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GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

Term Information

ID GO:0006977
Name DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Ontology Biological Process
Definition A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
Comment

Synonyms

Type Synonym
exact positive regulation of cell cycle arrest by p53-mediated DNA damage response

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Ancestor Chart

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Ancestor Table

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0050896 response to stimulus
GO:0009987 cellular process
GO:0006950 response to stress
GO:0007049 cell cycle
GO:0007154 cell communication
GO:0050789 regulation of biological process
GO:0000278 mitotic cell cycle
GO:0022402 cell cycle process
GO:0006974 response to DNA damage stimulus
GO:0048518 positive regulation of biological process
GO:0051716 cellular response to stimulus
GO:0007050 cell cycle arrest
GO:0050794 regulation of cellular process
GO:0033554 cellular response to stress
GO:0048522 positive regulation of cellular process
GO:0051726 regulation of cell cycle
GO:0007165 signal transduction
GO:0007242 intracellular signaling cascade
GO:0000075 cell cycle checkpoint
GO:0034984 cellular response to DNA damage stimulus
GO:0031570 DNA integrity checkpoint
GO:0007346 regulation of mitotic cell cycle
GO:0010564 regulation of cell cycle process
GO:0071156 regulation of cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint
GO:0031575 G1/S transition checkpoint
GO:0090068 positive regulation of cell cycle process
GO:0071158 positive regulation of cell cycle arrest
GO:0042770 DNA damage response, signal transduction
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0000077 DNA damage checkpoint
GO:0031571 G1 DNA damage checkpoint
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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16ms
Stand-alone
Hostnametomcat-7.ebi.ac.uk
Uptime16:38 12/10/2009
Data version2009-12-08-04-03-05
Terminal
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