spacer

GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

Term Information

ID GO:0006978
Name DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Ontology Biological Process
Definition A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
PMID:10967424
GONUTS GO:0006978 Wiki Page

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006978:
Relationship To GO:0006978 Child Term Child Term Name
Regulates GO:1902162 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Negatively regulates GO:1902163 negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Positively regulates GO:1902164 positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006978. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006978 based on the entire annotation set Co-occurrence statistics for GO:0006978 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
2008-05-12 Deleted DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
2008-04-01 Updated RELATION is a GO:0042772 (DNA damage response, signal transduction resulting in transcription)
2008-04-01 Updated RELATION is a GO:0030330 (DNA damage response, signal transduction by p53 class mediator)
2005-10-14 Updated DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
2003-07-01 Updated DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the perception of DNA damage.
2003-06-21 Updated TERM DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
2003-06-21 Added DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the perception of DNA damage.
2002-02-06 Updated TERM DNA damage response, induction of cyclin-dependent protein kinase inhibitor p21
2001-04-03 Updated TERM DNA damage response, induction of cyclin-dependent protein kinase inhibitor p21
2001-03-30 Added TERM DNA damage response, induction of cyclin-dependent protein kinase inhibitor p21

Term

Timestamp Action Category Detail
2003-06-21 Updated TERM DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
2002-02-06 Updated TERM DNA damage response, induction of cyclin-dependent protein kinase inhibitor p21
2001-04-03 Updated TERM DNA damage response, induction of cyclin-dependent protein kinase inhibitor p21
2001-03-30 Added TERM DNA damage response, induction of cyclin-dependent protein kinase inhibitor p21

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
2008-05-12 Deleted DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
2005-10-14 Updated DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
2003-07-01 Updated DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the perception of DNA damage.
2003-06-21 Added DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the perception of DNA damage.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0042772 (DNA damage response, signal transduction resulting in transcription)
2008-04-01 Updated RELATION is a GO:0030330 (DNA damage response, signal transduction by p53 class mediator)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
20ms