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GO:0006590 thyroid hormone generation

Term Information

ID GO:0006590
Name thyroid hormone generation
Ontology Biological Process
Definition The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
Comment Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.
GONUTS GO:0006590 Wiki Page

Cross-references

Database ID
InterPro IPR029589
InterPro IPR029592
InterPro IPR029595

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006590:
Relationship To GO:0006590 Child Term Child Term Name
Regulates GO:2000609 regulation of thyroid hormone generation
Negatively regulates GO:2000610 negative regulation of thyroid hormone generation
Positively regulates GO:2000611 positive regulation of thyroid hormone generation

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006590. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006590 based on the entire annotation set Co-occurrence statistics for GO:0006590 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
2008-05-12 Deleted DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
2008-04-01 Updated RELATION is a GO:0042403 (thyroid hormone metabolic process)
2002-11-27 Added DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
2002-08-01 Updated TERM thyroid hormone generation
2002-02-06 Updated TERM thyroid hormone biosynthesis
2001-04-03 Updated TERM thyroid hormone biosynthesis
2001-03-30 Added TERM thyroid hormone biosynthesis

Term

Timestamp Action Category Detail
2002-08-01 Updated TERM thyroid hormone generation
2002-02-06 Updated TERM thyroid hormone biosynthesis
2001-04-03 Updated TERM thyroid hormone biosynthesis
2001-03-30 Added TERM thyroid hormone biosynthesis

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
2008-05-12 Deleted DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
2002-11-27 Added DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0042403 (thyroid hormone metabolic process)
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