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GO:0006540 glutamate decarboxylation to succinate

The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.

Term Information

ID GO:0006540
Name glutamate decarboxylation to succinate
Ontology Biological Process
Definition The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.
Comment

Synonyms

Type Synonym
exact 4-aminobutyrate shunt
exact gamma-aminobutyrate shunt
exact GABA shunt

Cross-references associated with this term:

Database ID
MetaCyc GLUDEG-I-PWY
MetaCyc PWY-4321

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Ancestor Table

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0009056 catabolic process
GO:0044238 primary metabolic process
GO:0044237 cellular metabolic process
GO:0009308 amine metabolic process
GO:0044106 cellular amine metabolic process
GO:0006082 organic acid metabolic process
GO:0042180 cellular ketone metabolic process
GO:0006519 cellular amino acid and derivative metabolic process
GO:0044248 cellular catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0043436 oxoacid metabolic process
GO:0019752 carboxylic acid metabolic process
GO:0016054 organic acid catabolic process
GO:0044270 cellular nitrogen compound catabolic process
GO:0043648 dicarboxylic acid metabolic process
GO:0006105 succinate metabolic process
GO:0009310 amine catabolic process
GO:0046395 carboxylic acid catabolic process
GO:0006520 cellular amino acid metabolic process
GO:0009064 glutamine family amino acid metabolic process
GO:0006536 glutamate metabolic process
GO:0009063 cellular amino acid catabolic process
GO:0009065 glutamine family amino acid catabolic process
GO:0006538 glutamate catabolic process
GO:0006540 glutamate decarboxylation to succinate

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

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Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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13ms
Stand-alone
Hostnametomcat-7.ebi.ac.uk
Uptime16:38 12/10/2009
Data version2009-11-24-04-03-40
Terminal
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