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GO:0006621 protein retention in ER lumen

The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.

Term Information

ID GO:0006621
Name protein retention in ER lumen
Ontology Biological Process
Definition The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER.
Comment

Synonyms

Type Synonym
exact protein-endoplasmic reticulum retention
exact protein-ER retention
broad maintenance of protein location in ER lumen
exact retention of protein in ER
exact retention of protein in endoplasmic reticulum

Cross-references associated with this term:

Database ID
INTERPRO IPR000133

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Ancestor Table

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0051179 localization
GO:0009987 cellular process
GO:0065008 regulation of biological quality
GO:0033036 macromolecule localization
GO:0008104 protein localization
GO:0051641 cellular localization
GO:0051235 maintenance of location
GO:0051651 maintenance of location in cell
GO:0045185 maintenance of protein location
GO:0032507 maintenance of protein location in cell
GO:0006621 protein retention in ER lumen

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
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Taxonomy
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Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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