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GO:0035103 sterol regulatory element binding protein cleavage

Term Information

ID GO:0035103
Name sterol regulatory element binding protein cleavage
Ontology Biological Process
Definition The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids.
PMID:12923525
Secondary IDs GO:0006992
GONUTS GO:0035103 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact SREBP cleavage
narrow sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway
exact sterol depletion response, SREBP cleavage

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to transcription processesLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
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Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0035103:
Relationship To GO:0035103 Child Term Child Term Name
Regulates GO:1901308 regulation of sterol regulatory element binding protein cleavage
Negatively regulates GO:1901309 negative regulation of sterol regulatory element binding protein cleavage
Positively regulates GO:1901310 positive regulation of sterol regulatory element binding protein cleavage

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0035103. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0035103 based on the entire annotation set Co-occurrence statistics for GO:0035103 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-10-17 Added SECONDARY GO:0006992 (sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway)
2012-10-17 Added DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids.
2012-10-17 Deleted DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids.
2012-10-17 Added SYNONYM sterol depletion response, SREBP cleavage
2012-10-17 Added SYNONYM sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway
2011-08-21 Added RELATION is a GO:0016485 (protein processing)
2011-08-21 Deleted RELATION is a GO:0051605 (protein maturation by peptide bond cleavage)
2010-03-25 Added RELATION is a GO:0044267 (cellular protein metabolic process)
2009-05-03 Added RELATION is a GO:0051605 (protein maturation by peptide bond cleavage)
2009-05-03 Deleted RELATION is a GO:0016485 (protein processing)
2008-05-13 Added DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids.
2008-05-12 Deleted DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids.
2008-04-01 Updated RELATION part of GO:0032933 (SREBP signaling pathway)
2008-04-01 Updated RELATION is a GO:0016485 (protein processing)
2007-08-09 Added SYNONYM SREBP cleavage
2007-08-09 Deleted SYNONYM SREBP cleavage
2007-02-23 Updated TERM sterol regulatory element binding protein cleavage
2007-02-16 Updated DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids.
2004-04-19 Added SYNONYM SREBP cleavage
2004-04-16 Deleted SYNONYM SREBP cleavage
2004-03-02 Added SYNONYM SREBP cleavage
2004-03-02 Added DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding-protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes.
2004-03-02 Added TERM sterol regulatory element binding-protein cleavage

Term

Timestamp Action Category Detail
2007-02-23 Updated TERM sterol regulatory element binding protein cleavage
2004-03-02 Added TERM sterol regulatory element binding-protein cleavage

Definition/synonyms

Timestamp Action Category Detail
2012-10-17 Added DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids.
2012-10-17 Deleted DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids.
2012-10-17 Added SYNONYM sterol depletion response, SREBP cleavage
2012-10-17 Added SYNONYM sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway
2008-05-13 Added DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids.
2008-05-12 Deleted DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids.
2007-08-09 Added SYNONYM SREBP cleavage
2007-08-09 Deleted SYNONYM SREBP cleavage
2007-02-16 Updated DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids.
2004-04-19 Added SYNONYM SREBP cleavage
2004-04-16 Deleted SYNONYM SREBP cleavage
2004-03-02 Added SYNONYM SREBP cleavage
2004-03-02 Added DEFINITION The proteolytic release of a transcriptionally active sterol regulatory element binding-protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes.

Relationships

Timestamp Action Category Detail
2011-08-21 Added RELATION is a GO:0016485 (protein processing)
2011-08-21 Deleted RELATION is a GO:0051605 (protein maturation by peptide bond cleavage)
2010-03-25 Added RELATION is a GO:0044267 (cellular protein metabolic process)
2009-05-03 Added RELATION is a GO:0051605 (protein maturation by peptide bond cleavage)
2009-05-03 Deleted RELATION is a GO:0016485 (protein processing)
2008-04-01 Updated RELATION part of GO:0032933 (SREBP signaling pathway)
2008-04-01 Updated RELATION is a GO:0016485 (protein processing)

Other

Timestamp Action Category Detail
2012-10-17 Added SECONDARY GO:0006992 (sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway)
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