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GO:0003756 protein disulfide isomerase activity

Term Information

ID GO:0003756
Name protein disulfide isomerase activity
Ontology Molecular Function
Definition Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
Secondary IDs GO:0006467
GONUTS GO:0003756 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact protein thiol-disulfide exchange
exact disulphide bond formation
related protein cysteine-thiol oxidation
exact protein disulphide isomerase activity
broad protein disulfide-isomerase
exact protein disulfide-isomerase reaction
related S-S rearrangase activity
exact disulphide bond biosynthesis
exact protein thiol-disulphide exchange

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 5.3.4.1
InterPro IPR007266
InterPro IPR017068
InterPro IPR017758
MetaCyc 5.3.4.1-RXN

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0000008 thioredoxin CONSIDER GO:0003756
GO:0006484 protein cysteine-thiol oxidation CONSIDER GO:0003756
GO:0009487 glutaredoxin CONSIDER GO:0003756
GO:0030508 thiol-disulfide exchange intermediate activity CONSIDER GO:0003756
GO:0006466 protein disulfide-isomerase reaction REPLACEDBY GO:0003756

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003756:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003756. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003756 based on the entire annotation set Co-occurrence statistics for GO:0003756 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-09-26 Deleted RELATION is a GO:0016862 (intramolecular oxidoreductase activity, interconverting keto- and enol-groups)
2012-12-06 Added SYNONYM disulphide bond formation
2012-12-06 Added RELATION part of GO:0006457 (protein folding)
2012-12-06 Added SECONDARY GO:0006467 (protein thiol-disulfide exchange)
2012-12-06 Added SYNONYM disulphide bond biosynthesis
2012-12-06 Added SYNONYM protein thiol-disulphide exchange
2012-12-06 Added SYNONYM protein thiol-disulfide exchange
2009-05-21 Deleted XREF MetaCyc:DISULISOM-RXN
2008-05-13 Added DEFINITION Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
2008-05-12 Deleted DEFINITION Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
2008-04-01 Updated RELATION is a GO:0016864 (intramolecular oxidoreductase activity, transposing S-S bonds)
2008-04-01 Updated RELATION is a GO:0016862 (intramolecular oxidoreductase activity, interconverting keto- and enol-groups)
2007-11-08 Added SYNONYM protein disulfide-isomerase
2007-09-06 Added SYNONYM S-S rearrangase activity
2007-09-06 Added SYNONYM protein disulfide-isomerase reaction
2007-09-06 Deleted SYNONYM protein disulfide-isomerase reaction
2007-08-09 Added SYNONYM protein cysteine-thiol oxidation
2007-08-09 Added SYNONYM protein disulfide-isomerase reaction
2007-08-09 Added SYNONYM protein disulphide isomerase activity
2007-08-09 Deleted SYNONYM protein cysteine-thiol oxidation
2007-08-09 Deleted SYNONYM protein disulfide-isomerase reaction
2007-08-09 Deleted SYNONYM protein disulphide isomerase activity
2005-08-10 Added SYNONYM protein cysteine-thiol oxidation
2005-08-10 Added SYNONYM protein disulfide-isomerase reaction
2004-04-19 Added SYNONYM protein disulphide isomerase activity
2004-04-16 Deleted SYNONYM protein disulphide isomerase activity
2004-01-07 Updated DEFINITION Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
2003-11-13 Added SYNONYM protein disulphide isomerase activity
2003-10-27 Added XREF MetaCyc:DISULISOM-RXN
2003-10-27 Added XREF MetaCyc:5.3.4.1-RXN
2003-08-06 Updated DEFINITION Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures.
2003-03-19 Updated TERM protein disulfide isomerase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures.
2002-02-06 Updated TERM protein disulfide isomerase
2001-04-03 Updated TERM protein disulfide isomerase
2001-03-30 Added XREF EC:5.3.4.1
2001-03-30 Added TERM protein disulfide isomerase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM protein disulfide isomerase activity
2002-02-06 Updated TERM protein disulfide isomerase
2001-04-03 Updated TERM protein disulfide isomerase
2001-03-30 Added TERM protein disulfide isomerase

Definition/synonyms

Timestamp Action Category Detail
2012-12-06 Added SYNONYM disulphide bond formation
2012-12-06 Added SYNONYM disulphide bond biosynthesis
2012-12-06 Added SYNONYM protein thiol-disulphide exchange
2012-12-06 Added SYNONYM protein thiol-disulfide exchange
2008-05-13 Added DEFINITION Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
2008-05-12 Deleted DEFINITION Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
2007-11-08 Added SYNONYM protein disulfide-isomerase
2007-09-06 Added SYNONYM S-S rearrangase activity
2007-09-06 Added SYNONYM protein disulfide-isomerase reaction
2007-09-06 Deleted SYNONYM protein disulfide-isomerase reaction
2007-08-09 Added SYNONYM protein cysteine-thiol oxidation
2007-08-09 Added SYNONYM protein disulfide-isomerase reaction
2007-08-09 Added SYNONYM protein disulphide isomerase activity
2007-08-09 Deleted SYNONYM protein cysteine-thiol oxidation
2007-08-09 Deleted SYNONYM protein disulfide-isomerase reaction
2007-08-09 Deleted SYNONYM protein disulphide isomerase activity
2005-08-10 Added SYNONYM protein cysteine-thiol oxidation
2005-08-10 Added SYNONYM protein disulfide-isomerase reaction
2004-04-19 Added SYNONYM protein disulphide isomerase activity
2004-04-16 Deleted SYNONYM protein disulphide isomerase activity
2004-01-07 Updated DEFINITION Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
2003-11-13 Added SYNONYM protein disulphide isomerase activity
2003-08-06 Updated DEFINITION Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures.
2002-11-27 Added DEFINITION Catalysis of the reaction: rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures.

Relationships

Timestamp Action Category Detail
2013-09-26 Deleted RELATION is a GO:0016862 (intramolecular oxidoreductase activity, interconverting keto- and enol-groups)
2012-12-06 Added RELATION part of GO:0006457 (protein folding)
2008-04-01 Updated RELATION is a GO:0016864 (intramolecular oxidoreductase activity, transposing S-S bonds)
2008-04-01 Updated RELATION is a GO:0016862 (intramolecular oxidoreductase activity, interconverting keto- and enol-groups)

Cross-references

Timestamp Action Category Detail
2009-05-21 Deleted XREF MetaCyc:DISULISOM-RXN
2003-10-27 Added XREF MetaCyc:DISULISOM-RXN
2003-10-27 Added XREF MetaCyc:5.3.4.1-RXN
2001-03-30 Added XREF EC:5.3.4.1

Other

Timestamp Action Category Detail
2012-12-06 Added SECONDARY GO:0006467 (protein thiol-disulfide exchange)
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