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GO:0006601 creatine biosynthetic process

Term Information

ID GO:0006601
Name creatine biosynthetic process
Ontology Biological Process
Definition The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.
GONUTS GO:0006601 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact creatine anabolism
exact creatine biosynthesis
exact creatine synthesis
exact creatine formation

Cross-Ontology Relations

Relation Other Ontology ID Term
has_output CHEBI CHEBI:16919 creatine

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006601:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006601. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006601 based on the entire annotation set Co-occurrence statistics for GO:0006601 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-03-11 Added RELATION is a GO:1901607 (alpha-amino acid biosynthetic process)
2012-11-15 Added RELATION is a GO:0042398 (cellular modified amino acid biosynthetic process)
2012-11-15 Deleted RELATION is a GO:1901566 (organonitrogen compound biosynthetic process)
2012-11-05 Added RELATION is a GO:1901566 (organonitrogen compound biosynthetic process)
2012-11-05 Deleted RELATION is a GO:0042396 (phosphagen biosynthetic process)
2010-11-25 Deleted RELATION is a GO:0009309 (amine biosynthetic process)
2010-11-05 Added RELATION is a GO:0009309 (amine biosynthetic process)
2009-07-23 Added DEFINITION The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.
2009-07-23 Deleted DEFINITION The chemical reactions and pathways resulting in the formation of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
2008-05-13 Added DEFINITION The chemical reactions and pathways resulting in the formation of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways resulting in the formation of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
2008-04-01 Updated RELATION is a GO:0006600 (creatine metabolic process)
2008-04-01 Updated RELATION is a GO:0042396 (phosphagen biosynthetic process)
2007-08-09 Added SYNONYM creatine anabolism
2007-08-09 Added SYNONYM creatine biosynthesis
2007-08-09 Added SYNONYM creatine formation
2007-08-09 Added SYNONYM creatine synthesis
2007-08-09 Deleted SYNONYM creatine biosynthesis
2007-08-09 Deleted SYNONYM creatine anabolism
2007-08-09 Deleted SYNONYM creatine formation
2007-08-09 Deleted SYNONYM creatine synthesis
2007-01-15 Updated TERM creatine biosynthetic process
2007-01-15 Added SYNONYM creatine biosynthesis
2006-05-04 Updated DEFINITION The chemical reactions and pathways resulting in the formation of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
2005-08-10 Added SYNONYM creatine formation
2005-08-10 Added SYNONYM creatine synthesis
2005-08-10 Added SYNONYM creatine anabolism
2002-11-27 Added DEFINITION The formation from simpler components of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
2002-02-06 Updated TERM creatine biosynthesis
2001-04-03 Updated TERM creatine biosynthesis
2001-03-30 Added TERM creatine biosynthesis

Term

Timestamp Action Category Detail
2007-01-15 Updated TERM creatine biosynthetic process
2002-02-06 Updated TERM creatine biosynthesis
2001-04-03 Updated TERM creatine biosynthesis
2001-03-30 Added TERM creatine biosynthesis

Definition/synonyms

Timestamp Action Category Detail
2009-07-23 Added DEFINITION The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.
2009-07-23 Deleted DEFINITION The chemical reactions and pathways resulting in the formation of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
2008-05-13 Added DEFINITION The chemical reactions and pathways resulting in the formation of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways resulting in the formation of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
2007-08-09 Added SYNONYM creatine anabolism
2007-08-09 Added SYNONYM creatine biosynthesis
2007-08-09 Added SYNONYM creatine formation
2007-08-09 Added SYNONYM creatine synthesis
2007-08-09 Deleted SYNONYM creatine biosynthesis
2007-08-09 Deleted SYNONYM creatine anabolism
2007-08-09 Deleted SYNONYM creatine formation
2007-08-09 Deleted SYNONYM creatine synthesis
2007-01-15 Added SYNONYM creatine biosynthesis
2006-05-04 Updated DEFINITION The chemical reactions and pathways resulting in the formation of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
2005-08-10 Added SYNONYM creatine formation
2005-08-10 Added SYNONYM creatine synthesis
2005-08-10 Added SYNONYM creatine anabolism
2002-11-27 Added DEFINITION The formation from simpler components of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.

Relationships

Timestamp Action Category Detail
2013-03-11 Added RELATION is a GO:1901607 (alpha-amino acid biosynthetic process)
2012-11-15 Added RELATION is a GO:0042398 (cellular modified amino acid biosynthetic process)
2012-11-15 Deleted RELATION is a GO:1901566 (organonitrogen compound biosynthetic process)
2012-11-05 Added RELATION is a GO:1901566 (organonitrogen compound biosynthetic process)
2012-11-05 Deleted RELATION is a GO:0042396 (phosphagen biosynthetic process)
2010-11-25 Deleted RELATION is a GO:0009309 (amine biosynthetic process)
2010-11-05 Added RELATION is a GO:0009309 (amine biosynthetic process)
2008-04-01 Updated RELATION is a GO:0006600 (creatine metabolic process)
2008-04-01 Updated RELATION is a GO:0042396 (phosphagen biosynthetic process)
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