spacer

GO:0006469 negative regulation of protein kinase activity

Term Information

ID GO:0006469
Name negative regulation of protein kinase activity
Ontology Biological Process
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
GONUTS GO:0006469 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow inhibition of protein kinase activity
exact down regulation of protein kinase activity
exact down-regulation of protein kinase activity
exact downregulation of protein kinase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR004171

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006469:
Relationship To GO:0006469 Child Term Child Term Name
Is a GO:0051389 inactivation of MAPKK activity
Is a GO:0071901 negative regulation of protein serine/threonine kinase activity
Is a GO:0061099 negative regulation of protein tyrosine kinase activity
Is a GO:0032112 negative regulation of protein histidine kinase activity
Is a GO:1902948 negative regulation of tau-protein kinase activity
Is a GO:0039584 suppression by virus of host protein kinase activity
Part of GO:0004860 protein kinase inhibitor activity
Part of GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
Is a GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006469. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006469 based on the entire annotation set Co-occurrence statistics for GO:0006469 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-06-12 Added RELATION is a GO:0001933 (negative regulation of protein phosphorylation)
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
2010-06-15 Added RELATION negatively regulates GO:0004672 (protein kinase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004672 (protein kinase activity)
2010-06-09 Updated TERM negative regulation of protein kinase activity
2010-06-08 Updated TERM negative regulation of protein kinase activity
2010-06-08 Added RELATION negatively regulates GO:0004672 (protein kinase activity)
2009-02-25 Updated TERM negative regulation of protein kinase activity
2009-02-25 Deleted RELATION negatively regulates GO:0004672 (protein kinase activity)
2009-02-22 Added RELATION negatively regulates GO:0004672 (protein kinase activity)
2009-02-22 Updated TERM negative regulation of protein kinase activity
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity.
2008-04-01 Updated RELATION is a GO:0045859 (regulation of protein kinase activity)
2008-04-01 Updated RELATION is a GO:0033673 (negative regulation of kinase activity)
2007-08-09 Added SYNONYM inhibition of protein kinase activity
2007-08-09 Added SYNONYM down regulation of protein kinase activity
2007-08-09 Added SYNONYM down-regulation of protein kinase activity
2007-08-09 Added SYNONYM downregulation of protein kinase activity
2007-08-09 Deleted SYNONYM down regulation of protein kinase activity
2007-08-09 Deleted SYNONYM down-regulation of protein kinase activity
2007-08-09 Deleted SYNONYM downregulation of protein kinase activity
2007-08-09 Deleted SYNONYM inhibition of protein kinase activity
2007-02-23 Added SYNONYM down regulation of protein kinase activity
2007-02-23 Added SYNONYM down-regulation of protein kinase activity
2007-02-23 Added SYNONYM downregulation of protein kinase activity
2007-02-23 Added SYNONYM inhibition of protein kinase activity
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of protein kinase activity.
2002-11-27 Added DEFINITION Any process that stops, prevents or reduces the rate of protein kinase activity.
2002-08-20 Updated TERM negative regulation of protein kinase activity
2002-07-15 Updated TERM negative regulation of protein kinase
2002-02-06 Updated TERM protein kinase inhibition
2001-04-03 Updated TERM protein kinase inhibition
2001-03-30 Added TERM protein kinase inhibition

Term

Timestamp Action Category Detail
2010-06-09 Updated TERM negative regulation of protein kinase activity
2010-06-08 Updated TERM negative regulation of protein kinase activity
2009-02-25 Updated TERM negative regulation of protein kinase activity
2009-02-22 Updated TERM negative regulation of protein kinase activity
2002-08-20 Updated TERM negative regulation of protein kinase activity
2002-07-15 Updated TERM negative regulation of protein kinase
2002-02-06 Updated TERM protein kinase inhibition
2001-04-03 Updated TERM protein kinase inhibition
2001-03-30 Added TERM protein kinase inhibition

Definition/synonyms

Timestamp Action Category Detail
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity.
2007-08-09 Added SYNONYM inhibition of protein kinase activity
2007-08-09 Added SYNONYM down regulation of protein kinase activity
2007-08-09 Added SYNONYM down-regulation of protein kinase activity
2007-08-09 Added SYNONYM downregulation of protein kinase activity
2007-08-09 Deleted SYNONYM down regulation of protein kinase activity
2007-08-09 Deleted SYNONYM down-regulation of protein kinase activity
2007-08-09 Deleted SYNONYM downregulation of protein kinase activity
2007-08-09 Deleted SYNONYM inhibition of protein kinase activity
2007-02-23 Added SYNONYM down regulation of protein kinase activity
2007-02-23 Added SYNONYM down-regulation of protein kinase activity
2007-02-23 Added SYNONYM downregulation of protein kinase activity
2007-02-23 Added SYNONYM inhibition of protein kinase activity
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of protein kinase activity.
2002-11-27 Added DEFINITION Any process that stops, prevents or reduces the rate of protein kinase activity.

Relationships

Timestamp Action Category Detail
2012-06-12 Added RELATION is a GO:0001933 (negative regulation of protein phosphorylation)
2010-06-15 Added RELATION negatively regulates GO:0004672 (protein kinase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004672 (protein kinase activity)
2010-06-08 Added RELATION negatively regulates GO:0004672 (protein kinase activity)
2009-02-25 Deleted RELATION negatively regulates GO:0004672 (protein kinase activity)
2009-02-22 Added RELATION negatively regulates GO:0004672 (protein kinase activity)
2008-04-01 Updated RELATION is a GO:0045859 (regulation of protein kinase activity)
2008-04-01 Updated RELATION is a GO:0033673 (negative regulation of kinase activity)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
23ms