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GO:0006915 apoptosis

A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell.

Term Information

ID GO:0006915
Name apoptosis
Ontology Biological Process
Definition A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell.
Comment

Synonyms

Type Synonym
narrow apoptotic program
related signaling (initiator) caspase activity
exact apoptotic cell death
exact programmed cell death by apoptosis
exact apoptotic programmed cell death
narrow type I programmed cell death

Cross-references associated with this term:

Database ID
INTERPRO IPR010622
INTERPRO IPR015471
INTERPRO IPR015469
INTERPRO IPR008063
INTERPRO IPR003508
INTERPRO IPR013192
INTERPRO IPR015470
INTERPRO IPR003103
INTERPRO IPR015917
INTERPRO IPR008092
INTERPRO IPR008064
Wikipedia Apoptosis
INTERPRO IPR013193
INTERPRO IPR002182

This term can be used instead of these obsolete terms:

GO:0004200 signaling (initiator) caspase activity (consider GO:0006915)
GO:0004207 effector caspase activity (consider GO:0006915)

Web service: term information

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Ancestor Chart

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0016265 death
GO:0009987 cellular process
GO:0008219 cell death
GO:0012501 programmed cell death
GO:0006915 apoptosis

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0006925 inflammatory cell apoptosis
I GO:0006926 virus-infected cell apoptosis
I GO:0006927 transformed cell apoptosis
I GO:0051402 neuron apoptosis
I GO:0045476 nurse cell apoptosis
I GO:0070227 lymphocyte apoptosis
I GO:0043276 anoikis
P GO:0070782 phosphatidylserine exposure on apoptotic cell surface
I GO:0060561 apoptosis involved in morphogenesis
I GO:0070059 apoptosis in response to endoplasmic reticulum stress
I GO:0033028 myeloid cell apoptosis
I GO:0034349 glial cell apoptosis
R GO:0042981 regulation of apoptosis
PR GO:0043065 positive regulation of apoptosis
NR GO:0043066 negative regulation of apoptosis
P GO:0006919 activation of caspase activity
P GO:0006921 cell structure disassembly during apoptosis
P GO:0008633 activation of pro-apoptotic gene products
P GO:0008637 apoptotic mitochondrial changes
P GO:0030262 apoptotic nuclear changes
I GO:0001552 ovarian follicle atresia
I GO:0010657 muscle cell apoptosis

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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