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GO:0006915 apoptosisA form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell.
Term Information
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| Type | Synonym |
| narrow | apoptotic program |
| related | signaling (initiator) caspase activity |
| exact | apoptotic cell death |
| exact | programmed cell death by apoptosis |
| exact | apoptotic programmed cell death |
| narrow | type I programmed cell death |
| Database | ID |
| INTERPRO | IPR010622 |
| INTERPRO | IPR015471 |
| INTERPRO | IPR015469 |
| INTERPRO | IPR008063 |
| INTERPRO | IPR003508 |
| INTERPRO | IPR013192 |
| INTERPRO | IPR015470 |
| INTERPRO | IPR003103 |
| INTERPRO | IPR015917 |
| INTERPRO | IPR008092 |
| INTERPRO | IPR008064 |
| Wikipedia | Apoptosis |
| INTERPRO | IPR013193 |
| INTERPRO | IPR002182 |
GO:0004200 signaling (initiator) caspase activity |
(consider GO:0006915) |
GO:0004207 effector caspase activity |
(consider GO:0006915) |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0008150 biological_process | |||||
![]() | GO:0016265 death | ||||
![]() | ![]() | GO:0009987 cellular process | |||
![]() | ![]() | ![]() | GO:0008219 cell death | ||
![]() | ![]() | ![]() | ![]() | GO:0012501 programmed cell death | |
![]() | ![]() | ![]() | ![]() | ![]() | GO:0006915 apoptosis |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0006925 inflammatory cell apoptosis |
| I | GO:0006926 virus-infected cell apoptosis |
| I | GO:0006927 transformed cell apoptosis |
| I | GO:0051402 neuron apoptosis |
| I | GO:0045476 nurse cell apoptosis |
| I | GO:0070227 lymphocyte apoptosis |
| I | GO:0043276 anoikis |
| P | GO:0070782 phosphatidylserine exposure on apoptotic cell surface |
| I | GO:0060561 apoptosis involved in morphogenesis |
| I | GO:0070059 apoptosis in response to endoplasmic reticulum stress |
| I | GO:0033028 myeloid cell apoptosis |
| I | GO:0034349 glial cell apoptosis |
| R | GO:0042981 regulation of apoptosis |
| PR | GO:0043065 positive regulation of apoptosis |
| NR | GO:0043066 negative regulation of apoptosis |
| P | GO:0006919 activation of caspase activity |
| P | GO:0006921 cell structure disassembly during apoptosis |
| P | GO:0008633 activation of pro-apoptotic gene products |
| P | GO:0008637 apoptotic mitochondrial changes |
| P | GO:0030262 apoptotic nuclear changes |
| I | GO:0001552 ovarian follicle atresia |
| I | GO:0010657 muscle cell apoptosis |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-20-04-03-08 |