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GO:0006289 nucleotide-excision repair

Term Information

ID GO:0006289
Name nucleotide-excision repair
Ontology Biological Process
Definition A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
PMID:10197977
Comment Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair.
Secondary IDs GO:0045001
GONUTS GO:0006289 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact NER
related intrastrand cross-link repair
exact pyrimidine-dimer repair, DNA damage excision

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Guidance for interpreting DNA repair investigationsLink

Cross-references

Database ID
InterPro IPR000465
InterPro IPR001044
InterPro IPR001161
InterPro IPR001945
InterPro IPR004583
InterPro IPR004598
InterPro IPR004600
InterPro IPR004601
InterPro IPR004602
InterPro IPR004806
InterPro IPR004807
InterPro IPR009400
InterPro IPR012170
InterPro IPR012904
InterPro IPR015360
InterPro IPR015886
InterPro IPR018325
InterPro IPR027079
InterPro IPR029528

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0006291 pyrimidine-dimer repair, DNA damage excision CONSIDER GO:0006289
GO:0006299 short patch mismatch repair system CONSIDER GO:0006289

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006289:
Relationship To GO:0006289 Child Term Child Term Name
Part of GO:0000715 nucleotide-excision repair, DNA damage recognition
Part of GO:0000717 nucleotide-excision repair, DNA duplex unwinding
Part of GO:0000718 nucleotide-excision repair, DNA damage removal
Is a GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
Is a GO:0006283 transcription-coupled nucleotide-excision repair
Part of GO:0006293 nucleotide-excision repair, preincision complex stabilization
Part of GO:0006294 nucleotide-excision repair, preincision complex assembly
Part of GO:0006297 nucleotide-excision repair, DNA gap filling
Is a GO:0070911 global genome nucleotide-excision repair
Part of GO:0033683 nucleotide-excision repair, DNA incision
Regulates GO:2000819 regulation of nucleotide-excision repair
Is a GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006289. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006289 based on the entire annotation set Co-occurrence statistics for GO:0006289 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-08-10 Deleted SYNONYM interstrand crosslink repair
2009-09-11 Deleted DEFINITION In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2009-09-11 Added DEFINITION A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2008-05-13 Added DEFINITION In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2008-05-12 Deleted DEFINITION In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2008-04-01 Updated RELATION is a GO:0006281 (DNA repair)
2007-08-09 Added SYNONYM NER
2007-08-09 Added SYNONYM interstrand crosslink repair
2007-08-09 Added SYNONYM intrastrand cross-link repair
2007-08-09 Added SYNONYM pyrimidine-dimer repair, DNA damage excision
2007-08-09 Deleted SYNONYM NER
2007-08-09 Deleted SYNONYM interstrand crosslink repair
2007-08-09 Deleted SYNONYM intrastrand cross-link repair
2007-08-09 Deleted SYNONYM pyrimidine-dimer repair, DNA damage excision
2005-10-02 Added SYNONYM NER
2005-08-10 Added SYNONYM pyrimidine-dimer repair, DNA damage excision
2004-05-02 Added SYNONYM interstrand crosslink repair
2004-04-19 Added SYNONYM intrastrand cross-link repair
2004-04-05 Deleted SYNONYM intrastrand cross-link repair
2003-04-29 Updated DEFINITION In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2002-11-27 Added DEFINITION In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide-excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2002-07-26 Added SYNONYM intrastrand cross-link repair
2002-07-26 Added SECONDARY GO:0045001 (intrastrand cross-link repair)
2002-02-06 Updated TERM nucleotide-excision repair
2001-04-03 Updated TERM nucleotide-excision repair
2001-03-30 Added TERM nucleotide-excision repair

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM nucleotide-excision repair
2001-04-03 Updated TERM nucleotide-excision repair
2001-03-30 Added TERM nucleotide-excision repair

Definition/synonyms

Timestamp Action Category Detail
2012-08-10 Deleted SYNONYM interstrand crosslink repair
2009-09-11 Deleted DEFINITION In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2009-09-11 Added DEFINITION A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2008-05-13 Added DEFINITION In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2008-05-12 Deleted DEFINITION In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2007-08-09 Added SYNONYM NER
2007-08-09 Added SYNONYM interstrand crosslink repair
2007-08-09 Added SYNONYM intrastrand cross-link repair
2007-08-09 Added SYNONYM pyrimidine-dimer repair, DNA damage excision
2007-08-09 Deleted SYNONYM NER
2007-08-09 Deleted SYNONYM interstrand crosslink repair
2007-08-09 Deleted SYNONYM intrastrand cross-link repair
2007-08-09 Deleted SYNONYM pyrimidine-dimer repair, DNA damage excision
2005-10-02 Added SYNONYM NER
2005-08-10 Added SYNONYM pyrimidine-dimer repair, DNA damage excision
2004-05-02 Added SYNONYM interstrand crosslink repair
2004-04-19 Added SYNONYM intrastrand cross-link repair
2004-04-05 Deleted SYNONYM intrastrand cross-link repair
2003-04-29 Updated DEFINITION In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2002-11-27 Added DEFINITION In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide-excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
2002-07-26 Added SYNONYM intrastrand cross-link repair

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0006281 (DNA repair)

Other

Timestamp Action Category Detail
2002-07-26 Added SECONDARY GO:0045001 (intrastrand cross-link repair)
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