spacer

GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process

Term Information

ID GO:0006919
Name activation of cysteine-type endopeptidase activity involved in apoptotic process
Ontology Biological Process
Definition Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
PMID:14744432 PMID:18328827
Comment This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase.
GONUTS GO:0006919 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact caspase activation
narrow activation of caspase activity
narrow activation of metacaspase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR009062
InterPro IPR015142
InterPro IPR024140

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006919:
Relationship To GO:0006919 Child Term Child Term Name
Is a GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
Part of GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
Is a GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Is a GO:0097297 activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006919. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006919 based on the entire annotation set Co-occurrence statistics for GO:0006919 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-12-21 Added DEFINITION Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
2011-12-21 Updated TERM activation of cysteine-type endopeptidase activity involved in apoptotic process
2011-12-21 Added SYNONYM activation of caspase activity
2011-12-21 Added SYNONYM activation of metacaspase activity
2011-12-21 Added RELATION is a GO:0097202 (activation of cysteine-type endopeptidase activity)
2011-12-21 Deleted DEFINITION Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.
2009-03-21 Added RELATION part of GO:0006915 (apoptotic process)
2009-03-21 Deleted RELATION part of GO:0008632 (apoptotic program)
2009-02-25 Updated TERM activation of caspase activity
2009-02-22 Updated TERM activation of caspase activity
2009-01-31 Updated TERM activation of caspase activity
2009-01-31 Added SYNONYM caspase activation
2008-05-13 Added DEFINITION Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.
2008-05-12 Deleted DEFINITION Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.
2008-04-01 Updated RELATION is a GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
2008-04-01 Updated RELATION part of GO:0008632 (apoptotic program)
2003-11-04 Updated DEFINITION Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.
2002-02-06 Updated TERM caspase activation
2001-08-06 Added DEFINITION Activation of the proteolytic activity of members of the caspase family of enzymes.
2001-04-03 Updated TERM caspase activation
2001-03-30 Added TERM caspase activation

Term

Timestamp Action Category Detail
2011-12-21 Updated TERM activation of cysteine-type endopeptidase activity involved in apoptotic process
2009-02-25 Updated TERM activation of caspase activity
2009-02-22 Updated TERM activation of caspase activity
2009-01-31 Updated TERM activation of caspase activity
2002-02-06 Updated TERM caspase activation
2001-04-03 Updated TERM caspase activation
2001-03-30 Added TERM caspase activation

Definition/synonyms

Timestamp Action Category Detail
2011-12-21 Added DEFINITION Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
2011-12-21 Added SYNONYM activation of caspase activity
2011-12-21 Added SYNONYM activation of metacaspase activity
2011-12-21 Deleted DEFINITION Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.
2009-01-31 Added SYNONYM caspase activation
2008-05-13 Added DEFINITION Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.
2008-05-12 Deleted DEFINITION Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.
2003-11-04 Updated DEFINITION Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.
2001-08-06 Added DEFINITION Activation of the proteolytic activity of members of the caspase family of enzymes.

Relationships

Timestamp Action Category Detail
2011-12-21 Added RELATION is a GO:0097202 (activation of cysteine-type endopeptidase activity)
2009-03-21 Added RELATION part of GO:0006915 (apoptotic process)
2009-03-21 Deleted RELATION part of GO:0008632 (apoptotic program)
2008-04-01 Updated RELATION is a GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
2008-04-01 Updated RELATION part of GO:0008632 (apoptotic program)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
13ms