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GO:0006956 complement activation

Term Information

ID GO:0006956
Name complement activation
Ontology Biological Process
Definition Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Comment This term was improved by GO_REF:0000022. It was moved.
GONUTS GO:0006956 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact complement cascade
exact complement response
related complement activity

Cross-references

Database ID
InterPro IPR001840
InterPro IPR011360
InterPro IPR024175

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0003811 complement activity CONSIDER GO:0006956
GO:0030009 complement factor H activity CONSIDER GO:0006956

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006956:
Relationship To GO:0006956 Child Term Child Term Name
Is a GO:0006957 complement activation, alternative pathway
Is a GO:0006958 complement activation, classical pathway
Is a GO:0001867 complement activation, lectin pathway
Regulates GO:0030449 regulation of complement activation
Is a GO:0001905 activation of membrane attack complex
Negatively regulates GO:0045916 negative regulation of complement activation
Positively regulates GO:0045917 positive regulation of complement activation

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006956. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006956 based on the entire annotation set Co-occurrence statistics for GO:0006956 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-03-24 Added RELATION has part GO:0097278 (complement-dependent cytotoxicity)
2010-11-24 Added RELATION is a GO:0072376 (protein activation cascade)
2010-11-24 Deleted RELATION is a GO:0002541 (activation of plasma proteins involved in acute inflammatory response)
2010-11-24 Added SYNONYM complement cascade
2008-05-16 Added DEFINITION Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
2008-05-16 Deleted DEFINITION Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
2008-05-13 Added DEFINITION Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
2008-05-12 Deleted DEFINITION Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
2008-04-01 Updated RELATION is a GO:0006959 (humoral immune response)
2008-04-01 Updated RELATION is a GO:0002541 (activation of plasma proteins involved in acute inflammatory response)
2008-04-01 Updated RELATION is a GO:0002253 (activation of immune response)
2008-04-01 Updated RELATION is a GO:0002252 (immune effector process)
2007-08-09 Added SYNONYM complement activity
2007-08-09 Added SYNONYM complement response
2007-08-09 Deleted SYNONYM complement activity
2007-08-09 Deleted SYNONYM complement response
2005-12-15 Added SYNONYM complement response
2005-11-06 Deleted SYNONYM complement factor H activity
2005-08-10 Added SYNONYM complement activity
2005-08-10 Added SYNONYM complement factor H activity
2004-04-24 Added DEFINITION Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
2002-02-06 Updated TERM complement activation
2001-04-03 Updated TERM complement activation
2001-03-30 Added TERM complement activation

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM complement activation
2001-04-03 Updated TERM complement activation
2001-03-30 Added TERM complement activation

Definition/synonyms

Timestamp Action Category Detail
2010-11-24 Added SYNONYM complement cascade
2008-05-16 Added DEFINITION Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
2008-05-16 Deleted DEFINITION Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
2008-05-13 Added DEFINITION Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
2008-05-12 Deleted DEFINITION Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
2007-08-09 Added SYNONYM complement activity
2007-08-09 Added SYNONYM complement response
2007-08-09 Deleted SYNONYM complement activity
2007-08-09 Deleted SYNONYM complement response
2005-12-15 Added SYNONYM complement response
2005-11-06 Deleted SYNONYM complement factor H activity
2005-08-10 Added SYNONYM complement activity
2005-08-10 Added SYNONYM complement factor H activity
2004-04-24 Added DEFINITION Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

Relationships

Timestamp Action Category Detail
2012-03-24 Added RELATION has part GO:0097278 (complement-dependent cytotoxicity)
2010-11-24 Added RELATION is a GO:0072376 (protein activation cascade)
2010-11-24 Deleted RELATION is a GO:0002541 (activation of plasma proteins involved in acute inflammatory response)
2008-04-01 Updated RELATION is a GO:0006959 (humoral immune response)
2008-04-01 Updated RELATION is a GO:0002541 (activation of plasma proteins involved in acute inflammatory response)
2008-04-01 Updated RELATION is a GO:0002253 (activation of immune response)
2008-04-01 Updated RELATION is a GO:0002252 (immune effector process)
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