GO:0006342 chromatin silencing

Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.

Term Information

ID	GO:0006342
Name	chromatin silencing
Ontology	Biological Process
Definition	Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
Comment	Note that this process is the opposite of chromatin-mediated maintenance of transcription. This regulation is exemplified by members of the Polycomb group, which maintain the inactive state of homeotic gene transcription.

Synonyms

Type	Synonym
exact	TGS
exact	chromatin-mediated maintenance of transcriptional inactivation
exact	chromatin-mediated silencing
related	heterochromatic silencing
exact	transcriptional gene silencing

Cross-references associated with this term:

Database	ID
INTERPRO	IPR003000
INTERPRO	IPR007654

This term can be used instead of these obsolete terms:

GO:0006340 negative regulation of transcription of homeotic gene (Polycomb group)	(consider GO:0006342)
GO:0006339 positive regulation of transcription of homeotic gene (trithorax group)	(consider GO:0006342)
GO:0045891 negative regulation of transcription of homeotic gene (trithorax group)	(consider GO:0006342)
GO:0045890 regulation of transcription of homeotic gene (trithorax group)	(consider GO:0006342)
GO:0045889 positive regulation of transcription of homeotic gene (Polycomb group)	(consider GO:0006342)
GO:0045888 regulation of transcription of homeotic gene (Polycomb group)	(consider GO:0006342)

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Ancestor Table

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GO:0008150 biological_process

GO:0009987 cellular process

GO:0065007 biological regulation

GO:0008152 metabolic process

GO:0006807 nitrogen compound metabolic process

GO:0043170 macromolecule metabolic process

GO:0044238 primary metabolic process

GO:0009058 biosynthetic process

GO:0050789 regulation of biological process

GO:0043283 biopolymer metabolic process

GO:0048519 negative regulation of biological process

GO:0010467 gene expression

GO:0044237 cellular metabolic process

GO:0050794 regulation of cellular process

GO:0019222 regulation of metabolic process

GO:0009059 macromolecule biosynthetic process

GO:0044249 cellular biosynthetic process

GO:0044260 cellular macromolecule metabolic process

GO:0051171 regulation of nitrogen compound metabolic process

GO:0009889 regulation of biosynthetic process

GO:0060255 regulation of macromolecule metabolic process

GO:0048523 negative regulation of cellular process

GO:0080090 regulation of primary metabolic process

GO:0043284 biopolymer biosynthetic process

GO:0009892 negative regulation of metabolic process

GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

GO:0034960 cellular biopolymer metabolic process

GO:0010468 regulation of gene expression

GO:0031323 regulation of cellular metabolic process

GO:0034645 cellular macromolecule biosynthetic process

GO:0009890 negative regulation of biosynthetic process

GO:0051172 negative regulation of nitrogen compound metabolic process

GO:0010605 negative regulation of macromolecule metabolic process

GO:0040029 regulation of gene expression, epigenetic

GO:0010556 regulation of macromolecule biosynthetic process

GO:0016070 RNA metabolic process

GO:0031326 regulation of cellular biosynthetic process

GO:0010629 negative regulation of gene expression

GO:0031324 negative regulation of cellular metabolic process

GO:0034961 cellular biopolymer biosynthetic process

GO:0032774 RNA biosynthetic process

GO:0016458 gene silencing

GO:0045814 negative regulation of gene expression, epigenetic

GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

GO:0010558 negative regulation of macromolecule biosynthetic process

GO:0031327 negative regulation of cellular biosynthetic process

GO:0006350 transcription

GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

GO:0006351 transcription, DNA-dependent

GO:0051252 regulation of RNA metabolic process

GO:0051253 negative regulation of RNA metabolic process

GO:0045449 regulation of transcription

GO:0006355 regulation of transcription, DNA-dependent

GO:0016481 negative regulation of transcription

GO:0045892 negative regulation of transcription, DNA-dependent

GO:0006342 chromatin silencing

Relationship key

Code	Relationship
	part of
	is a
	regulates
	+ve regulates
	-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:

I	GO:0000183 chromatin silencing at rDNA
P	GO:0006343 establishment of chromatin silencing
P	GO:0006344 maintenance of chromatin silencing
I	GO:0006348 chromatin silencing at telomere
I	GO:0030702 chromatin silencing at centromere
R	GO:0031935 regulation of chromatin silencing
NR	GO:0031936 negative regulation of chromatin silencing
PR	GO:0031937 positive regulation of chromatin silencing
I	GO:0006346 methylation-dependent chromatin silencing
I	GO:0030466 chromatin silencing at silent mating-type cassette
I	GO:0031048 chromatin silencing by small RNA
P	GO:0070868 heterochromatin organization involved in chromatin silencing

Relationship key

Code	Relationship
P	part of
I	is a

Protein Annotation

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Co-occurring Terms

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22ms

GO:0006342 chromatin silencing

Term Information

Synonyms

Cross-references associated with this term:

This term can be used instead of these obsolete terms:

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Ancestor Table

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Child Terms

Relationship key

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Co-occurring Terms

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