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GO:0006508 proteolysis

Term Information

ID GO:0006508
Name proteolysis
Ontology Biological Process
Definition The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
Comment This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein maturation.
GONUTS GO:0006508 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact peptidolysis
narrow ATP-dependent proteolysis

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_pir462

Cross-references

Database ID
InterPro IPR000013
InterPro IPR000036
InterPro IPR000081
InterPro IPR000126
InterPro IPR000177
InterPro IPR000180
InterPro IPR000199
InterPro IPR000200
InterPro IPR000209
InterPro IPR000223
InterPro IPR000250
InterPro IPR000317
InterPro IPR000395
InterPro IPR000588
InterPro IPR000642
InterPro IPR000667
InterPro IPR000668
InterPro IPR000696
InterPro IPR000710
InterPro IPR000718
InterPro IPR000755
InterPro IPR000787
InterPro IPR000816
InterPro IPR000819
InterPro IPR000834
InterPro IPR000841
InterPro IPR000855
InterPro IPR000930
InterPro IPR001096
InterPro IPR001160
InterPro IPR001193
InterPro IPR001254
InterPro IPR001261
InterPro IPR001300
InterPro IPR001309
InterPro IPR001314
InterPro IPR001316
InterPro IPR001333
InterPro IPR001375
InterPro IPR001384
InterPro IPR001431
InterPro IPR001456
InterPro IPR001461
InterPro IPR001506
InterPro IPR001539
InterPro IPR001548
InterPro IPR001563
InterPro IPR001567
InterPro IPR001577
InterPro IPR001590
InterPro IPR001641
InterPro IPR001665
InterPro IPR001714
InterPro IPR001730
InterPro IPR001767
InterPro IPR001769
InterPro IPR001815
InterPro IPR001818
InterPro IPR001847
InterPro IPR001872
InterPro IPR001907
InterPro IPR001915
InterPro IPR001930
InterPro IPR001940
InterPro IPR001948
InterPro IPR001967
InterPro IPR001969
InterPro IPR001984
InterPro IPR001995
InterPro IPR002138
InterPro IPR002142
InterPro IPR002169
InterPro IPR002398
InterPro IPR002410
InterPro IPR002467
InterPro IPR002468
InterPro IPR002469
InterPro IPR002470
InterPro IPR002471
InterPro IPR002540
InterPro IPR002610
InterPro IPR002704
InterPro IPR002705
InterPro IPR002870
InterPro IPR002884
InterPro IPR003111
InterPro IPR003146
InterPro IPR003653
InterPro IPR003709
InterPro IPR003966
InterPro IPR004106
InterPro IPR004109
InterPro IPR004134
InterPro IPR004236
InterPro IPR004387
InterPro IPR004438
InterPro IPR004447
InterPro IPR004635
InterPro IPR004815
InterPro IPR005073
InterPro IPR005074
InterPro IPR005080
InterPro IPR005081
InterPro IPR005151
InterPro IPR005314
InterPro IPR005317
InterPro IPR005320
InterPro IPR005322
InterPro IPR005536
InterPro IPR005944
InterPro IPR005945
InterPro IPR006026
InterPro IPR006199
InterPro IPR006200
InterPro IPR006586
InterPro IPR006746
InterPro IPR008252
InterPro IPR008256
InterPro IPR008257
InterPro IPR008268
InterPro IPR008269
InterPro IPR008283
InterPro IPR008294
InterPro IPR008330
InterPro IPR008353
InterPro IPR008357
InterPro IPR008750
InterPro IPR008753
InterPro IPR008757
InterPro IPR008758
InterPro IPR008915
InterPro IPR009119
InterPro IPR009120
InterPro IPR011163
InterPro IPR011600
InterPro IPR011782
InterPro IPR011783
InterPro IPR011844
InterPro IPR012091
InterPro IPR012778
InterPro IPR012848
InterPro IPR012907
InterPro IPR013016
InterPro IPR013578
InterPro IPR014394
InterPro IPR015251
InterPro IPR015470
InterPro IPR015471
InterPro IPR015567
InterPro IPR015570
InterPro IPR015956
InterPro IPR016129
InterPro IPR016293
InterPro IPR016294
InterPro IPR017051
InterPro IPR018044
InterPro IPR018114
InterPro IPR018202
InterPro IPR018215
InterPro IPR018497
InterPro IPR018992
InterPro IPR019103
InterPro IPR020079
InterPro IPR021158
InterPro IPR021190
InterPro IPR022281
InterPro IPR022684
InterPro IPR023612
InterPro IPR023645
InterPro IPR023662
InterPro IPR026280
InterPro IPR026918
InterPro IPR027063
InterPro IPR027543
InterPro IPR028388
InterPro IPR028536
InterPro IPR028595
InterPro IPR028687
InterPro IPR028688
InterPro IPR028693
InterPro IPR028697
InterPro IPR028700
InterPro IPR028705
InterPro IPR028707
InterPro IPR028708
InterPro IPR028709
InterPro IPR028711
InterPro IPR028716
InterPro IPR028718
InterPro IPR028723
InterPro IPR028724
InterPro IPR028726
InterPro IPR028729
InterPro IPR028733
InterPro IPR028735
InterPro IPR028736
InterPro IPR029531
InterPro IPR029539
InterPro IPR029642
InterPro IPR029643
InterPro IPR029727
InterPro IPR029761
InterPro IPR029762
InterPro IPR030397
InterPro IPR030400
InterPro IPR030433
UniProtKB-KW Protease
Wikipedia Proteolysis

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0006510 ATP-dependent proteolysis CONSIDER GO:0006508

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006508:
Relationship To GO:0006508 Child Term Child Term Name
Is a GO:0051603 proteolysis involved in cellular protein catabolic process
Regulates GO:0030162 regulation of proteolysis
Negatively regulates GO:0045861 negative regulation of proteolysis
Positively regulates GO:0045862 positive regulation of proteolysis
Is a GO:0033619 membrane protein proteolysis
Is a GO:0097264 self proteolysis
Is a GO:0035897 proteolysis in other organism
Part of GO:0008233 peptidase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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ID Mapping

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006508. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006508 based on the entire annotation set Co-occurrence statistics for GO:0006508 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-05-04 Added RELATION is a GO:0019538 (protein metabolic process)
2014-05-04 Deleted RELATION is a GO:0016485 (protein processing)
2014-03-07 Added RELATION is a GO:0016485 (protein processing)
2014-03-07 Deleted RELATION is a GO:0019538 (protein metabolic process)
2013-04-18 Updated SLIM goslim_pir
2010-11-10 Deleted DEFINITION The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds.
2010-11-10 Added DEFINITION The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2010-01-31 Added RELATION is a GO:0019538 (protein metabolic process)
2010-01-31 Deleted RELATION is a GO:0030163 (protein catabolic process)
2009-05-21 Added RELATION is a GO:0030163 (protein catabolic process)
2009-05-21 Deleted RELATION is a GO:0044267 (cellular protein metabolic process)
2009-03-21 Added SYNONYM ATP-dependent proteolysis
2009-03-15 Added DEFINITION The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds.
2009-03-15 Deleted DEFINITION The hydrolysis of a peptide bond or bonds within a protein.
2009-03-02 Added XREF Wikipedia:Proteolysis
2008-06-09 Added SLIM goslim_pir
2008-05-13 Added DEFINITION The hydrolysis of a peptide bond or bonds within a protein.
2008-05-12 Deleted DEFINITION The hydrolysis of a peptide bond or bonds within a protein.
2008-04-01 Updated RELATION is a GO:0044267 (cellular protein metabolic process)
2007-08-09 Added SYNONYM peptidolysis
2007-08-09 Deleted SYNONYM peptidolysis
2005-09-19 Updated TERM proteolysis
2005-09-19 Added SYNONYM peptidolysis
2005-09-17 Updated DEFINITION The hydrolysis of a peptide bond or bonds within a protein.
2003-03-19 Deleted SYNONYM protein dergadation
2002-11-27 Added DEFINITION Destruction of a protein or peptide by hydrolysis of peptide bonds.
2002-02-06 Updated TERM proteolysis and peptidolysis
2001-08-24 Added SYNONYM protein dergadation
2001-04-03 Updated TERM proteolysis and peptidolysis
2001-03-30 Added TERM proteolysis and peptidolysis

Term

Timestamp Action Category Detail
2005-09-19 Updated TERM proteolysis
2002-02-06 Updated TERM proteolysis and peptidolysis
2001-04-03 Updated TERM proteolysis and peptidolysis
2001-03-30 Added TERM proteolysis and peptidolysis

Definition/synonyms

Timestamp Action Category Detail
2010-11-10 Deleted DEFINITION The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds.
2010-11-10 Added DEFINITION The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2009-03-21 Added SYNONYM ATP-dependent proteolysis
2009-03-15 Added DEFINITION The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds.
2009-03-15 Deleted DEFINITION The hydrolysis of a peptide bond or bonds within a protein.
2008-05-13 Added DEFINITION The hydrolysis of a peptide bond or bonds within a protein.
2008-05-12 Deleted DEFINITION The hydrolysis of a peptide bond or bonds within a protein.
2007-08-09 Added SYNONYM peptidolysis
2007-08-09 Deleted SYNONYM peptidolysis
2005-09-19 Added SYNONYM peptidolysis
2005-09-17 Updated DEFINITION The hydrolysis of a peptide bond or bonds within a protein.
2003-03-19 Deleted SYNONYM protein dergadation
2002-11-27 Added DEFINITION Destruction of a protein or peptide by hydrolysis of peptide bonds.
2001-08-24 Added SYNONYM protein dergadation

Relationships

Timestamp Action Category Detail
2014-05-04 Added RELATION is a GO:0019538 (protein metabolic process)
2014-05-04 Deleted RELATION is a GO:0016485 (protein processing)
2014-03-07 Added RELATION is a GO:0016485 (protein processing)
2014-03-07 Deleted RELATION is a GO:0019538 (protein metabolic process)
2010-01-31 Added RELATION is a GO:0019538 (protein metabolic process)
2010-01-31 Deleted RELATION is a GO:0030163 (protein catabolic process)
2009-05-21 Added RELATION is a GO:0030163 (protein catabolic process)
2009-05-21 Deleted RELATION is a GO:0044267 (cellular protein metabolic process)
2008-04-01 Updated RELATION is a GO:0044267 (cellular protein metabolic process)

Cross-references

Timestamp Action Category Detail
2009-03-02 Added XREF Wikipedia:Proteolysis

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_pir
2008-06-09 Added SLIM goslim_pir
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