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GO:0006309 apoptotic DNA fragmentation

Term Information

ID GO:0006309
Name apoptotic DNA fragmentation
Ontology Biological Process
Definition The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
PMID:15723341 PMID:23379520
Comment DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
Secondary IDs GO:0008178
GONUTS GO:0006309 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact DNA fragmentation involved in apoptotic nuclear change
exact endonucleolytic DNA catabolic process involved in apoptosis
exact DNA catabolism during apoptosis
broad DNA fragmentation
exact DNA catabolic process during apoptosis
broad chromatinolysis

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR015311

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006309:
Relationship To GO:0006309 Child Term Child Term Name
Regulates GO:1902510 regulation of apoptotic DNA fragmentation
Negatively regulates GO:1902511 negative regulation of apoptotic DNA fragmentation
Positively regulates GO:1902512 positive regulation of apoptotic DNA fragmentation

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
Evidence
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006309. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006309 based on the entire annotation set Co-occurrence statistics for GO:0006309 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-05-23 Updated TERM apoptotic DNA fragmentation
2012-05-23 Added SYNONYM DNA fragmentation involved in apoptotic nuclear change
2012-05-15 Deleted RELATION is a GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
2012-05-10 Added SYNONYM chromatinolysis
2010-06-06 Updated TERM DNA fragmentation involved in apoptotic nuclear change
2010-04-09 Added RELATION is a GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
2010-04-09 Deleted RELATION is a GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
2009-04-07 Added RELATION is a GO:0000737 (DNA catabolic process, endonucleolytic)
2009-04-07 Deleted RELATION is a GO:0006308 (DNA catabolic process)
2009-04-07 Updated TERM DNA fragmentation involved in apoptosis
2009-04-07 Added SYNONYM endonucleolytic DNA catabolic process involved in apoptosis
2008-05-13 Added DEFINITION The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
2008-05-12 Deleted DEFINITION The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
2008-04-01 Updated RELATION is a GO:0006308 (DNA catabolic process)
2008-04-01 Updated RELATION is a GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
2008-04-01 Updated RELATION part of GO:0030262 (apoptotic nuclear changes)
2007-08-09 Added SYNONYM DNA fragmentation
2007-08-09 Added SYNONYM DNA catabolism during apoptosis
2007-08-09 Added SYNONYM DNA catabolic process during apoptosis
2007-08-09 Deleted SYNONYM DNA catabolic process during apoptosis
2007-08-09 Deleted SYNONYM DNA catabolism during apoptosis
2007-08-09 Deleted SYNONYM DNA fragmentation
2007-01-15 Added SYNONYM DNA catabolic process during apoptosis
2004-09-23 Updated TERM DNA fragmentation during apoptosis
2004-09-23 Added SYNONYM DNA catabolism during apoptosis
2004-09-23 Added SYNONYM DNA fragmentation
2004-07-25 Updated DEFINITION The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
2002-11-27 Updated DEFINITION Internucleosomal cleavage of chromatin that is characteristic of apoptosis.
2002-02-06 Updated TERM DNA fragmentation
2001-08-06 Added DEFINITION Internucleosomal cleavage of chromatin that is characteristic of apoptosis.
2001-04-03 Updated TERM DNA fragmentation
2001-03-30 Added TERM DNA fragmentation

Term

Timestamp Action Category Detail
2012-05-23 Updated TERM apoptotic DNA fragmentation
2010-06-06 Updated TERM DNA fragmentation involved in apoptotic nuclear change
2009-04-07 Updated TERM DNA fragmentation involved in apoptosis
2004-09-23 Updated TERM DNA fragmentation during apoptosis
2002-02-06 Updated TERM DNA fragmentation
2001-04-03 Updated TERM DNA fragmentation
2001-03-30 Added TERM DNA fragmentation

Definition/synonyms

Timestamp Action Category Detail
2012-05-23 Added SYNONYM DNA fragmentation involved in apoptotic nuclear change
2012-05-10 Added SYNONYM chromatinolysis
2009-04-07 Added SYNONYM endonucleolytic DNA catabolic process involved in apoptosis
2008-05-13 Added DEFINITION The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
2008-05-12 Deleted DEFINITION The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
2007-08-09 Added SYNONYM DNA fragmentation
2007-08-09 Added SYNONYM DNA catabolism during apoptosis
2007-08-09 Added SYNONYM DNA catabolic process during apoptosis
2007-08-09 Deleted SYNONYM DNA catabolic process during apoptosis
2007-08-09 Deleted SYNONYM DNA catabolism during apoptosis
2007-08-09 Deleted SYNONYM DNA fragmentation
2007-01-15 Added SYNONYM DNA catabolic process during apoptosis
2004-09-23 Added SYNONYM DNA catabolism during apoptosis
2004-09-23 Added SYNONYM DNA fragmentation
2004-07-25 Updated DEFINITION The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
2002-11-27 Updated DEFINITION Internucleosomal cleavage of chromatin that is characteristic of apoptosis.
2001-08-06 Added DEFINITION Internucleosomal cleavage of chromatin that is characteristic of apoptosis.

Relationships

Timestamp Action Category Detail
2012-05-15 Deleted RELATION is a GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
2010-04-09 Added RELATION is a GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
2010-04-09 Deleted RELATION is a GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
2009-04-07 Added RELATION is a GO:0000737 (DNA catabolic process, endonucleolytic)
2009-04-07 Deleted RELATION is a GO:0006308 (DNA catabolic process)
2008-04-01 Updated RELATION is a GO:0006308 (DNA catabolic process)
2008-04-01 Updated RELATION is a GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
2008-04-01 Updated RELATION part of GO:0030262 (apoptotic nuclear changes)
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