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GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Term Information

ID GO:0006977
Name DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Ontology Biological Process
Definition A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
GONUTS GO:0006977 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact positive regulation of cell cycle arrest by p53-mediated DNA damage response

GO Discussions

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Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0000278 mitotic cell cycle only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006977:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006977. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006977 based on the entire annotation set Co-occurrence statistics for GO:0006977 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-12-10 Added RELATION is a GO:0072431 (signal transduction involved in mitotic G1 DNA damage checkpoint)
2010-12-10 Deleted RELATION part of GO:0031571 (mitotic G1 DNA damage checkpoint)
2009-11-24 Added SYNONYM positive regulation of cell cycle arrest by p53-mediated DNA damage response
2009-11-24 Added RELATION is a GO:0071158 (positive regulation of cell cycle arrest)
2008-05-13 Added DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
2008-05-12 Deleted DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
2008-04-01 Updated RELATION part of GO:0031571 (mitotic G1 DNA damage checkpoint)
2008-04-01 Updated RELATION is a GO:0030330 (DNA damage response, signal transduction by p53 class mediator)
2005-10-14 Updated DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
2003-06-21 Updated TERM DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2003-06-21 Added DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the perception of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
2002-02-06 Updated TERM DNA damage response, induction of cell arrest by p53
2001-04-03 Updated TERM DNA damage response, induction of cell arrest by p53
2001-03-30 Added TERM DNA damage response, induction of cell arrest by p53

Term

Timestamp Action Category Detail
2003-06-21 Updated TERM DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2002-02-06 Updated TERM DNA damage response, induction of cell arrest by p53
2001-04-03 Updated TERM DNA damage response, induction of cell arrest by p53
2001-03-30 Added TERM DNA damage response, induction of cell arrest by p53

Definition/synonyms

Timestamp Action Category Detail
2009-11-24 Added SYNONYM positive regulation of cell cycle arrest by p53-mediated DNA damage response
2008-05-13 Added DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
2008-05-12 Deleted DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
2005-10-14 Updated DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
2003-06-21 Added DEFINITION A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the perception of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

Relationships

Timestamp Action Category Detail
2010-12-10 Added RELATION is a GO:0072431 (signal transduction involved in mitotic G1 DNA damage checkpoint)
2010-12-10 Deleted RELATION part of GO:0031571 (mitotic G1 DNA damage checkpoint)
2009-11-24 Added RELATION is a GO:0071158 (positive regulation of cell cycle arrest)
2008-04-01 Updated RELATION part of GO:0031571 (mitotic G1 DNA damage checkpoint)
2008-04-01 Updated RELATION is a GO:0030330 (DNA damage response, signal transduction by p53 class mediator)
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