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GO:0006457 protein folding

Term Information

ID GO:0006457
Name protein folding
Ontology Biological Process
Definition The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
Secondary IDs GO:0007022 GO:0007024 GO:0007025
GONUTS GO:0006457 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow chaperonin-mediated tubulin folding
related chaperone activity
narrow beta-tubulin folding
narrow alpha-tubulin folding
related chaperonin ATPase activity
related co-chaperone activity
related co-chaperonin activity
related glycoprotein-specific chaperone activity
related non-chaperonin molecular chaperone ATPase activity
related protein complex assembly, multichaperone pathway

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_candida89
goslim_pir462
goslim_yeast169
goslim_generic149
goslim_pombe48
goslim_aspergillus85

Cross-references

Database ID
InterPro IPR000397
InterPro IPR000740
InterPro IPR000774
InterPro IPR001179
InterPro IPR001404
InterPro IPR001580
InterPro IPR002130
InterPro IPR002194
InterPro IPR002777
InterPro IPR004487
InterPro IPR004640
InterPro IPR004961
InterPro IPR008880
InterPro IPR008881
InterPro IPR008971
InterPro IPR009012
InterPro IPR009169
InterPro IPR010236
InterPro IPR011599
InterPro IPR012406
InterPro IPR012713
InterPro IPR012714
InterPro IPR012715
InterPro IPR012716
InterPro IPR012717
InterPro IPR012718
InterPro IPR012719
InterPro IPR012720
InterPro IPR012721
InterPro IPR012722
InterPro IPR012724
InterPro IPR012725
InterPro IPR015317
InterPro IPR016153
InterPro IPR016154
InterPro IPR016304
InterPro IPR016655
InterPro IPR016661
InterPro IPR018369
InterPro IPR018370
InterPro IPR019805
InterPro IPR020818
InterPro IPR020892
InterPro IPR023034
InterPro IPR024237
InterPro IPR024936
InterPro IPR027235
InterPro IPR028790
UniProtKB-KW Rotamase
Wikipedia Protein_folding

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0003754 chaperone activity CONSIDER GO:0006457
GO:0003759 glycoprotein-specific chaperone activity CONSIDER GO:0006457
GO:0003763 chaperonin ATPase activity CONSIDER GO:0006457
GO:0003767 co-chaperone activity CONSIDER GO:0006457
GO:0003772 co-chaperonin activity CONSIDER GO:0006457
GO:0006462 protein complex assembly, multichaperone pathway CONSIDER GO:0006457
GO:0008571 non-chaperonin molecular chaperone ATPase activity CONSIDER GO:0006457
GO:0010538 Hsp27 protein regulator activity CONSIDER GO:0006457
GO:0010539 Hsp27 protein inhibitor activity CONSIDER GO:0006457
GO:0010545 Hsp90 protein regulator activity CONSIDER GO:0006457
GO:0010546 Hsp90 protein inhibitor activity CONSIDER GO:0006457
GO:0017078 Hsc70 protein regulator activity CONSIDER GO:0006457
GO:0030188 chaperone regulator activity CONSIDER GO:0006457
GO:0030189 chaperone activator activity CONSIDER GO:0006457
GO:0030190 chaperone inhibitor activity CONSIDER GO:0006457
GO:0030191 Hsp70/Hsc70 protein inhibitor activity CONSIDER GO:0006457
GO:0030192 Hsp70/Hsc70 protein regulator activity CONSIDER GO:0006457

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006457:
Relationship To GO:0006457 Child Term Child Term Name
Is a GO:0006458 'de novo' protein folding
Is a GO:0042026 protein refolding
Part of GO:0044183 protein binding involved in protein folding
Is a GO:0022417 protein maturation by protein folding
Is a GO:0034975 protein folding in endoplasmic reticulum
Part of GO:0003756 protein disulfide isomerase activity
Is a GO:0007023 post-chaperonin tubulin folding pathway
Is a GO:0061077 chaperone-mediated protein folding
Regulates GO:1903332 regulation of protein folding
Negatively regulates GO:1903333 negative regulation of protein folding
Positively regulates GO:1903334 positive regulation of protein folding

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006457. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006457 based on the entire annotation set Co-occurrence statistics for GO:0006457 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_pombe
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2011-11-05 Added SLIM goslim_aspergillus
2010-12-05 Added SLIM goslim_generic
2009-05-11 Added SLIM goslim_pombe
2009-04-29 Added SECONDARY GO:0007025 (beta-tubulin folding)
2009-04-29 Added SECONDARY GO:0007024 (alpha-tubulin folding)
2009-04-29 Added SECONDARY GO:0007022 (chaperonin-mediated tubulin folding)
2009-04-29 Added SYNONYM alpha-tubulin folding
2009-04-29 Added SYNONYM beta-tubulin folding
2009-04-29 Added SYNONYM chaperonin-mediated tubulin folding
2009-03-02 Added XREF Wikipedia:Protein_folding
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_candida
2008-05-13 Added DEFINITION The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2008-05-12 Deleted DEFINITION The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2008-04-01 Updated RELATION is a GO:0044267 (cellular protein metabolic process)
2007-08-09 Added SYNONYM chaperone activity
2007-08-09 Added SYNONYM chaperonin ATPase activity
2007-08-09 Added SYNONYM co-chaperone activity
2007-08-09 Added SYNONYM co-chaperonin activity
2007-08-09 Added SYNONYM glycoprotein-specific chaperone activity
2007-08-09 Added SYNONYM non-chaperonin molecular chaperone ATPase activity
2007-08-09 Added SYNONYM protein complex assembly, multichaperone pathway
2007-08-09 Deleted SYNONYM chaperone activity
2007-08-09 Deleted SYNONYM chaperonin ATPase activity
2007-08-09 Deleted SYNONYM co-chaperone activity
2007-08-09 Deleted SYNONYM co-chaperonin activity
2007-08-09 Deleted SYNONYM glycoprotein-specific chaperone activity
2007-08-09 Deleted SYNONYM non-chaperonin molecular chaperone ATPase activity
2007-08-09 Deleted SYNONYM protein complex assembly, multichaperone pathway
2005-08-10 Added SYNONYM chaperonin ATPase activity
2005-08-10 Added SYNONYM co-chaperone activity
2005-08-10 Added SYNONYM co-chaperonin activity
2005-08-10 Added SYNONYM glycoprotein-specific chaperone activity
2005-08-10 Added SYNONYM non-chaperonin molecular chaperone ATPase activity
2005-08-10 Added SYNONYM protein complex assembly, multichaperone pathway
2005-04-27 Updated DEFINITION The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2004-07-26 Added SYNONYM chaperone activity
2004-07-22 Updated DEFINITION The process of assisting in the noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2004-07-16 Added DEFINITION Processes that assist in the noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2002-02-06 Updated TERM protein folding
2001-04-03 Updated TERM protein folding
2001-03-30 Added TERM protein folding

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM protein folding
2001-04-03 Updated TERM protein folding
2001-03-30 Added TERM protein folding

Definition/synonyms

Timestamp Action Category Detail
2009-04-29 Added SYNONYM alpha-tubulin folding
2009-04-29 Added SYNONYM beta-tubulin folding
2009-04-29 Added SYNONYM chaperonin-mediated tubulin folding
2008-05-13 Added DEFINITION The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2008-05-12 Deleted DEFINITION The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2007-08-09 Added SYNONYM chaperone activity
2007-08-09 Added SYNONYM chaperonin ATPase activity
2007-08-09 Added SYNONYM co-chaperone activity
2007-08-09 Added SYNONYM co-chaperonin activity
2007-08-09 Added SYNONYM glycoprotein-specific chaperone activity
2007-08-09 Added SYNONYM non-chaperonin molecular chaperone ATPase activity
2007-08-09 Added SYNONYM protein complex assembly, multichaperone pathway
2007-08-09 Deleted SYNONYM chaperone activity
2007-08-09 Deleted SYNONYM chaperonin ATPase activity
2007-08-09 Deleted SYNONYM co-chaperone activity
2007-08-09 Deleted SYNONYM co-chaperonin activity
2007-08-09 Deleted SYNONYM glycoprotein-specific chaperone activity
2007-08-09 Deleted SYNONYM non-chaperonin molecular chaperone ATPase activity
2007-08-09 Deleted SYNONYM protein complex assembly, multichaperone pathway
2005-08-10 Added SYNONYM chaperonin ATPase activity
2005-08-10 Added SYNONYM co-chaperone activity
2005-08-10 Added SYNONYM co-chaperonin activity
2005-08-10 Added SYNONYM glycoprotein-specific chaperone activity
2005-08-10 Added SYNONYM non-chaperonin molecular chaperone ATPase activity
2005-08-10 Added SYNONYM protein complex assembly, multichaperone pathway
2005-04-27 Updated DEFINITION The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2004-07-26 Added SYNONYM chaperone activity
2004-07-22 Updated DEFINITION The process of assisting in the noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2004-07-16 Added DEFINITION Processes that assist in the noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0044267 (cellular protein metabolic process)

Cross-references

Timestamp Action Category Detail
2009-03-02 Added XREF Wikipedia:Protein_folding

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_pombe
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2011-11-05 Added SLIM goslim_aspergillus
2010-12-05 Added SLIM goslim_generic
2009-05-11 Added SLIM goslim_pombe
2009-04-29 Added SECONDARY GO:0007025 (beta-tubulin folding)
2009-04-29 Added SECONDARY GO:0007024 (alpha-tubulin folding)
2009-04-29 Added SECONDARY GO:0007022 (chaperonin-mediated tubulin folding)
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_candida
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