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GO:0006898 receptor-mediated endocytosis

Term Information

ID GO:0006898
Name receptor-mediated endocytosis
Ontology Biological Process
Definition An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
GONUTS GO:0006898 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact receptor mediated endocytosis

Cross-references

Database ID
InterPro IPR003543
InterPro IPR026296
InterPro IPR026814
InterPro IPR029513
InterPro IPR029923
InterPro IPR033329
Wikipedia Receptor-mediated_endocytosis

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006898:
Relationship To GO:0006898 Child Term Child Term Name
Is a GO:0031623 receptor internalization
Is a GO:0019065 receptor-mediated endocytosis of virus by host cell
Is a GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
Regulates GO:0048259 regulation of receptor-mediated endocytosis
Positively regulates GO:0048260 positive regulation of receptor-mediated endocytosis
Negatively regulates GO:0048261 negative regulation of receptor-mediated endocytosis
Part of GO:0098748 endocytic adaptor activity
Is a GO:0072583 clathrin-dependent endocytosis
Part of GO:0038024 cargo receptor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006898. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006898 based on the entire annotation set Co-occurrence statistics for GO:0006898 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-11-14 Added DEFINITION An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2010-11-14 Deleted DEFINITION The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2010-09-10 Added RELATION has part GO:0034381 (plasma lipoprotein particle clearance)
2009-03-02 Added XREF Wikipedia:Receptor-mediated_endocytosis
2008-05-13 Added DEFINITION The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2008-05-12 Deleted DEFINITION The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2008-04-01 Updated RELATION is a GO:0006897 (endocytosis)
2007-08-09 Added SYNONYM receptor mediated endocytosis
2007-08-09 Deleted SYNONYM receptor mediated endocytosis
2006-11-29 Deleted SYNONYM receptor-mediated endocytosis
2006-11-29 Added SYNONYM receptor mediated endocytosis
2006-11-29 Updated TERM receptor-mediated endocytosis
2005-12-15 Added SYNONYM receptor-mediated endocytosis
2002-11-27 Added DEFINITION The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2002-02-06 Updated TERM receptor mediated endocytosis
2001-04-03 Updated TERM receptor mediated endocytosis
2001-03-30 Added TERM receptor mediated endocytosis

Term

Timestamp Action Category Detail
2006-11-29 Updated TERM receptor-mediated endocytosis
2002-02-06 Updated TERM receptor mediated endocytosis
2001-04-03 Updated TERM receptor mediated endocytosis
2001-03-30 Added TERM receptor mediated endocytosis

Definition/synonyms

Timestamp Action Category Detail
2010-11-14 Added DEFINITION An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2010-11-14 Deleted DEFINITION The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2008-05-13 Added DEFINITION The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2008-05-12 Deleted DEFINITION The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
2007-08-09 Added SYNONYM receptor mediated endocytosis
2007-08-09 Deleted SYNONYM receptor mediated endocytosis
2006-11-29 Deleted SYNONYM receptor-mediated endocytosis
2006-11-29 Added SYNONYM receptor mediated endocytosis
2005-12-15 Added SYNONYM receptor-mediated endocytosis
2002-11-27 Added DEFINITION The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.

Relationships

Timestamp Action Category Detail
2010-09-10 Added RELATION has part GO:0034381 (plasma lipoprotein particle clearance)
2008-04-01 Updated RELATION is a GO:0006897 (endocytosis)

Cross-references

Timestamp Action Category Detail
2009-03-02 Added XREF Wikipedia:Receptor-mediated_endocytosis
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