A-I-mediated signaling pathway
Is a GO:0038195 urokinase plasminogen activator signaling pathway
Is a GO:1990262 anti-Mullerian hormone signaling pathway
Is a GO:0038179 neurotrophin signaling pathway
Is a GO:0036337 Fas signaling pathway

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007166. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007166 based on the entire annotation set Co-occurrence statistics for GO:0007166 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-14 Updated TERM cell surface receptor signaling pathway
2012-01-14 Added SYNONYM cell surface receptor linked signaling pathway
2011-11-26 Added DEFINITION A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2011-11-26 Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2011-01-16 Added RELATION is a GO:0007165 (signal transduction)
2011-01-16 Deleted RELATION is a GO:0023033 (signaling pathway)
2010-11-17 Added SYNONYM cell surface receptor linked signalling pathway
2010-02-20 Added RELATION is a GO:0023033 (signaling pathway)
2010-02-20 Deleted RELATION is a GO:0007165 (signal transduction)
2010-02-20 Added SYNONYM cell surface receptor linked signal transduction
2010-02-20 Updated TERM cell surface receptor linked signaling pathway
2008-05-13 Added DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2008-05-12 Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2008-04-01 Updated RELATION is a GO:0007165 (signal transduction)
2004-07-25 Updated DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2004-02-12 Updated DEFINITION Any pathway of signal transduction initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2004-02-12 Updated DEFINITION Any pathway of signal transduction initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2002-11-27 Added DEFINITION Any pathway of signal transduction initiated by binding of a ligand to an extracellular ligand to a receptor on the surface of the target cell.
2002-02-06 Updated TERM cell surface receptor linked signal transduction
2001-04-03 Updated TERM cell surface receptor linked signal transduction
2001-03-30 Added TERM cell surface receptor linked signal transduction

Term

Timestamp Action Category Detail
2012-01-14 Updated TERM cell surface receptor signaling pathway
2010-02-20 Updated TERM cell surface receptor linked signaling pathway
2002-02-06 Updated TERM cell surface receptor linked signal transduction
2001-04-03 Updated TERM cell surface receptor linked signal transduction
2001-03-30 Added TERM cell surface receptor linked signal transduction

Definition/synonyms

Timestamp Action Category Detail
2012-01-14 Added SYNONYM cell surface receptor linked signaling pathway
2011-11-26 Added DEFINITION A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2011-11-26 Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2010-11-17 Added SYNONYM cell surface receptor linked signalling pathway
2010-02-20 Added SYNONYM cell surface receptor linked signal transduction
2008-05-13 Added DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2008-05-12 Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2004-07-25 Updated DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2004-02-12 Updated DEFINITION Any pathway of signal transduction initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2004-02-12 Updated DEFINITION Any pathway of signal transduction initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2002-11-27 Added DEFINITION Any pathway of signal transduction initiated by binding of a ligand to an extracellular ligand to a receptor on the surface of the target cell.

Relationships

Timestamp Action Category Detail
2011-01-16 Added RELATION is a GO:0007165 (signal transduction)
2011-01-16 Deleted RELATION is a GO:0023033 (signaling pathway)
2010-02-20 Added RELATION is a GO:0023033 (signaling pathway)
2010-02-20 Deleted RELATION is a GO:0007165 (signal transduction)
2008-04-01 Updated RELATION is a GO:0007165 (signal transduction)
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